The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphorylase Kinase; domain 1
".
FunFam 1: Ephrin type-A receptor 5
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 52 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
27 |
D3ZZK3 (/IPI)
P28693 (/IPI)
P29317 (/IPI)
P29317 (/IPI)
P29319 (/IPI)
P29320 (/IPI)
P29320 (/IPI)
P29323 (/IPI)
P54757 (/IPI)
P54759 (/IPI)
(17 more) |
|
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
|
20 |
D3ZZK3 (/ISS)
O08680 (/ISS)
O13146 (/ISS)
O42422 (/ISS)
P29318 (/ISS)
P29319 (/ISS)
P54755 (/ISS)
P54756 (/ISS)
P54756 (/ISS)
P54757 (/ISS)
(10 more) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
17 |
B5M6R3 (/ISS)
D2HRP3 (/ISS)
D3ZZK3 (/ISS)
E1BER5 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
G7N911 (/ISS)
(7 more) |
|
DH domain binding GO:0097161
Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.
|
17 |
B5M6R3 (/ISS)
D2HRP3 (/ISS)
D3ZZK3 (/ISS)
E1BER5 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
G7N911 (/ISS)
(7 more) |
|
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
|
16 |
D3ZZK3 (/ISS)
P09759 (/ISS)
P28693 (/ISS)
P29323 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
Q07494 (/ISS)
Q07496 (/ISS)
(6 more) |
|
Ephrin receptor activity GO:0005003
Combining with an ephrin to initiate a change in cell activity.
|
9 | O13147 (/ISS) P29318 (/ISS) P54754 (/ISS) P54756 (/ISS) P54756 (/ISS) P54761 (/ISS) Q07498 (/ISS) Q60629 (/ISS) Q91735 (/ISS) |
|
Ephrin receptor activity GO:0005003
Combining with an ephrin to initiate a change in cell activity.
|
7 | P29319 (/IDA) P54753 (/IDA) P54757 (/IDA) P54760 (/IDA) P54760 (/IDA) P54760 (/IDA) P54763 (/IDA) |
|
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
5 | P29323 (/TAS) P54764 (/TAS) P54764 (/TAS) P54764 (/TAS) P54764 (/TAS) |
|
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
|
5 | P29317 (/IDA) P29317 (/IDA) P54760 (/IDA) P54760 (/IDA) P54760 (/IDA) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
4 | P54764 (/IDA) P54764 (/IDA) P54764 (/IDA) P54764 (/IDA) |
|
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
4 | O42422 (/ISS) P29323 (/ISS) Q15375 (/ISS) Q15375 (/ISS) |
|
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
|
4 | P29320 (/IDA) P29320 (/IDA) Q60629 (/IDA) Q61772 (/IDA) |
|
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
|
4 | P29323 (/TAS) P54754 (/TAS) P54763 (/TAS) Q8CBF3 (/TAS) |
|
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
|
4 | O42422 (/ISS) P54759 (/ISS) Q15375 (/ISS) Q15375 (/ISS) |
|
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
4 | P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) |
|
PH domain binding GO:0042731
Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
|
4 | P54764 (/IPI) P54764 (/IPI) P54764 (/IPI) P54764 (/IPI) |
|
DH domain binding GO:0097161
Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.
|
4 | P54764 (/IDA) P54764 (/IDA) P54764 (/IDA) P54764 (/IDA) |
|
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
|
4 | P54764 (/IPI) P54764 (/IPI) P54764 (/IPI) P54764 (/IPI) |
|
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
3 | P09759 (/IDA) P54759 (/IDA) P54763 (/IDA) |
|
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
|
3 | P54761 (/ISS) Q03145 (/ISS) Q1KL86 (/ISS) |
|
Ephrin receptor activity GO:0005003
Combining with an ephrin to initiate a change in cell activity.
|
3 | P54754 (/ISO) P54761 (/ISO) Q60629 (/ISO) |
|
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
|
3 | P54762 (/IDA) P54763 (/IDA) Q03137 (/IDA) |
|
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
|
3 | P54754 (/IDA) P54763 (/IDA) Q8CBF3 (/IDA) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
3 | A0A0G2JY48 (/IPI) P54763 (/IPI) Q8CBF3 (/IPI) |
|
Chemorepellent activity GO:0045499
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.
|
3 | P54759 (/ISS) Q15375 (/ISS) Q15375 (/ISS) |
|
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
2 | P09759 (/IMP) P54763 (/IMP) |
|
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
2 | Q61772 (/ISO) Q8CBF3 (/ISO) |
|
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
|
2 | P54761 (/ISO) Q03145 (/ISO) |
|
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
|
2 | P54756 (/NAS) P54756 (/NAS) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | P54763 (/IPI) Q03137 (/IPI) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
2 | P29317 (/HDA) P29317 (/HDA) |
|
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
|
2 | D3ZZK3 (/IDA) P54759 (/IDA) |
|
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
|
2 | Q03137 (/ISO) Q61772 (/ISO) |
|
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
1 | P54763 (/IPI) |
|
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
1 | P29323 (/ISS) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q03137 (/ISO) |
|
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
1 | P28693 (/TAS) |
|
Ephrin receptor activity GO:0005003
Combining with an ephrin to initiate a change in cell activity.
|
1 | P54759 (/NAS) |
|
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
|
1 | Q03137 (/IMP) |
|
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
|
1 | P29319 (/ISO) |
|
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
|
1 | Q8CBF3 (/ISO) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P54763 (/IPI) |
|
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
|
1 | Q61772 (/IMP) |
|
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | F1NHC7 (/IDA) |
|
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | Q03137 (/ISO) |
|
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
1 | P54763 (/IDA) |
|
PH domain binding GO:0042731
Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
|
1 | Q03137 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | P54763 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | P29323 (/ISS) |
|
Chemorepellent activity GO:0045499
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.
