The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Metalloproteases ("zincins"), catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: metalloendopeptidase OMA1, mitochondrial isoform X...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
3 D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q96E52 (/IMP)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q9D8H7 (/ISO)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q96E52 (/TAS)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial protein processing GO:0034982
The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.
4 D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) Q9D8H7 (/ISS)
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
3 D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
3 D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS)
Protein quality control for misfolded or incompletely synthesized proteins GO:0006515
The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.
3 D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
3 D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS)
Negative regulation of mitochondrial fusion GO:0010637
Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.
3 D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
3 D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS)
Mitochondrial protein processing GO:0034982
The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.
2 Q96E52 (/IMP) Q9D8H7 (/IMP)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
2 D3ZS74 (/ISS) Q96E52 (/ISS)
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
1 Q96E52 (/IMP)
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
1 Q9D8H7 (/ISO)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 Q96E52 (/IMP)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 Q9D8H7 (/ISO)
Protein quality control for misfolded or incompletely synthesized proteins GO:0006515
The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.
1 Q96E52 (/IMP)
Protein quality control for misfolded or incompletely synthesized proteins GO:0006515
The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.
1 Q9D8H7 (/ISO)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 Q96E52 (/IMP)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 Q9D8H7 (/ISO)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 Q9D8H7 (/IGI)
Negative regulation of mitochondrial fusion GO:0010637
Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.
1 Q96E52 (/IMP)
Negative regulation of mitochondrial fusion GO:0010637
Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.
1 Q9D8H7 (/ISO)
Mitochondrial protein processing GO:0034982
The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.
1 Q9D8H7 (/ISO)
Cristae formation GO:0042407
The assembly of cristae, the inwards folds of the inner mitochondrial membrane.
1 Q9D8H7 (/IGI)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q96E52 (/TAS)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
1 Q96E52 (/IMP)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
1 Q9D8H7 (/ISO)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
1 Q9D8H7 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
3 D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9D8H7 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9D8H7 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q96E52 (/TAS)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
1 Q96E52 (/IDA)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
1 Q9D8H7 (/ISO)
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