The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphorylase Kinase; domain 1
".
FunFam 65: SRSF protein kinase 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
10 | O54781 (/IDA) O70551 (/IDA) O70551 (/IDA) P78362 (/IDA) P78362 (/IDA) Q03563 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) Q9Z0G2 (/IDA) Q9Z0G2 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | O54781 (/IPI) O70551 (/IPI) O70551 (/IPI) P78362 (/IPI) P78362 (/IPI) Q03563 (/IPI) Q96SB4 (/IPI) Q96SB4 (/IPI) Q9UPE1 (/IPI) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
7 | O54781 (/IDA) O70551 (/IDA) O70551 (/IDA) P78362 (/IDA) P78362 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
7 | O54781 (/IDA) O70551 (/IDA) O70551 (/IDA) P78362 (/IDA) P78362 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
4 | P78362 (/HDA) P78362 (/HDA) Q96SB4 (/HDA) Q96SB4 (/HDA) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
3 | O54781 (/ISO) O70551 (/ISO) O70551 (/ISO) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
3 | O54781 (/ISO) O70551 (/ISO) O70551 (/ISO) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
3 | O54781 (/ISO) O70551 (/ISO) O70551 (/ISO) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | Q96SB4 (/TAS) Q96SB4 (/TAS) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
2 | P78362 (/ISS) P78362 (/ISS) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q03563 (/IDA) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
1 | O54781 (/IDA) |
There are 39 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
10 | O54781 (/IDA) O70551 (/IDA) O70551 (/IDA) P78362 (/IDA) P78362 (/IDA) Q03563 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) Q9Z0G2 (/IDA) Q9Z0G2 (/IDA) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
7 | O54781 (/IDA) O70551 (/IDA) O70551 (/IDA) P78362 (/IDA) P78362 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
|
4 | P78362 (/IDA) P78362 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
|
4 | P78362 (/IDA) P78362 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
4 | P78362 (/IC) P78362 (/IC) Q96SB4 (/IC) Q96SB4 (/IC) |
|
Regulation of mRNA splicing, via spliceosome GO:0048024
Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.
|
4 | P78362 (/TAS) P78362 (/TAS) Q96SB4 (/TAS) Q96SB4 (/TAS) |
|
Regulation of mRNA processing GO:0050684
Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
|
4 | O70551 (/IDA) O70551 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
Spliceosomal complex assembly GO:0000245
The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
|
3 | O54781 (/IDA) P78362 (/IDA) P78362 (/IDA) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | O54781 (/ISO) O70551 (/ISO) O70551 (/ISO) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
3 | O54781 (/IDA) P78362 (/IDA) P78362 (/IDA) |
|
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
|
3 | O54781 (/IDA) P78362 (/IDA) P78362 (/IDA) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
3 | O54781 (/ISO) O70551 (/ISO) O70551 (/ISO) |
|
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
|
3 | O54781 (/ISO) O70551 (/ISO) O70551 (/ISO) |
|
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
|
3 | O54781 (/ISO) O70551 (/ISO) O70551 (/ISO) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
2 | P78362 (/ISS) P78362 (/ISS) |
|
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
2 | Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
2 | O70551 (/ISO) O70551 (/ISO) |
|
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
2 | O70551 (/ISS) O70551 (/ISS) |
|
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
2 | Q9Z0G2 (/IMP) Q9Z0G2 (/IMP) |
|
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
|
2 | Q96SB4 (/TAS) Q96SB4 (/TAS) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | P78362 (/ISS) P78362 (/ISS) |
|
Nuclear speck organization GO:0035063
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized.
|
2 | P78362 (/ISS) P78362 (/ISS) |
|
Sperm chromatin condensation GO:0035092
The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication.
|
2 | Q96SB4 (/TAS) Q96SB4 (/TAS) |
|
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
|
2 | P78362 (/ISS) P78362 (/ISS) |
|
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
|
2 | P78362 (/ISS) P78362 (/ISS) |
|
Regulation of mRNA processing GO:0050684
Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
|
2 | O70551 (/ISO) O70551 (/ISO) |
|
Muscle tissue development GO:0060537
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
|
2 | Q9Z0G2 (/IMP) Q9Z0G2 (/IMP) |
|
Muscle tissue development GO:0060537
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
|
2 | B8Y466 (/ISS) Q9UPE1 (/ISS) |
|
Spliceosomal complex assembly GO:0000245
The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
|
1 | O54781 (/ISO) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
1 | O54781 (/IDA) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | O54781 (/ISO) |
|
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
|
1 | O54781 (/ISO) |
|
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
|
1 | Q03563 (/IGI) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | O54781 (/IDA) |
|
Nuclear speck organization GO:0035063
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized.
|
1 | O54781 (/IDA) |
|
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
|
1 | O54781 (/IDA) |
|
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
|
1 | O54781 (/ISS) |
|
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
|
1 | O54781 (/ISS) |
|
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
|
1 | O54781 (/IDA) |
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | A0A024R704 (/IDA) A0A024R704 (/IDA) O54781 (/IDA) P78362 (/IDA) P78362 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | A0A024R704 (/IDA) A0A024R704 (/IDA) P78362 (/IDA) P78362 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | O54781 (/IDA) P78362 (/IDA) P78362 (/IDA) Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | A0A024R704 (/IDA) A0A024R704 (/IDA) P78362 (/IDA) P78362 (/IDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
4 | A0A024R704 (/IDA) A0A024R704 (/IDA) P78362 (/IDA) P78362 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O54781 (/ISO) O70551 (/ISO) O70551 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | O54781 (/ISO) O70551 (/ISO) O70551 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | O54781 (/ISO) O70551 (/ISO) O70551 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | O70551 (/ISS) O70551 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q96SB4 (/TAS) Q96SB4 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O70551 (/ISS) O70551 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q96SB4 (/IDA) Q96SB4 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | O70551 (/ISO) O70551 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | O54781 (/ISO) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | O54781 (/ISO) |