|
1 | Q61772 (/IDA) |
|
DH domain binding GO:0097161
Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.
|
1 | Q03137 (/ISO) |
|
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
|
1 | Q03137 (/ISO) |
There are 365 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
26 |
B5M6R3 (/ISS)
D2HRP3 (/ISS)
D3ZZK3 (/ISS)
E1BER5 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
G7N911 (/ISS)
(16 more) |
|
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
21 |
O08680 (/ISS)
O13146 (/ISS)
O13147 (/ISS)
O42422 (/ISS)
P09759 (/ISS)
P28693 (/ISS)
P29318 (/ISS)
P29323 (/ISS)
P54754 (/ISS)
P54755 (/ISS)
(11 more) |
|
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
20 |
B5M6R3 (/ISS)
D2HRP3 (/ISS)
D3ZZK3 (/ISS)
E1BER5 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
G7N911 (/ISS)
(10 more) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
20 |
D3ZZK3 (/ISS)
O08680 (/ISS)
O13146 (/ISS)
O13147 (/ISS)
P29318 (/ISS)
P29319 (/ISS)
P54754 (/ISS)
P54755 (/ISS)
P54756 (/ISS)
P54756 (/ISS)
(10 more) |
|
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
19 |
P29317 (/TAS)
P29317 (/TAS)
P29320 (/TAS)
P29320 (/TAS)
P29323 (/TAS)
P54753 (/TAS)
P54756 (/TAS)
P54756 (/TAS)
P54760 (/TAS)
P54760 (/TAS)
(9 more) |
|
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
18 |
P29317 (/IDA)
P29317 (/IDA)
P29319 (/IDA)
P29320 (/IDA)
P29320 (/IDA)
P54753 (/IDA)
P54757 (/IDA)
P54760 (/IDA)
P54760 (/IDA)
P54760 (/IDA)
(8 more) |
|
Positive regulation of Rho guanyl-nucleotide exchange factor activity GO:2001108
Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
|
17 |
B5M6R3 (/ISS)
D2HRP3 (/ISS)
D3ZZK3 (/ISS)
E1BER5 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
G7N911 (/ISS)
(7 more) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
16 |
O13147 (/ISS)
P09759 (/ISS)
P28693 (/ISS)
P29323 (/ISS)
P54753 (/ISS)
P54755 (/ISS)
P54756 (/ISS)
P54756 (/ISS)
P54757 (/ISS)
P54762 (/ISS)
(6 more) |
|
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
|
12 |
O13147 (/ISS)
P09759 (/ISS)
P28693 (/ISS)
P29323 (/ISS)
P54753 (/ISS)
P54762 (/ISS)
Q07494 (/ISS)
Q07498 (/ISS)
Q90344 (/ISS)
Q91571 (/ISS)
(2 more) |
|
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
12 |
O13147 (/ISS)
P09759 (/ISS)
P28693 (/ISS)
P29323 (/ISS)
P54753 (/ISS)
P54762 (/ISS)
Q07494 (/ISS)
Q07498 (/ISS)
Q90344 (/ISS)
Q91571 (/ISS)
(2 more) |
|
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
12 |
O13147 (/ISS)
P09759 (/ISS)
P28693 (/ISS)
P29323 (/ISS)
P54753 (/ISS)
P54762 (/ISS)
Q07494 (/ISS)
Q07498 (/ISS)
Q90344 (/ISS)
Q91571 (/ISS)
(2 more) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
10 | O08680 (/ISS) O13146 (/ISS) O13147 (/ISS) P29318 (/ISS) P29320 (/ISS) P29320 (/ISS) Q03145 (/ISS) Q07498 (/ISS) Q1KL86 (/ISS) Q91735 (/ISS) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
10 | P09759 (/IDA) P54753 (/IDA) P54760 (/IDA) P54760 (/IDA) P54760 (/IDA) P54762 (/IDA) P54764 (/IDA) P54764 (/IDA) P54764 (/IDA) P54764 (/IDA) |
|
Fasciculation of sensory neuron axon GO:0097155
The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
|
10 | O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29320 (/ISS) P29320 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) Q07496 (/ISS) |
|
Fasciculation of motor neuron axon GO:0097156
The collection of motor neuron axons into a bundle of rods, known as a fascicle.
