The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Tyrosine-protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 104 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
35 P00523 (/IPI) P05480 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI)
(25 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
29 P05480 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(19 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
26 P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI)
(16 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
24 P00523 (/EXP) P05480 (/EXP) P06241 (/EXP) P06241 (/EXP) P06241 (/EXP) P06241 (/EXP) P06241 (/EXP) P06241 (/EXP) P06241 (/EXP) P06241 (/EXP)
(14 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
24 P05480 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP)
(14 more)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
21 P05480 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI)
(11 more)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
20 P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS)
(10 more)
Growth factor receptor binding GO:0070851
Interacting selectively and non-covalently with a growth factor receptor.
20 P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI)
(10 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
18 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(8 more)
Type 5 metabotropic glutamate receptor binding GO:0031802
Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
17 P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI)
(7 more)
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
17 P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS)
(7 more)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Tau-protein kinase activity GO:0050321
Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.
17 P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS)
(7 more)
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
17 P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI) P06241 (/IPI)
(7 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
12 A1A5H8 (/IDA) F1LM93 (/IDA) P09769 (/IDA) P12931 (/IDA) P12931 (/IDA) P12931 (/IDA) P39688 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
(2 more)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
9 P05480 (/IDA) P12931 (/IDA) P12931 (/IDA) P12931 (/IDA) P39688 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q6EWH2 (/IDA)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
7 P12931 (/IPI) P12931 (/IPI) P12931 (/IPI) Q62844 (/IPI) Q62844 (/IPI) Q62844 (/IPI) Q9WUD9 (/IPI)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
7 P07947 (/IPI) P07947 (/IPI) P12931 (/IPI) P12931 (/IPI) P12931 (/IPI) P39688 (/IPI) Q9WUD9 (/IPI)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
6 P07947 (/TAS) P07947 (/TAS) P09769 (/TAS) P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
5 P05480 (/ISO) P14234 (/ISO) P39688 (/ISO) Q04736 (/ISO) Q04736 (/ISO)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
4 P12931 (/IPI) P12931 (/IPI) P12931 (/IPI) Q9WUD9 (/IPI)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
4 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS) Q9WUD9 (/TAS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
4 P05480 (/ISO) P39688 (/ISO) Q04736 (/ISO) Q04736 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
4 Q62844 (/IPI) Q62844 (/IPI) Q62844 (/IPI) Q9WUD9 (/IPI)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
4 P05480 (/IPI) P12931 (/IPI) P12931 (/IPI) P12931 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
3 P07947 (/IPI) P07947 (/IPI) P09769 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
3 P14234 (/ISO) Q04736 (/ISO) Q04736 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
3 P12931 (/NAS) P12931 (/NAS) P12931 (/NAS)
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
3 P12931 (/IPI) P12931 (/IPI) P12931 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
3 P12931 (/IPI) P12931 (/IPI) P12931 (/IPI)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
3 P12931 (/IDA) P12931 (/IDA) P12931 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
3 P00523 (/ISS) P05480 (/ISS) Q9WUD9 (/ISS)
Type 5 metabotropic glutamate receptor binding GO:0031802
Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor.
3 Q62844 (/IPI) Q62844 (/IPI) Q62844 (/IPI)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
3 P12931 (/IPI) P12931 (/IPI) P12931 (/IPI)
T cell receptor binding GO:0042608
Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.
3 Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
CD4 receptor binding GO:0042609
Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.
3 Q62844 (/IPI) Q62844 (/IPI) Q62844 (/IPI)
CD8 receptor binding GO:0042610
Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.
3 Q62844 (/IPI) Q62844 (/IPI) Q62844 (/IPI)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
3 Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
3 P05480 (/ISO) Q04736 (/ISO) Q04736 (/ISO)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
3 P12931 (/HDA) P12931 (/HDA) P12931 (/HDA)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
3 P12931 (/IPI) P12931 (/IPI) P12931 (/IPI)
Peptide hormone receptor binding GO:0051428
Interacting selectively and non-covalently with a receptor for peptide hormones.
