The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 218: Tyrosine-protein kinase RYK

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P34925 (/IPI) Q01887 (/IPI)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
2 A2RRV7 (/IDA) E7FAI5 (/IDA)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
2 Q01887 (/IPI) Q6GLP3 (/IPI)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
2 Q01887 (/TAS) Q4V865 (/TAS)
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
2 Q01887 (/TAS) Q6BC88 (/TAS)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
1 P34925 (/IDA)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
1 Q01887 (/ISO)
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
1 Q01887 (/IPI)
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
1 P34925 (/ISS)
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
1 P34925 (/NAS)
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
1 Q4V865 (/TAS)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
1 P34925 (/ISS)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
1 P34925 (/NAS)
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 Q01887 (/IPI)
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 P34925 (/ISS)
Coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway GO:1904929
Any coreceptor activity that is involved in Wnt signaling pathway, planar cell polarity pathway.
1 P34925 (/TAS)

There are 49 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Wnt signaling pathway, calcium modulating pathway GO:0007223
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
2 A2RRV7 (/IMP) E7FAI5 (/IMP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
2 Q01887 (/IGI) Q6BC88 (/IGI)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 P34925 (/ISS) Q6BC88 (/ISS)
Corpus callosum development GO:0022038
The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.
2 P34925 (/ISS) Q6BC88 (/ISS)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
2 A2RRV7 (/IMP) E7FAI5 (/IMP)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
2 Q01887 (/ISS) Q6BC88 (/ISS)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
2 A2RRV7 (/IMP) E7FAI5 (/IMP)
Convergent extension GO:0060026
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.
2 A2RRV7 (/IGI) E7FAI5 (/IGI)
Convergent extension involved in axis elongation GO:0060028
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.
2 A2RRV7 (/IGI) E7FAI5 (/IGI)
Convergent extension involved in axis elongation GO:0060028
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.
2 A2RRV7 (/IMP) E7FAI5 (/IMP)
Dorsal convergence GO:0060030
The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.
2 A2RRV7 (/IMP) E7FAI5 (/IMP)
Planar cell polarity pathway involved in axon guidance GO:1904938
Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance.
2 P34925 (/ISS) Q6BC88 (/ISS)
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1904953
Any Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation.
2 P34925 (/ISS) Q01887 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P34925 (/TAS)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
1 P34925 (/ISS)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
1 P34925 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q01887 (/IDA)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q01887 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 P34925 (/NAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q01887 (/TAS)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
1 P34925 (/NAS)
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
1 Q01887 (/IDA)
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
1 Q01887 (/IGI)
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
1 P34925 (/TAS)
Neurogenesis GO:0022008
Generation of cells within the nervous system.
1 P34925 (/NAS)
Corpus callosum development GO:0022038
The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.
1 Q01887 (/IMP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q01887 (/IDA)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 P34925 (/ISS)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q01887 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P34925 (/ISS)
Cell proliferation in midbrain GO:0033278
The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.
1 Q6BC88 (/IMP)
Cell proliferation in midbrain GO:0033278
The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.
1 P34925 (/ISS)
Non-canonical Wnt signaling pathway GO:0035567
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.
1 P34925 (/NAS)
Chemorepulsion of dopaminergic neuron axon GO:0036518
The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
1 Q01887 (/IGI)
Chemorepulsion of dopaminergic neuron axon GO:0036518
The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
1 P34925 (/ISS)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 P34925 (/IDA)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 Q01887 (/ISO)
Skeletal system morphogenesis GO:0048705
The process in which the anatomical structures of the skeleton are generated and organized.
1 Q01887 (/IMP)
Negative regulation of axon extension involved in axon guidance GO:0048843
Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance.
1 Q01887 (/IGI)
Negative chemotaxis GO:0050919
The directed movement of a motile cell or organism towards a lower concentration of a chemical.
1 Q01887 (/IGI)
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
1 P34925 (/NAS)
Chemorepulsion of axon GO:0061643
The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
1 Q01887 (/TAS)
Commissural neuron axon guidance GO:0071679
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
1 Q01887 (/IMP)
Commissural neuron axon guidance GO:0071679
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
1 P34925 (/ISS)
Planar cell polarity pathway involved in axon guidance GO:1904938
Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance.
1 Q01887 (/IGI)
Midbrain dopaminergic neuron differentiation GO:1904948
The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron.
1 Q01887 (/IMP)
Midbrain dopaminergic neuron differentiation GO:1904948
The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron.
1 P34925 (/ISS)
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1904953
Any Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation.
1 Q6BC88 (/IGI)
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1904953
Any Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation.
1 P34925 (/TAS)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 A2RRV7 (/IDA) E7FAI5 (/IDA) Q01887 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P34925 (/ISS) Q6BC88 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P34925 (/ISS) Q6BC88 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P34925 (/ISS) Q6BC88 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q01887 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P34925 (/NAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q01887 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P34925 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P34925 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P34925 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q01887 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P34925 (/NAS)