|
10 | D3ZZK3 (/ISS) O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29320 (/ISS) P29320 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
9 | P09759 (/ISS) P28693 (/ISS) P29323 (/ISS) P54753 (/ISS) P54760 (/ISS) P54760 (/ISS) P54760 (/ISS) Q8CBF3 (/ISS) Q90344 (/ISS) |
|
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
|
9 | D3ZZK3 (/ISS) O13147 (/ISS) P54753 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) Q07498 (/ISS) Q91735 (/ISS) |
|
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
|
8 | O13147 (/ISS) O42422 (/ISS) P54754 (/ISS) P54759 (/ISS) Q07498 (/ISS) Q15375 (/ISS) Q15375 (/ISS) Q91735 (/ISS) |
|
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
8 | O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29319 (/ISS) P54755 (/ISS) P54756 (/ISS) P54756 (/ISS) P54757 (/ISS) |
|
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
8 | A0A2R8QJW7 (/IGI) F1RCR4 (/IGI) O73875 (/IGI) P54761 (/IGI) P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) |
|
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
8 | P29319 (/ISO) P54754 (/ISO) P54761 (/ISO) Q03137 (/ISO) Q03145 (/ISO) Q60629 (/ISO) Q61772 (/ISO) Q8CBF3 (/ISO) |
|
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
8 | O42422 (/ISS) P09759 (/ISS) P54759 (/ISS) Q07494 (/ISS) Q61772 (/ISS) Q8CBF3 (/ISS) Q91571 (/ISS) Q91736 (/ISS) |
|
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
|
7 | O13147 (/ISS) P28693 (/ISS) P29323 (/ISS) P54753 (/ISS) Q07498 (/ISS) Q90344 (/ISS) Q91735 (/ISS) |
|
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
7 | P29320 (/IDA) P29320 (/IDA) P54763 (/IDA) P54764 (/IDA) P54764 (/IDA) P54764 (/IDA) P54764 (/IDA) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
6 | D3ZZK3 (/IDA) P29320 (/IDA) P29320 (/IDA) P54753 (/IDA) Q03137 (/IDA) Q60629 (/IDA) |
|
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
6 | P09759 (/ISS) Q03145 (/ISS) Q07494 (/ISS) Q1KL86 (/ISS) Q91571 (/ISS) Q91736 (/ISS) |
|
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
5 | D3ZZK3 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Regulation of epithelial to mesenchymal transition GO:0010717
Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
5 | O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29320 (/ISS) P29320 (/ISS) |
|
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
5 | O42422 (/ISS) P29323 (/ISS) Q15375 (/ISS) Q15375 (/ISS) Q61772 (/ISS) |
|
Corticospinal tract morphogenesis GO:0021957
Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.
|
5 | D3ZZK3 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
|
5 | P09759 (/ISS) P54762 (/ISS) Q07494 (/ISS) Q91571 (/ISS) Q91736 (/ISS) |
|
Cell-substrate adhesion GO:0031589
The attachment of a cell to the underlying substrate via adhesion molecules.
|
5 | P09759 (/ISS) Q07494 (/ISS) Q8CBF3 (/ISS) Q91571 (/ISS) Q91736 (/ISS) |
|
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
5 | P09759 (/ISS) Q07494 (/ISS) Q8CBF3 (/ISS) Q91571 (/ISS) Q91736 (/ISS) |
|
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
|
5 | D3ZZK3 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Regulation of astrocyte differentiation GO:0048710
Any process that modulates the frequency, rate or extent of astrocyte differentiation.
|
5 | D3ZZK3 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Regulation of dendritic spine morphogenesis GO:0061001
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
5 | D3ZZK3 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
4 | P54754 (/IDA) P54763 (/IDA) Q60629 (/IDA) Q8CBF3 (/IDA) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
4 | P54754 (/IMP) P54763 (/IMP) Q03137 (/IMP) Q8CBF3 (/IMP) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
4 | O42422 (/ISS) P54759 (/ISS) Q15375 (/ISS) Q15375 (/ISS) |
|
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
4 | P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
4 | P29317 (/IMP) P29317 (/IMP) P29319 (/IMP) P54754 (/IMP) |
|
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
|
4 | P54755 (/ISS) P54756 (/ISS) P54756 (/ISS) P54757 (/ISS) |
|
Regulation of protein autophosphorylation GO:0031952
Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.
|
4 | O42422 (/ISS) P54759 (/ISS) Q15375 (/ISS) Q15375 (/ISS) |
|
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
|
4 | O13147 (/ISS) P54754 (/ISS) Q07498 (/ISS) Q91735 (/ISS) |
|
Regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281
Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.
|
4 | O42422 (/ISS) P54759 (/ISS) Q15375 (/ISS) Q15375 (/ISS) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
4 | P54754 (/ISO) P54761 (/ISO) Q03137 (/ISO) Q8CBF3 (/ISO) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
4 | P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) |
|
Regulation of focal adhesion assembly GO:0051893
Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
|
4 | O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29319 (/ISS) |
|
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
|
4 | P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
|
4 | O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29319 (/ISS) |
|
Neuron projection guidance GO:0097485
The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
4 | P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Neuron projection fasciculation GO:0106030
The collection of neuronal projections into a bundle of rods, known as a fascicle.
|
4 | P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Negative regulation of long-term synaptic potentiation GO:1900272
Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation.
|
4 | P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Positive regulation of amyloid-beta formation GO:1902004
Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
|
4 | P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) |
|
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961
Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
|
4 | P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) |
|
Negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051
Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
|
4 | P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) P54764 (/IGI) |
|
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
|
4 | P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Regulation of modification of synaptic structure GO:1905244
Any process that modulates the frequency, rate or extent of modification of synaptic structure.
|
4 | P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Positive regulation of Rho guanyl-nucleotide exchange factor activity GO:2001108
Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
|
4 | P54764 (/IDA) P54764 (/IDA) P54764 (/IDA) P54764 (/IDA) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
3 | P54754 (/IMP) P54761 (/IMP) P54763 (/IMP) |
|
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
|
3 | A0A2R8QJW7 (/IGI) F1RCR4 (/IGI) O73875 (/IGI) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
3 | P29317 (/ISS) P29317 (/ISS) Q1KL86 (/ISS) |
|
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
|
3 | P54760 (/IDA) P54760 (/IDA) P54760 (/IDA) |
|
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
3 | P54760 (/ISS) P54760 (/ISS) P54760 (/ISS) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
3 | P54760 (/IDA) P54760 (/IDA) P54760 (/IDA) |
|
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
|
3 | P54756 (/ISS) P54756 (/ISS) Q60629 (/ISS) |
|
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
|
3 | P29317 (/ISS) P29317 (/ISS) Q1KL86 (/ISS) |
|
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
3 | P54754 (/IDA) P54763 (/IDA) Q8CBF3 (/IDA) |
|
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
|
3 | P54756 (/ISS) P54756 (/ISS) Q60629 (/ISS) |
|
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
3 | P29320 (/IDA) P29320 (/IDA) Q60629 (/IDA) |
|
Mammary gland epithelial cell proliferation GO:0033598
The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
|
3 | P29317 (/ISS) P29317 (/ISS) Q1KL86 (/ISS) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
3 | P29319 (/ISO) P54754 (/ISO) Q03137 (/ISO) |
|
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
|
3 | P54759 (/ISS) Q15375 (/ISS) Q15375 (/ISS) |
|
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
|
3 | P29317 (/ISS) P29317 (/ISS) Q1KL86 (/ISS) |
|
Bone remodeling GO:0046849
The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
|
3 | P29317 (/ISS) P29317 (/ISS) Q1KL86 (/ISS) |
|
Branching morphogenesis of a nerve GO:0048755
The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).