3 Q62844 (/IPI) Q62844 (/IPI) Q62844 (/IPI)
BMP receptor binding GO:0070700
Interacting selectively and non-covalently with a BMP receptor.
3 P12931 (/IPI) P12931 (/IPI) P12931 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 P05480 (/ISO) P39688 (/ISO)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
2 P09769 (/IDA) P14234 (/IDA)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 P05480 (/ISO) P39688 (/ISO)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
2 Q04736 (/ISO) Q04736 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P14234 (/IPI) Q9WUD9 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Immunoglobulin receptor binding GO:0034987
Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 P05480 (/ISO) P39688 (/ISO)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
2 P05480 (/ISO) P39688 (/ISO)
Growth factor receptor binding GO:0070851
Interacting selectively and non-covalently with a growth factor receptor.
2 P05480 (/ISO) P39688 (/ISO)
Connexin binding GO:0071253
Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions.
2 P00523 (/IPI) P05480 (/IPI)
G protein-coupled receptor binding GO:0001664
Interacting selectively and non-covalently with a G protein-coupled receptor.
1 P39688 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
1 P14234 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P05480 (/IMP)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 Q05876 (/ISS)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
1 P14234 (/ISO)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
1 Q9WUD9 (/IPI)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
1 P05480 (/ISO)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 F1LM93 (/IPI)
Insulin receptor binding GO:0005158
Interacting selectively and non-covalently with the insulin receptor.
1 Q9WUD9 (/IPI)
Insulin receptor binding GO:0005158
Interacting selectively and non-covalently with the insulin receptor.
1 P05480 (/ISO)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P05480 (/ISO)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P05480 (/ISO)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
1 P39688 (/IDA)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
1 Q05876 (/ISS)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 P05480 (/IMP)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P05480 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P14234 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P05480 (/ISO)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 P00523 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P05480 (/IPI)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 P05480 (/ISO)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
1 Q9WUD9 (/IPI)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
1 P05480 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 Q9WUD9 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P05480 (/ISO)
Type 5 metabotropic glutamate receptor binding GO:0031802
Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor.
1 P39688 (/ISO)
Immunoglobulin receptor binding GO:0034987
Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule.
1 P14234 (/IDA)
Fc-gamma receptor I complex binding GO:0034988
Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.
1 P09769 (/IDA)
Fc-gamma receptor I complex binding GO:0034988
Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.
1 P14234 (/ISO)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
1 P05480 (/ISO)
T cell receptor binding GO:0042608
Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.
1 P39688 (/ISO)
CD4 receptor binding GO:0042609
Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.
1 P39688 (/ISO)
CD8 receptor binding GO:0042610
Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.
1 P39688 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P39688 (/ISO)
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
1 P39688 (/IDA)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
1 P39688 (/ISO)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
1 P39688 (/IPI)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 Q9WUD9 (/IPI)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 P05480 (/ISO)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
1 P05480 (/ISO)
Peptide hormone receptor binding GO:0051428
Interacting selectively and non-covalently with a receptor for peptide hormones.
