The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphorylase Kinase; domain 1
".
FunFam 379: eIF-2-alpha kinase GCN2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
|
5 | O13889 (/IDA) P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) Q9UTE5 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | O13889 (/IPI) P15442 (/IPI) P15442 (/IPI) P15442 (/IPI) Q9UTE5 (/IPI) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
4 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) Q9HGN1 (/IDA) |
|
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
|
4 | A0A1D8PQT9 (/IMP) O13889 (/IMP) Q9HGN1 (/IMP) Q9UTE5 (/IMP) |
|
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
3 | O13889 (/ISM) Q9HGN1 (/ISM) Q9UTE5 (/ISM) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
3 | P15442 (/IPI) P15442 (/IPI) P15442 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Ribosomal large subunit binding GO:0043023
Interacting selectively and non-covalently with any part of the larger ribosomal subunit.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
|
1 | Q4WU06 (/ISA) |
|
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
|
1 | A0A1D8PQT9 (/ISS) |
There are 40 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
|
5 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) Q4WU06 (/IMP) Q9HGN1 (/IMP) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
4 | A0A1D8PQT9 (/IMP) P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
DNA damage checkpoint GO:0000077
A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Chronological cell aging GO:0001300
The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Regulation of eIF2 alpha phosphorylation by amino acid starvation GO:0060733
Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Regulation of eIF2 alpha phosphorylation by amino acid starvation GO:0060733
Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Cellular response to histidine GO:0071232
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Positive regulation of translational initiation in response to starvation GO:0071264
Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Positive regulation of translational initiation in response to starvation GO:0071264
Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Cellular response to benomyl GO:0072755
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Negative regulation of protein kinase activity by protein phosphorylation GO:0100002
Any protein phosphorylation process that negatively_regulates protein kinase activity
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Positive regulation of cellular response to amino acid starvation GO:1903833
Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Positive regulation of cellular response to amino acid starvation GO:1903833
Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.
|
3 | P15442 (/IGI) P15442 (/IGI) P15442 (/IGI) |
|
Positive regulation of cellular response to amino acid starvation GO:1903833
Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Negative regulation of TORC1 signaling GO:1904262
Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Cellular stress response to acidic pH GO:1990451
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.
|
3 | P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) |
|
Negative regulation of cytoplasmic translational initiation in response to stress GO:1990625
Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.
|
3 | O13889 (/IMP) Q9HGN1 (/IMP) Q9UTE5 (/IMP) |
|
G1 cell cycle arrest in response to nitrogen starvation GO:0071849
The process in which the cell cycle is halted during G1 phase, as a result of deprivation of nitrogen.
|
2 | Q9HGN1 (/IMP) Q9UTE5 (/IMP) |
|
Cytoplasmic translational initiation GO:0002183
The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
1 | Q9UTE5 (/NAS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | A0A1D8PQT9 (/ISS) |
|
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
|
1 | A0A1D8PQT9 (/IMP) |
|
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
|
1 | A0A1D8PQT9 (/IMP) |
|
Mitotic G1 DNA damage checkpoint GO:0031571
A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage.
|
1 | Q9HGN1 (/IMP) |
|
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
|
1 | Q9HGN1 (/ISS) |
|
Filamentous growth of a population of unicellular organisms in response to chemical stimulus GO:0036171
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus.
|
1 | A0A1D8PQT9 (/IMP) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | Q9HGN1 (/ISS) |
|
Signal transduction involved in mitotic G1 DNA damage checkpoint GO:0072431
A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint.
|
1 | Q9HGN1 (/IMP) |
|
Cellular response to benomyl GO:0072755
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus.
|
1 | Q9HGN1 (/ISS) |
|
Cellular response to N-acetyl-D-glucosamine GO:0097316
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus.
|
1 | A0A1D8PQT9 (/IMP) |
|
Positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus GO:1900439
Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus.
|
1 | A0A1D8PQT9 (/IMP) |
|
Regulation of translation involved in cellular response to UV GO:1904803
Any regulation of translation that is involved in cellular response to UV.
|
1 | Q9HGN1 (/IMP) |
|
Cellular stress response to acidic pH GO:1990451
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.
|
1 | Q9HGN1 (/ISS) |
|
Negative regulation of cytoplasmic translational initiation in response to stress GO:1990625
Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.
|
1 | Q9HGN1 (/IDA) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Large ribosomal subunit GO:0015934
The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Small ribosomal subunit GO:0015935
The smaller of the two subunits of a ribosome.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
|
3 | P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O13889 (/HDA) Q9UTE5 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9HGN1 (/ISO) |