|
3 | P54759 (/ISS) Q15375 (/ISS) Q15375 (/ISS) |
|
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
3 | Q15375 (/IDA) Q15375 (/IDA) Q61772 (/IDA) |
|
Negative chemotaxis GO:0050919
The directed movement of a motile cell or organism towards a lower concentration of a chemical.
|
3 | P54759 (/ISS) Q15375 (/ISS) Q15375 (/ISS) |
|
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
|
3 | P54754 (/IMP) P54763 (/IMP) Q8CBF3 (/IMP) |
|
Convergent extension GO:0060026
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.
|
3 | A0A2R8QJW7 (/IGI) F1RCR4 (/IGI) O73875 (/IGI) |
|
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
3 | P29317 (/IMP) P29317 (/IMP) Q8CBF3 (/IMP) |
|
Branching involved in mammary gland duct morphogenesis GO:0060444
The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
|
3 | P29317 (/ISS) P29317 (/ISS) Q1KL86 (/ISS) |
|
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
3 | P54754 (/IMP) P54763 (/IMP) Q8CBF3 (/IMP) |
|
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
3 | P54754 (/IMP) P54763 (/IMP) Q8CBF3 (/IMP) |
|
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
|
3 | P54756 (/ISS) P54756 (/ISS) P54757 (/ISS) |
|
Lens fiber cell morphogenesis GO:0070309
The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
|
3 | P29317 (/ISS) P29317 (/ISS) Q1KL86 (/ISS) |
|
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
3 | P54762 (/IDA) Q15375 (/IDA) Q15375 (/IDA) |
|
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
3 | Q03145 (/ISO) Q61772 (/ISO) Q8CBF3 (/ISO) |
|
Postsynaptic membrane assembly GO:0097104
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
|
3 | A0A0G2JY48 (/IDA) B2B9B0 (/IDA) F1MAJ0 (/IDA) |
|
Postsynaptic membrane assembly GO:0097104
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
|
3 | A0A0G2JY48 (/IMP) B2B9B0 (/IMP) F1MAJ0 (/IMP) |
|
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
3 | A0A0G2JY48 (/IMP) P29317 (/IMP) P29317 (/IMP) |
|
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
3 | P29319 (/ISO) P54763 (/ISO) Q03145 (/ISO) |
|
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
3 | P29323 (/ISS) Q03145 (/ISS) Q1KL86 (/ISS) |
|
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
|
2 | O73875 (/IMP) Q03145 (/IMP) |
|
Urogenital system development GO:0001655
The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.
|
2 | P54754 (/IMP) P54763 (/IMP) |
|
Urogenital system development GO:0001655
The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.
|
2 | P29323 (/ISS) P54753 (/ISS) |
|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
2 | F1Q9D9 (/IMP) O73878 (/IMP) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
2 | F1NHC7 (/IDA) P54763 (/IDA) |
|
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
2 | P29317 (/TAS) P29317 (/TAS) |
|
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
|
2 | P54754 (/IMP) P54763 (/IMP) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
2 | P29317 (/IDA) P29317 (/IDA) |
|
Regulation of lamellipodium assembly GO:0010591
Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
|
2 | P29317 (/IMP) P29317 (/IMP) |
|
Regulation of lamellipodium assembly GO:0010591
Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | P29320 (/IMP) P29320 (/IMP) |
|
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | P29319 (/IDA) Q03137 (/IDA) |
|
Skeletal muscle satellite cell activation GO:0014719
The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.
|
2 | P09759 (/ISS) P54762 (/ISS) |
|
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
2 | P54759 (/IDA) P54763 (/IDA) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
2 | P54754 (/ISO) Q03145 (/ISO) |
|
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
2 | P29319 (/ISO) Q03137 (/ISO) |
|
Optic nerve morphogenesis GO:0021631
The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
|
2 | P54763 (/IMP) Q8CBF3 (/IMP) |
|
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
|
2 | P54754 (/IDA) Q8CBF3 (/IDA) |
|
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
|
2 | P54763 (/IMP) Q8CBF3 (/IMP) |
|
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
|
2 | P09759 (/ISS) P54762 (/ISS) |
|
Neurogenesis GO:0022008
Generation of cells within the nervous system.
|
2 | P09759 (/ISS) P54762 (/ISS) |
|
Corpus callosum development GO:0022038
The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.
|
2 | P54754 (/IMP) P54763 (/IMP) |
|
Corpus callosum development GO:0022038
The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.