1 P39688 (/ISO)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 P05480 (/ISO)
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
1 P39688 (/ISO)

There are 314 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
24 P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP)
(14 more)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
23 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(13 more)
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
22 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(12 more)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
22 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(12 more)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
22 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(12 more)
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
20 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(10 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
20 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(10 more)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
20 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(10 more)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
20 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(10 more)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
20 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(10 more)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
20 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(10 more)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
20 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(10 more)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
19 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(9 more)
Heart process GO:0003015
A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
18 P06241 (/IGI) P06241 (/IGI) P06241 (/IGI) P06241 (/IGI) P06241 (/IGI) P06241 (/IGI) P06241 (/IGI) P06241 (/IGI) P06241 (/IGI) P06241 (/IGI)
(8 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
18 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(8 more)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Response to singlet oxygen GO:0000304
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
17 P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS)
(7 more)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
17 P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS) P06241 (/NAS)
(7 more)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Negative regulation of hydrogen peroxide biosynthetic process GO:0010730
Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Regulation of defense response to virus by virus GO:0050690
Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
17 P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA)
(7 more)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Dendritic spine maintenance GO:0097062
The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Regulation of glutamate receptor signaling pathway GO:1900449
Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Negative regulation of dendritic spine maintenance GO:1902951
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic spine maintenance.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Negative regulation of oxidative stress-induced cell death GO:1903202
Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997
Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Response to amyloid-beta GO:1904645
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
17 P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP)
(7 more)
Cellular response to L-glutamate GO:1905232
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Cellular response to glycine GO:1905430
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Positive regulation of protein localization to membrane GO:1905477
Any process that activates or increases the frequency, rate or extent of protein localization to membrane.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Regulation of calcium ion import across plasma membrane GO:1905664
Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Positive regulation of cysteine-type endopeptidase activity GO:2001056
Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
12 A1A5H8 (/IDA) F1LM93 (/IDA) P09769 (/IDA) P12931 (/IDA) P12931 (/IDA) P12931 (/IDA) P39688 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
(2 more)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
10 E2RSH8 (/IMP) E2RSH8 (/IMP) E2RSH8 (/IMP) E2RSH8 (/IMP) E2RSH8 (/IMP) E2RSH8 (/IMP) E2RSH8 (/IMP) P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
10 P05480 (/IDA) P09769 (/IDA) P12931 (/IDA) P12931 (/IDA) P12931 (/IDA) P14234 (/IDA) P39688 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
10 E2RSH8 (/IC) E2RSH8 (/IC) E2RSH8 (/IC) E2RSH8 (/IC) E2RSH8 (/IC) E2RSH8 (/IC) E2RSH8 (/IC) P12931 (/IC) P12931 (/IC) P12931 (/IC)
Positive regulation of lamellipodium morphogenesis GO:2000394
Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis.
10 E2RSH8 (/IMP) E2RSH8 (/IMP) E2RSH8 (/IMP) E2RSH8 (/IMP) E2RSH8 (/IMP) E2RSH8 (/IMP) E2RSH8 (/IMP) P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
5 P09769 (/IMP) P12931 (/IMP) P12931 (/IMP) P12931 (/IMP) P14234 (/IMP)
Regulation of vascular permeability GO:0043114
Any process that modulates the extent to which blood vessels can be pervaded by fluid.
5 P07947 (/TAS) P07947 (/TAS) P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
5 P05480 (/ISO) P14234 (/ISO) P39688 (/ISO) Q04736 (/ISO) Q04736 (/ISO)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
4 P09769 (/IMP) Q62844 (/IMP) Q62844 (/IMP) Q62844 (/IMP)
Cellular response to platelet-derived growth factor stimulus GO:0036120
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
4 P05480 (/IDA) P39688 (/IDA) Q04736 (/IDA) Q04736 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
4 Q62844 (/IEP) Q62844 (/IEP) Q62844 (/IEP) Q9WUD9 (/IEP)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
4 P12931 (/ISS) P12931 (/ISS) P12931 (/ISS) Q9WUD9 (/ISS)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
4 P05480 (/IGI) P39688 (/IGI) Q04736 (/IGI) Q04736 (/IGI)
Response to singlet oxygen GO:0000304
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst.
3 Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Signal complex assembly GO:0007172
The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell.
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Regulation of epithelial cell migration GO:0010632
Any process that modulates the frequency, rate or extent of epithelial cell migration.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Negative regulation of hydrogen peroxide biosynthetic process GO:0010730
Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
3 Q62844 (/IMP) Q62844 (/IMP) Q62844 (/IMP)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
3 P05480 (/ISO) P14234 (/ISO) P39688 (/ISO)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
3 P12931 (/NAS) P12931 (/NAS) P12931 (/NAS)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Negative regulation of protein homooligomerization GO:0032463
Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Positive regulation of integrin activation GO:0033625
Any process that activates or increases the frequency, rate, or extent of integrin activation.
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Ionotropic glutamate receptor signaling pathway GO:0035235
A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
3 Q62844 (/TAS) Q62844 (/TAS) Q62844 (/TAS)
Positive regulation of dephosphorylation GO:0035306
Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule.
