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CATH Superfamily 3.30.2090.10

Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Efflux pump membrane transporter

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
 113 P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP)
(103 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 90 P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI)
(80 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 84 P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI)
(74 more)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
 15 Q608A0 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS)
(5 more)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
 10 Q9HVI9 (/IDA) Q9I0Y8 (/IDA) Q9I0Y8 (/IDA) Q9I0Y8 (/IDA) Q9I0Y8 (/IDA) Q9I0Y8 (/IDA) Q9I0Y8 (/IDA) Q9I0Y8 (/IDA) Q9I0Y8 (/IDA) Q9I0Y8 (/IDA)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
 6 P52002 (/IGC) P52002 (/IGC) P52002 (/IGC) P52002 (/IGC) P52002 (/IGC) P52002 (/IGC)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Drug transmembrane transport GO:0006855
The process in which a drug is transported across a membrane.
 134 P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP) P24177 (/IMP)
(124 more)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
 84 P31224 (/IMP) P31224 (/IMP) P31224 (/IMP) P31224 (/IMP) P31224 (/IMP) P31224 (/IMP) P31224 (/IMP) P31224 (/IMP) P31224 (/IMP) P31224 (/IMP)
(74 more)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
 29 P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA)
(19 more)
Drug transmembrane transport GO:0006855
The process in which a drug is transported across a membrane.
 14 Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS)
(4 more)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
 14 Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS) Q880Q4 (/ISS)
(4 more)
Drug transport GO:0015893
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 1 Q608A0 (/ISS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
 1 Q9HVI9 (/EXP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 141 P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA)
(131 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 105 P31224 (/HDA) P31224 (/HDA) P31224 (/HDA) P31224 (/HDA) P31224 (/HDA) P31224 (/HDA) P31224 (/HDA) P31224 (/HDA) P31224 (/HDA) P31224 (/HDA)
(95 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 84 P31224 (/IDA) P31224 (/IDA) P31224 (/IDA) P31224 (/IDA) P31224 (/IDA) P31224 (/IDA) P31224 (/IDA) P31224 (/IDA) P31224 (/IDA) P31224 (/IDA)
(74 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 84 P31224 (/RCA) P31224 (/RCA) P31224 (/RCA) P31224 (/RCA) P31224 (/RCA) P31224 (/RCA) P31224 (/RCA) P31224 (/RCA) P31224 (/RCA) P31224 (/RCA)
(74 more)
Efflux pump complex GO:1990281
A protein complex that is capable of efflux transmembrane transporter activity.
 84 P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI) P31224 (/IPI)
(74 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 29 P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA) P24177 (/IDA)
(19 more)
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