|
2 | P29323 (/ISS) P54753 (/ISS) |
|
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
|
2 | P54753 (/IDA) Q61772 (/IDA) |
|
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
|
2 | P29317 (/IMP) P29317 (/IMP) |
|
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
|
2 | F1RCL1 (/IGI) Q90ZN9 (/IGI) |
|
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
2 | P09759 (/ISS) P54762 (/ISS) |
|
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
|
2 | P29317 (/IDA) P29317 (/IDA) |
|
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
|
2 | P29317 (/IDA) P29317 (/IDA) |
|
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
Regulation of blood vessel endothelial cell migration GO:0043535
Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
|
2 | P29317 (/ISS) P29317 (/ISS) |
|
Negative regulation of endocytosis GO:0045806
Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
|
2 | P29320 (/IDA) P29320 (/IDA) |
|
CAMP metabolic process GO:0046058
The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
|
2 | P29317 (/IMP) P29317 (/IMP) |
|
CAMP metabolic process GO:0046058
The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
Camera-type eye morphogenesis GO:0048593
The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
|
2 | P54763 (/IMP) Q8CBF3 (/IMP) |
|
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
2 | P54756 (/IEP) P54756 (/IEP) |
|
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
|
2 | D3ZZK3 (/IMP) Q03137 (/IMP) |
|
Negative regulation of collateral sprouting of intact axon in response to injury GO:0048685
Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon.
|
2 | F1RCL1 (/IGI) Q90ZN9 (/IGI) |
|
Venous blood vessel morphogenesis GO:0048845
The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.
|
2 | O73875 (/IMP) P54761 (/IMP) |
|
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
|
2 | P29317 (/IMP) P29317 (/IMP) |
|
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
2 | O42422 (/ISS) P54759 (/ISS) |
|
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
|
2 | P54754 (/IDA) P54763 (/IDA) |
|
Detection of temperature stimulus involved in sensory perception of pain GO:0050965
The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.
|
2 | P09759 (/ISS) P54762 (/ISS) |
|
Regulation of focal adhesion assembly GO:0051893
Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
|
2 | P29320 (/IDA) P29320 (/IDA) |
|
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
2 | P29317 (/IDA) P29317 (/IDA) |
|
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
Roof of mouth development GO:0060021
The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
|
2 | P54754 (/IMP) P54763 (/IMP) |
|
Roof of mouth development GO:0060021
The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
|
2 | P29323 (/ISS) P54753 (/ISS) |
|
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
2 | Q03145 (/ISO) Q8CBF3 (/ISO) |
|
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
2 | P54757 (/IDA) P54763 (/IDA) |
|
Neural precursor cell proliferation GO:0061351
The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.
|
2 | P09759 (/ISS) P54762 (/ISS) |
|
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | P29317 (/IMP) P29317 (/IMP) |
|
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
|
2 | P29320 (/IDA) P29320 (/IDA) |
|
Response to growth factor GO:0070848
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
|
2 | P29317 (/IMP) P29317 (/IMP) |
|
Response to growth factor GO:0070848
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
|
2 | P29320 (/IMP) P29320 (/IMP) |
|
Cellular response to follicle-stimulating hormone stimulus GO:0071372
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.
|
2 | P29319 (/IDA) Q60629 (/IDA) |
|
Nephric duct morphogenesis GO:0072178
The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney.
|
2 | Q03137 (/IGI) Q61772 (/IGI) |
|
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
2 | P29317 (/IMP) P29317 (/IMP) |
|
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
2 | P29317 (/IMP) P29317 (/IMP) |
|
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
Fasciculation of sensory neuron axon GO:0097155
The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
|
2 | P29319 (/IMP) Q03137 (/IMP) |
|
Fasciculation of motor neuron axon GO:0097156
The collection of motor neuron axons into a bundle of rods, known as a fascicle.
|
2 | P29319 (/IMP) Q03137 (/IMP) |
|
Synapse pruning GO:0098883
A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.
|
2 | D3ZZK3 (/EXP) Q03137 (/EXP) |
|
Synapse pruning GO:0098883
A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.
|
2 | D3ZZK3 (/IDA) Q03137 (/IDA) |
|
Synapse pruning GO:0098883
A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.
|
2 | D3ZZK3 (/IMP) Q03137 (/IMP) |
|
Negative regulation of skeletal muscle satellite cell proliferation GO:1902723
Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation.
|
2 | P09759 (/ISS) P54762 (/ISS) |
|
Negative regulation of satellite cell differentiation GO:1902725
Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation.
|
2 | P09759 (/ISS) P54762 (/ISS) |
|
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
2 | P29320 (/IDA) P29320 (/IDA) |
|
Positive regulation of bicellular tight junction assembly GO:1903348
Any process that activates or increases the frequency, rate or extent of tight junction assembly.
|
2 | P29317 (/IMP) P29317 (/IMP) |
|
Regulation of modification of synaptic structure GO:1905244
Any process that modulates the frequency, rate or extent of modification of synaptic structure.
|
2 | D3ZZK3 (/IGI) Q03137 (/IGI) |
|
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
|
1 | P54763 (/IGI) |
|
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
|
1 | Q03145 (/IMP) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
1 | P54762 (/IDA) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
1 | Q8CBF3 (/ISO) |
|
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
1 | Q03145 (/IMP) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
1 | Q03145 (/IMP) |
|
Fever generation GO:0001660
The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.
|
1 | O08680 (/IEP) |
|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
1 | Q07496 (/NAS) |
|
Immunological synapse formation GO:0001771
The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
|
1 | P09759 (/IGI) |
|
Immunological synapse formation GO:0001771
The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
|
1 | Q8CBF3 (/ISO) |
|
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
|
1 | Q03145 (/IMP) |
|
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
|
1 | P54763 (/IDA) |
|
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
|
1 | P29323 (/ISS) |
|
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
1 | Q61772 (/IDA) |
|
Lymph vessel development GO:0001945
The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
|
1 | O73875 (/IMP) |
|
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
|
1 | P54761 (/ISO) |
|
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
|
1 | P54761 (/ISS) |
|
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043
The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.