3 P12931 (/IDA) P12931 (/IDA) P12931 (/IDA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
3 P12931 (/IDA) P12931 (/IDA) P12931 (/IDA)
Entry of bacterium into host cell GO:0035635
The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
ERBB2 signaling pathway GO:0038128
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
3 Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
3 Q62844 (/IMP) Q62844 (/IMP) Q62844 (/IMP)
Regulation of bone resorption GO:0045124
Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).
3 P12931 (/TAS) P12931 (/TAS) P12931 (/TAS)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
3 A1A5H8 (/IGI) F1RDG9 (/IGI) Q6EWH2 (/IGI)
Macrophage chemotaxis GO:0048246
The movement of a macrophage in response to an external stimulus.
3 A5WWJ6 (/IMP) Q66HZ1 (/IMP) Q8AWF1 (/IMP)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Progesterone receptor signaling pathway GO:0050847
Any series of molecular signals generated as a consequence of a progesterone binding to its receptor.
3 P12931 (/ISS) P12931 (/ISS) P12931 (/ISS)
Positive regulation of small GTPase mediated signal transduction GO:0051057
Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Negative regulation of focal adhesion assembly GO:0051895
Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
3 P12931 (/ISS) P12931 (/ISS) P12931 (/ISS)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Negative regulation of mitochondrial depolarization GO:0051902
Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Negative regulation of telomerase activity GO:0051974
Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
3 A1A5H8 (/IGI) F1RDG9 (/IGI) Q6EWH2 (/IGI)
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
3 Q62844 (/IEP) Q62844 (/IEP) Q62844 (/IEP)
Cellular response to peptide hormone stimulus GO:0071375
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
3 Q62844 (/IEP) Q62844 (/IEP) Q62844 (/IEP)
Cellular response to peptide hormone stimulus GO:0071375
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
3 P12931 (/ISS) P12931 (/ISS) P12931 (/ISS)
Cellular response to progesterone stimulus GO:0071393
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
3 P12931 (/ISS) P12931 (/ISS) P12931 (/ISS)
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
3 P12931 (/IDA) P12931 (/IDA) P12931 (/IDA)
Angiotensin-activated signaling pathway involved in heart process GO:0086098
An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
3 P12931 (/ISS) P12931 (/ISS) P12931 (/ISS)
Negative regulation of oxidative stress-induced cell death GO:1903202
Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death.
3 Q62844 (/IMP) Q62844 (/IMP) Q62844 (/IMP)
Positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997
Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.
3 P12931 (/NAS) P12931 (/NAS) P12931 (/NAS)
Cellular response to L-glutamate GO:1905232
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus.
3 Q62844 (/IMP) Q62844 (/IMP) Q62844 (/IMP)
Cellular response to glycine GO:1905430
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus.
3 Q62844 (/IMP) Q62844 (/IMP) Q62844 (/IMP)
Regulation of early endosome to late endosome transport GO:2000641
Any process that modulates the frequency, rate or extent of early endosome to late endosome transport.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Negative regulation of anoikis GO:2000811
Any process that stops, prevents or reduces the frequency, rate or extent of anoikis.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Positive regulation of cysteine-type endopeptidase activity GO:2001056
Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.
3 Q62844 (/IMP) Q62844 (/IMP) Q62844 (/IMP)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
3 Q62844 (/IMP) Q62844 (/IMP) Q62844 (/IMP)
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Regulation of caveolin-mediated endocytosis GO:2001286
Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis.
3 P12931 (/IMP) P12931 (/IMP) P12931 (/IMP)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
2 P07947 (/TAS) P07947 (/TAS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P05480 (/ISO) P14234 (/ISO)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Regulation of glucose transmembrane transport GO:0010827
Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q04736 (/IDA) Q04736 (/IDA)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
2 P14234 (/ISO) P39688 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
2 P05480 (/IGI) P39688 (/IGI)
Adherens junction maintenance GO:0034334
The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
2 A1A5H8 (/IGI) Q6EWH2 (/IGI)
Positive regulation of mast cell degranulation GO:0043306
Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Positive regulation of phosphatidylinositol 3-kinase activity GO:0043552
Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
2 P09769 (/IMP) Q9WUD9 (/IMP)
Positive regulation of phosphatidylinositol 3-kinase activity GO:0043552
Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
2 P05480 (/ISO) P14234 (/ISO)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q04736 (/IGI) Q04736 (/IGI)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 Q04736 (/IDA) Q04736 (/IDA)
Regulation of phagocytosis GO:0050764
Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P05480 (/IMP) Q9WUD9 (/IMP)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
2 Q04736 (/IDA) Q04736 (/IDA)
Response to singlet oxygen GO:0000304
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst.
