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CATH Superfamily 3.30.200.20

Phosphorylase Kinase; domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 131: Dual specificity protein kinase TTK

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mitogen-activated protein kinase kinase. [EC: 2.7.12.2]
ATP + a protein = ADP + a phosphoprotein.
  • A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation.
  • It is required for activation of EC 2.7.11.24.
  • Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
 37 A0A0L8VST2 A0A0L8VST2 A0A0L8VST2 A0A0L8VST2 A0A0L8VST2 A0A0L8VST2 A6ZXU3 A6ZXU3 A6ZXU3 A6ZXU3
(27 more...)
Dual-specificity kinase. [EC: 2.7.12.1]
ATP + a protein = ADP + a phosphoprotein.
  • This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
  • Formerly EC 2.7.1.37.
 4 P33981 P35761 Q4R945 Q8AYG3
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 1 Q54UL8
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