|
1 | Q03145 (/IMP) |
|
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | P54761 (/IMP) |
|
Endocardial cushion development GO:0003197
The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
|
1 | P29319 (/IMP) |
|
Neural retina development GO:0003407
The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
|
1 | F1NHC7 (/IDA) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | Q03145 (/IMP) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | P54761 (/ISO) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | P54761 (/ISS) |
|
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
|
1 | P54757 (/IDA) |
|
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
|
1 | Q60629 (/ISO) |
|
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P54763 (/IDA) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | P29323 (/TAS) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q03137 (/IGI) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
1 | F1NHC7 (/IDA) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
1 | Q61772 (/IMP) |
|
Mesoderm migration involved in gastrulation GO:0007509
The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.
|
1 | F1Q9D9 (/IMP) |
|
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
|
1 | P54763 (/IGI) |
|
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
|
1 | P29323 (/ISS) |
|
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
|
1 | P54763 (/IMP) |
|
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
|
1 | P29323 (/ISS) |
|
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
|
1 | Q03137 (/IMP) |
|
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q03137 (/IMP) |
|
Glial cell migration GO:0008347
The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
|
1 | D3ZZK3 (/IMP) |
|
Glial cell migration GO:0008347
The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
|
1 | Q03137 (/ISO) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
1 | Q03145 (/ISO) |
|
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
|
1 | P54763 (/IMP) |
|
Regulation of lamellipodium assembly GO:0010591
Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
|
1 | Q03145 (/ISO) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | A0A0G2JY48 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P54763 (/ISO) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P29323 (/ISS) |
|
Regulation of epithelial to mesenchymal transition GO:0010717
Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
1 | P29319 (/IMP) |
|
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P29319 (/ISO) |
|
Notochord formation GO:0014028
The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.
|
1 | Q03145 (/IGI) |
|
Notochord formation GO:0014028
The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.
|
1 | Q03145 (/IMP) |
|
Skeletal muscle satellite cell activation GO:0014719
The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.
|
1 | Q8CBF3 (/IMP) |
|
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
1 | Q61772 (/ISO) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | P54753 (/IDA) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
1 | Q03145 (/IMP) |
|
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
1 | P54763 (/IMP) |
|
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
|
1 | P54757 (/IDA) |
|
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
|
1 | Q60629 (/ISO) |
|
Cranial nerve development GO:0021545
The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
|
1 | Q8CBF3 (/IMP) |
|
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
|
1 | Q60629 (/IDA) |
|
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
|
1 | Q03145 (/IMP) |
|
Corticospinal tract morphogenesis GO:0021957
Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.
|
1 | Q03137 (/IMP) |
|
Spinothalamic tract morphogenesis GO:0021963
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling.
|
1 | P28693 (/IDA) |
|
Neurogenesis GO:0022008
Generation of cells within the nervous system.
|
1 | Q8CBF3 (/IMP) |
|
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
|
1 | P54754 (/ISO) |
|
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
|
1 | Q8CBF3 (/IMP) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
1 | Q03145 (/IDA) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
1 | Q03145 (/IMP) |
|
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
|
1 | Q03145 (/ISO) |
|
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
|
1 | Q03145 (/IDA) |
|
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
1 | P29319 (/IGI) |
|
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
1 | Q61772 (/IMP) |
|
Cell-substrate adhesion GO:0031589
The attachment of a cell to the underlying substrate via adhesion molecules.
|
1 | P54762 (/IDA) |
|
Cell-substrate adhesion GO:0031589
The attachment of a cell to the underlying substrate via adhesion molecules.
|
1 | Q8CBF3 (/ISO) |
|
Positive regulation of synaptic plasticity GO:0031915
A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | P54763 (/IGI) |
|
Positive regulation of synaptic plasticity GO:0031915
A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | P29323 (/ISS) |
|
Regulation of protein autophosphorylation GO:0031952
Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.
|
1 | Q61772 (/IDA) |
|
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | O08680 (/IEP) |
|
Negative regulation of chemokine production GO:0032682
Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production.
|
1 | Q03145 (/IMP) |
|
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
|
1 | P54757 (/IMP) |
|
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
|
1 | Q60629 (/ISO) |
|
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | P29319 (/ISO) |
|
Mammary gland epithelial cell proliferation GO:0033598
The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
|
1 | Q03145 (/IMP) |
|
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
|
1 | Q03145 (/ISO) |
|
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | O08680 (/IEP) |
|
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
|
1 | P54753 (/IDA) |
|
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
|
1 | P54754 (/ISO) |
|
Segmentation GO:0035282
The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.
|
1 | Q07496 (/NAS) |
|
Angioblast cell migration involved in selective angioblast sprouting GO:0035475
The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations.
|
1 | O73875 (/IMP) |
|
Post-anal tail morphogenesis GO:0036342
The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.
|
1 | Q03145 (/IMP) |
|
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
|
1 | P54763 (/IMP) |
|
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
|
1 | P29323 (/ISS) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | P54759 (/IMP) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q61772 (/ISO) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | Q03137 (/IMP) |
|
Regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281
Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.