1 P39688 (/ISO)
Primary ovarian follicle growth GO:0001545
Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle).
1 Q9WUD9 (/IMP)
Primary ovarian follicle growth GO:0001545
Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle).
1 P05480 (/ISO)
Gastrulation with mouth forming second GO:0001702
A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
1 Q6EWH2 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 P39688 (/IGI)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 P39688 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q05876 (/ISS)
Response to yeast GO:0001878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.
1 Q1JPZ3 (/IDA)
Immune response-regulating cell surface receptor signaling pathway GO:0002768
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.
1 P09769 (/TAS)
Heart process GO:0003015
A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P39688 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P05480 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P39688 (/IMP)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P39688 (/IDA)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q9WUD9 (/IEP)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P05480 (/ISO)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q9WUD9 (/IDA)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 P05480 (/ISO)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 P39688 (/IDA)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 P14234 (/IMP)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 Q9WUD9 (/IEP)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q9WUD9 (/IEP)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 P09769 (/TAS)
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
1 Q9WUD9 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9WUD9 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P05480 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P39688 (/IMP)
Regulation of epithelial cell migration GO:0010632
Any process that modulates the frequency, rate or extent of epithelial cell migration.
1 P05480 (/ISO)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
1 P05480 (/ISO)
Positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641
Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
1 Q9WUD9 (/IEP)
Negative regulation of hydrogen peroxide biosynthetic process GO:0010730
Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
1 P39688 (/ISO)
Positive regulation of glucose metabolic process GO:0010907
Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
1 Q9WUD9 (/IMP)
Positive regulation of glucose metabolic process GO:0010907
Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
1 P05480 (/ISO)
Positive regulation of protein processing GO:0010954
Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.
1 P05480 (/IGI)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P39688 (/IGI)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
1 Q9WUD9 (/IMP)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
1 P05480 (/ISO)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
1 P05480 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 P05480 (/IMP)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 Q9WUD9 (/IMP)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 P05480 (/ISO)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
1 P05480 (/ISO)
Bone mineralization GO:0030282
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
1 P14234 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P14234 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 P39688 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 Q05876 (/ISS)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
1 F1RDG9 (/IMP)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 P39688 (/IDA)
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
1 P05480 (/IMP)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 Q9WUD9 (/IEP)
Positive regulation of protein autophosphorylation GO:0031954
Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.
1 Q9WUD9 (/IMP)
Positive regulation of protein autophosphorylation GO:0031954
Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.
1 P05480 (/ISO)
Activation of protein kinase B activity GO:0032148
Any process that initiates the activity of the inactive enzyme protein kinase B.
1 Q9WUD9 (/IMP)
Activation of protein kinase B activity GO:0032148
Any process that initiates the activity of the inactive enzyme protein kinase B.
1 P05480 (/ISO)
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
1 P05480 (/ISO)
Negative regulation of protein homooligomerization GO:0032463
Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization.
1 P05480 (/ISO)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 Q9WUD9 (/IEP)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 P14234 (/TAS)
Regulation of intracellular estrogen receptor signaling pathway GO:0033146
Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
1 P05480 (/IMP)
Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
1 Q9WUD9 (/IDA)
Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
1 P05480 (/ISO)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 P05480 (/IDA)
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 P05480 (/IDA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P05480 (/IGI)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P05480 (/ISO)
Osteoclast development GO:0036035
The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 P05480 (/IGI)
Negative regulation of protein catabolic process GO:0042177
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 P39688 (/IMP)
Odontogenesis GO:0042476
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
1 P05480 (/IMP)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 P39688 (/IMP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q9WUD9 (/IEP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P39688 (/ISO)
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
1 Q6EWH2 (/IMP)
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
1 P39688 (/TAS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q9WUD9 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P05480 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P05480 (/ISO)
Regulation of vascular permeability GO:0043114
Any process that modulates the extent to which blood vessels can be pervaded by fluid.
1 Q1JPZ3 (/IMP)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 P39688 (/IGI)
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
1 P05480 (/ISO)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
1 P05480 (/ISO)
Positive regulation of mast cell degranulation GO:0043306
Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
1 P14234 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P09769 (/TAS)
Regulation of protein binding GO:0043393
Any process that modulates the frequency, rate or extent of protein binding.
1 P05480 (/IDA)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
1 Q9WUD9 (/IMP)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
1 P05480 (/ISO)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 P39688 (/ISO)
Transcytosis GO:0045056
The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.
1 Q9WUD9 (/IDA)
Transcytosis GO:0045056
The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.
1 P05480 (/ISO)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 P14234 (/IMP)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
1 P05480 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P39688 (/IGI)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737
Any process that activates or increases the frequency, rate or extent of CDK activity.
1 Q9WUD9 (/IMP)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737
Any process that activates or increases the frequency, rate or extent of CDK activity.
1 P05480 (/ISO)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 Q9WUD9 (/IDA)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 P05480 (/ISO)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
1 P14234 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9WUD9 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P05480 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9WUD9 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P05480 (/ISO)
Positive regulation of insulin receptor signaling pathway GO:0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
1 Q9WUD9 (/IDA)
Positive regulation of insulin receptor signaling pathway GO:0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
1 P05480 (/ISO)
Neurotrophin TRK receptor signaling pathway GO:0048011
A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9WUD9 (/IDA)
Neurotrophin TRK receptor signaling pathway GO:0048011
A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P05480 (/ISO)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
1 P05480 (/IMP)
Skeletal system morphogenesis GO:0048705
The process in which the anatomical structures of the skeleton are generated and organized.
1 P14234 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
1 P39688 (/IMP)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
1 P14234 (/IDA)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
1 Q9WUD9 (/IMP)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
1 P05480 (/ISO)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 P39688 (/IGI)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 P05480 (/IGI)
Regulation of phagocytosis GO:0050764
Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
1 P14234 (/IMP)
Activated T cell proliferation GO:0050798
The expansion of a T cell population following activation by an antigenic stimulus.
1 P39688 (/IMP)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P39688 (/IDA)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P39688 (/IMP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 P14234 (/IGI)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 P14234 (/IMP)
Progesterone receptor signaling pathway GO:0050847
Any series of molecular signals generated as a consequence of a progesterone binding to its receptor.
1 Q9WUD9 (/IMP)
Progesterone receptor signaling pathway GO:0050847
Any series of molecular signals generated as a consequence of a progesterone binding to its receptor.
1 P05480 (/ISO)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
1 P39688 (/ISO)
Detection of mechanical stimulus involved in sensory perception of pain GO:0050966
The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal.
1 P39688 (/IMP)
Positive regulation of small GTPase mediated signal transduction GO:0051057
Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.
1 P05480 (/ISO)
Positive regulation of protein transport GO:0051222
Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9WUD9 (/IMP)
Positive regulation of protein transport GO:0051222
Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P05480 (/ISO)
Response to mineralocorticoid GO:0051385
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance.
1 Q9WUD9 (/IEP)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
1 Q6EWH2 (/IMP)
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
1 Q9WUD9 (/IEP)
Negative regulation of focal adhesion assembly GO:0051895
Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
1 Q9WUD9 (/IMP)
Negative regulation of focal adhesion assembly GO:0051895
Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
1 P05480 (/ISO)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 P05480 (/ISO)
Negative regulation of mitochondrial depolarization GO:0051902
Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.
1 P05480 (/ISO)
Negative regulation of telomerase activity GO:0051974
Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
1 P05480 (/ISO)
Uterus development GO:0060065
The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure.