|
1 | Q61772 (/IDA) |
|
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
|
1 | Q03145 (/ISO) |
|
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
|
1 | Q03137 (/IDA) |
|
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
|
1 | Q61772 (/IMP) |
|
Regulation of blood vessel endothelial cell migration GO:0043535
Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
|
1 | Q03145 (/IDA) |
|
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
|
1 | Q03145 (/IDA) |
|
Negative regulation of endocytosis GO:0045806
Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
|
1 | P29319 (/ISO) |
|
CAMP metabolic process GO:0046058
The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
|
1 | Q03145 (/ISO) |
|
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | P54762 (/IDA) |
|
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | Q8CBF3 (/ISO) |
|
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
|
1 | P54763 (/IDA) |
|
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
|
1 | P29323 (/ISS) |
|
Bone remodeling GO:0046849
The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
|
1 | Q03145 (/IMP) |
|
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
1 | Q03145 (/IMP) |
|
Regulation of neuronal synaptic plasticity GO:0048168
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | P54763 (/IMP) |
|
Regulation of neuronal synaptic plasticity GO:0048168
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | P29323 (/ISS) |
|
Positive regulation of long-term neuronal synaptic plasticity GO:0048170
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
|
1 | P54763 (/IMP) |
|
Axial mesoderm formation GO:0048320
The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
|
1 | Q03145 (/IMP) |
|
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
|
1 | Q03145 (/IMP) |
|
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
|
1 | P54754 (/IMP) |
|
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
|
1 | P54753 (/ISS) |
|
Digestive tract morphogenesis GO:0048546
The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | P54754 (/IMP) |
|
Digestive tract morphogenesis GO:0048546
The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | P54753 (/ISS) |
|
Notochord morphogenesis GO:0048570
The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
|
1 | Q03145 (/IMP) |
|
Negative regulation of collateral sprouting GO:0048671
Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting.
|
1 | Q61772 (/IDA) |
|
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
|
1 | Q03137 (/ISO) |
|
Regulation of astrocyte differentiation GO:0048710
Any process that modulates the frequency, rate or extent of astrocyte differentiation.
|
1 | Q03137 (/IMP) |
|
Branching morphogenesis of a nerve GO:0048755
The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).
|
1 | Q61772 (/IMP) |
|
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
|
1 | Q03145 (/ISO) |
|
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
1 | Q61772 (/ISO) |
|
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
|
1 | Q03137 (/IMP) |
|
Negative regulation of axonogenesis GO:0050771
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
|
1 | P54763 (/IDA) |
|
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
|
1 | D3ZZK3 (/IMP) |
|
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
|
1 | Q03137 (/ISO) |
|
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
|
1 | Q8CBF3 (/IDA) |
|
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
|
1 | Q8CBF3 (/IMP) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | Q03137 (/ISO) |
|
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
1 | Q03145 (/IMP) |
|
Regulation of body fluid levels GO:0050878
Any process that modulates the levels of body fluids.
|
1 | P54763 (/IMP) |
|
Regulation of body fluid levels GO:0050878
Any process that modulates the levels of body fluids.
|
1 | P29323 (/ISS) |
|
Detection of temperature stimulus involved in sensory perception of pain GO:0050965
The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.
|
1 | Q8CBF3 (/IMP) |
|
Inactivation of MAPKK activity GO:0051389
Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK).
|
1 | P54763 (/IDA) |
|
Inactivation of MAPKK activity GO:0051389
Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK).
|
1 | P29323 (/ISS) |
|
Regulation of focal adhesion assembly GO:0051893
Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
|
1 | P29319 (/ISO) |
|
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | Q03145 (/ISO) |
|
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
|
1 | P54763 (/EXP) |
|
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
|
1 | P54763 (/IDA) |
|
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
|
1 | P54763 (/IMP) |
|
Negative regulation of synapse assembly GO:0051964
Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
|
1 | Q61772 (/IDA) |
|
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
|
1 | P54763 (/IDA) |
|
Notochord cell development GO:0060035
The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
|
1 | Q03145 (/IMP) |
|
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | P54762 (/IDA) |
|
Branching involved in mammary gland duct morphogenesis GO:0060444
The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
|
1 | Q03145 (/IMP) |
|
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | P09759 (/IGI) |
|
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | Q8CBF3 (/ISO) |
|
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | Q60629 (/ISO) |
|
Regulation of dendritic spine morphogenesis GO:0061001
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | Q03137 (/IMP) |
|
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
|
1 | Q03137 (/IGI) |
|
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
|
1 | Q60629 (/IDA) |
|
Neural precursor cell proliferation GO:0061351
The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.
|
1 | Q8CBF3 (/IMP) |
|
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
|
1 | O73878 (/IMP) |
|
Lens fiber cell morphogenesis GO:0070309
The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
|
1 | Q03145 (/IDA) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | P54763 (/IDA) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | P29323 (/ISS) |
|
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
|
1 | P29319 (/ISO) |
|
Response to growth factor GO:0070848
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
|
1 | Q03145 (/ISO) |
|
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
|
1 | P29319 (/ISO) |
|
Commissural neuron axon guidance GO:0071679
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
1 | P54763 (/IMP) |
|
Commissural neuron axon guidance GO:0071679
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
1 | P29323 (/ISS) |
|
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
1 | Q03145 (/ISO) |
|
Cochlea development GO:0090102
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
|
1 | Q03137 (/IMP) |
|
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
1 | Q03145 (/ISO) |
|
Postsynaptic membrane assembly GO:0097104
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
|
1 | P54763 (/ISO) |
|
Neuron projection guidance GO:0097485
The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q03137 (/IDA) |
|
Synapse pruning GO:0098883
A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.
|
1 | Q03137 (/ISO) |
|
Regulation of postsynapse organization GO:0099175
Any process that modulates the physical form of a postsynapse.
|
1 | Q61772 (/IDA) |
|
Regulation of postsynapse organization GO:0099175
Any process that modulates the physical form of a postsynapse.
|
1 | Q61772 (/IMP) |
|
Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission GO:0099557
Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.