1 P05480 (/IMP)
Branching involved in mammary gland duct morphogenesis GO:0060444
The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
1 P05480 (/IMP)
Regulation of cell projection assembly GO:0060491
Any process that modulates the rate, frequency, or extent of cell projection assembly.
1 P05480 (/IGI)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P05480 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P05480 (/ISO)
Response to fatty acid GO:0070542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
1 Q9WUD9 (/IEP)
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 P05480 (/ISO)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q9WUD9 (/IEP)
Cellular response to peptide hormone stimulus GO:0071375
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P05480 (/IGI)
Cellular response to progesterone stimulus GO:0071393
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
1 Q9WUD9 (/IMP)
Cellular response to progesterone stimulus GO:0071393
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
1 P05480 (/ISO)
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
1 Q9WUD9 (/IEP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q9WUD9 (/IEP)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
1 P05480 (/IMP)
Positive regulation of podosome assembly GO:0071803
Any process that activates or increases the rate or extent of podosome assembly.
1 P05480 (/IDA)
Positive regulation of podosome assembly GO:0071803
Any process that activates or increases the rate or extent of podosome assembly.
1 P05480 (/IGI)
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
1 P05480 (/ISO)
Angiotensin-activated signaling pathway involved in heart process GO:0086098
An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
1 P05480 (/IGI)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 P05480 (/IGI)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
1 P39688 (/IGI)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 Q9WUD9 (/IEP)
Regulation of postsynaptic neurotransmitter receptor activity GO:0098962
Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
1 Q9WUD9 (/EXP)
Regulation of postsynaptic neurotransmitter receptor activity GO:0098962
Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
1 Q9WUD9 (/IDA)
Regulation of postsynaptic neurotransmitter receptor activity GO:0098962
Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
1 P05480 (/ISO)
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
1 P39688 (/IDA)
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
1 P05480 (/IGI)
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
1 P39688 (/IMP)
Regulation of glutamate receptor signaling pathway GO:1900449
Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway.
1 P39688 (/IGI)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 P39688 (/IGI)
Positive regulation of intracellular signal transduction GO:1902533
Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
1 Q9WUD9 (/IMP)
Positive regulation of intracellular signal transduction GO:1902533
Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
1 P05480 (/ISO)
Negative regulation of dendritic spine maintenance GO:1902951
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic spine maintenance.
1 P39688 (/IGI)
Negative regulation of oxidative stress-induced cell death GO:1903202
Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death.
1 P39688 (/ISO)
Response to amyloid-beta GO:1904645
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
1 P39688 (/IGI)
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
1 P39688 (/ISO)
Cellular response to L-glutamate GO:1905232
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus.
1 P39688 (/ISO)
Cellular response to glycine GO:1905430
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus.
1 P39688 (/ISO)
Regulation of calcium ion import across plasma membrane GO:1905664
Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane.
1 P39688 (/IGI)
Positive regulation of ovarian follicle development GO:2000386
Any process that activates or increases the frequency, rate or extent of ovarian follicle development.
1 Q9WUD9 (/IMP)
Positive regulation of ovarian follicle development GO:2000386
Any process that activates or increases the frequency, rate or extent of ovarian follicle development.
1 P05480 (/ISO)
Positive regulation of lamellipodium morphogenesis GO:2000394
Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis.
1 P05480 (/ISO)
Positive regulation of DNA biosynthetic process GO:2000573
Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.
1 Q9WUD9 (/IMP)
Positive regulation of DNA biosynthetic process GO:2000573
Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.
1 P05480 (/ISO)
Positive regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000588
Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.
1 P05480 (/IMP)
Regulation of early endosome to late endosome transport GO:2000641
Any process that modulates the frequency, rate or extent of early endosome to late endosome transport.
1 P05480 (/ISO)
Negative regulation of anoikis GO:2000811
Any process that stops, prevents or reduces the frequency, rate or extent of anoikis.
1 P05480 (/ISO)
Positive regulation of cysteine-type endopeptidase activity GO:2001056
Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.
1 P39688 (/ISO)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 P05480 (/ISO)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
1 P39688 (/ISO)
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 P05480 (/ISO)
Regulation of caveolin-mediated endocytosis GO:2001286
Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis.
1 P05480 (/ISO)

There are 78 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
34 F1LM93 (/IDA) J3QRU1 (/IDA) J3QRU1 (/IDA) J3QRU1 (/IDA) J3QRU1 (/IDA) P05480 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA)
(24 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
33 P00523 (/TAS) P05480 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(23 more)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
29 F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA)
(19 more)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
28 F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA) F1NQU9 (/IDA)
(18 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
28 J3QRU1 (/IDA) J3QRU1 (/IDA) J3QRU1 (/IDA) J3QRU1 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA)
(18 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
27 F1LM93 (/TAS) P05480 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(17 more)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
18 P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA) P06241 (/IDA)
(8 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
17 P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP) P06241 (/IMP)
(7 more)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
17 P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS) P06241 (/TAS)
(7 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Perinuclear endoplasmic reticulum GO:0097038
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Glial cell projection GO:0097386
A prolongation or process extending from a glial cell.
17 P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS) P06241 (/ISS)
(7 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 P12931 (/IDA) P12931 (/IDA) P12931 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
6 P07947 (/HDA) P07947 (/HDA) P09769 (/HDA) P12931 (/HDA) P12931 (/HDA) P12931 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P05480 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q6EWH2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P05480 (/ISO) P14234 (/ISO) P39688 (/ISO) Q04736 (/ISO) Q04736 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P05480 (/ISO) P14234 (/ISO) P39688 (/ISO) Q04736 (/ISO) Q04736 (/ISO)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
5 P05480 (/IDA) P12931 (/IDA) P12931 (/IDA) P12931 (/IDA) Q9WUD9 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
5 F1LM93 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q9WUD9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P05480 (/IDA) P12931 (/IDA) P12931 (/IDA) P12931 (/IDA)
Actin filament GO:0005884
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
4 P05480 (/IDA) P39688 (/IDA) Q04736 (/IDA) Q04736 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
4 Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q9WUD9 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q9WUD9 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 P05480 (/IDA) Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
4 P05480 (/ISO) P39688 (/ISO) Q04736 (/ISO) Q04736 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
3 P12931 (/IDA) P12931 (/IDA) P12931 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
3 P12931 (/IDA) P12931 (/IDA) P12931 (/IDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
3 P12931 (/IDA) P12931 (/IDA) P12931 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
3 Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
Perinuclear endoplasmic reticulum GO:0097038
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
3 Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
Postsynaptic specialization, intracellular component GO:0099091
A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
3 P05480 (/ISO) Q04736 (/ISO) Q04736 (/ISO)
Postsynaptic density, intracellular component GO:0099092
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
3 Q62844 (/IDA) Q62844 (/IDA) Q62844 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P05480 (/ISO) P39688 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P00523 (/ISS) Q9WUD9 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 P07947 (/IDA) P07947 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 Q04736 (/ISO) Q04736 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 P07947 (/HDA) P07947 (/HDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 P05480 (/ISO) P39688 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P05480 (/ISO) P39688 (/ISO)
Postsynaptic specialization, intracellular component GO:0099091
A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 F1LM93 (/IDA) Q9WUD9 (/IDA)
Podosome GO:0002102
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
1 P05480 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P09769 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P39688 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P05480 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P05480 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P05480 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 P05480 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 P39688 (/ISO)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 P05480 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9WUD9 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P09769 (/ISS)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 P05480 (/ISO)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 P39688 (/IMP)
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
1 P09769 (/IDA)
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
1 P14234 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P39688 (/IMP)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 P05480 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P00523 (/IMP)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
1 P09769 (/TAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9WUD9 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P05480 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P39688 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 P39688 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P39688 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P39688 (/ISO)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
1 P39688 (/IDA)
Perinuclear endoplasmic reticulum GO:0097038
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
1 P39688 (/ISO)
Glial cell projection GO:0097386
A prolongation or process extending from a glial cell.
1 P39688 (/IDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P39688 (/IDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P39688 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9WUD9 (/EXP)
Postsynaptic density, intracellular component GO:0099092
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 P39688 (/ISO)