|
1 | P54763 (/IMP) |
|
Synaptic membrane adhesion GO:0099560
The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
|
1 | P29319 (/IDA) |
|
Synaptic membrane adhesion GO:0099560
The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
|
1 | P29319 (/IMP) |
|
Neuron projection retraction GO:0106028
The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | P54763 (/IDA) |
|
Neuron projection fasciculation GO:0106030
The collection of neuronal projections into a bundle of rods, known as a fascicle.
|
1 | Q03137 (/IDA) |
|
Negative regulation of long-term synaptic potentiation GO:1900272
Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation.
|
1 | Q03137 (/IGI) |
|
Positive regulation of long-term synaptic potentiation GO:1900273
Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.
|
1 | P54763 (/IMP) |
|
Positive regulation of long-term synaptic potentiation GO:1900273
Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.
|
1 | P29323 (/ISS) |
|
Regulation of neuron death GO:1901214
Any process that modulates the frequency, rate or extent of neuron death.
|
1 | P54762 (/IMP) |
|
Regulation of neuron death GO:1901214
Any process that modulates the frequency, rate or extent of neuron death.
|
1 | Q8CBF3 (/ISO) |
|
Negative regulation of lymphangiogenesis GO:1901491
Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis.
|
1 | Q03145 (/IMP) |
|
Positive regulation of amyloid-beta formation GO:1902004
Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
|
1 | Q03137 (/ISO) |
|
Negative regulation of skeletal muscle satellite cell proliferation GO:1902723
Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation.
|
1 | Q8CBF3 (/IMP) |
|
Negative regulation of satellite cell differentiation GO:1902725
Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation.
|
1 | Q8CBF3 (/IMP) |
|
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961
Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
|
1 | Q03137 (/ISO) |
|
Negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051
Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
|
1 | Q03137 (/ISO) |
|
Positive regulation of bicellular tight junction assembly GO:1903348
Any process that activates or increases the frequency, rate or extent of tight junction assembly.
|
1 | Q03145 (/ISO) |
|
Positive regulation of aorta morphogenesis GO:1903849
Any process that activates or increases the frequency, rate or extent of aorta morphogenesis.
|
1 | P54761 (/IMP) |
|
Pericyte cell differentiation GO:1904238
The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell.
|
1 | Q03145 (/IMP) |
|
Cellular response to forskolin GO:1904322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
|
1 | Q60629 (/IDA) |
|
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
|
1 | Q03137 (/IGI) |
|
Negative regulation of NMDA glutamate receptor activity GO:1904782
Any process that stops, prevents or reduces the frequency, rate or extent of NMDA glutamate receptor activity.
|
1 | P54763 (/IMP) |
|
Negative regulation of NMDA glutamate receptor activity GO:1904782
Any process that stops, prevents or reduces the frequency, rate or extent of NMDA glutamate receptor activity.
|
1 | P29323 (/ISS) |
|
Positive regulation of NMDA glutamate receptor activity GO:1904783
Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity.
|
1 | P54763 (/IMP) |
|
Positive regulation of NMDA glutamate receptor activity GO:1904783
Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity.
|
1 | P29323 (/ISS) |
|
Regulation of modification of synaptic structure GO:1905244
Any process that modulates the frequency, rate or extent of modification of synaptic structure.
|
1 | Q03137 (/ISO) |
|
Positive regulation of T cell costimulation GO:2000525
Any process that activates or increases the frequency, rate or extent of T cell costimulation.
|
1 | P54761 (/IGI) |
|
Positive regulation of Rho guanyl-nucleotide exchange factor activity GO:2001108
Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
|
1 | Q03137 (/ISO) |
There are 113 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
26 |
O08680 (/ISS)
O13146 (/ISS)
O13147 (/ISS)
P09759 (/ISS)
P28693 (/ISS)
P29318 (/ISS)
P29319 (/ISS)
P29323 (/ISS)
P54754 (/ISS)
P54761 (/ISS)
(16 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
24 |
P28693 (/TAS)
P29317 (/TAS)
P29317 (/TAS)
P29319 (/TAS)
P29320 (/TAS)
P29320 (/TAS)
P29323 (/TAS)
P54753 (/TAS)
P54756 (/TAS)
P54756 (/TAS)
(14 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
20 |
B5M6R3 (/ISS)
D2HRP3 (/ISS)
E1BER5 (/ISS)
F6TGX8 (/ISS)
F6WF88 (/ISS)
F6XVY7 (/ISS)
F7AJ26 (/ISS)
G7N911 (/ISS)
G7N911 (/ISS)
G7N911 (/ISS)
(10 more) |
|
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
13 |
D3ZZK3 (/ISS)
P09759 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
Q07494 (/ISS)
Q07496 (/ISS)
Q8CBF3 (/ISS)
Q91571 (/ISS)
(3 more) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
12 |
D3ZZK3 (/IDA)
P29317 (/IDA)
P29317 (/IDA)
P29320 (/IDA)
P29320 (/IDA)
P54753 (/IDA)
P54760 (/IDA)
P54760 (/IDA)
P54760 (/IDA)
P54762 (/IDA)
(2 more) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
12 |
D3ZZK3 (/ISS)
P28693 (/ISS)
P29323 (/ISS)
P54755 (/ISS)
P54756 (/ISS)
P54756 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
(2 more) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
11 |
D3ZZK3 (/ISS)
P28693 (/ISS)
P29323 (/ISS)
P54755 (/ISS)
P54757 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
P54764 (/ISS)
Q60629 (/ISS)
(1 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
9 | B1AKC9 (/IDA) D3ZZK3 (/IDA) P29317 (/IDA) P29317 (/IDA) P29323 (/IDA) P54756 (/IDA) P54756 (/IDA) P54757 (/IDA) P54762 (/IDA) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
9 | A0A0G2JY48 (/IDA) B2B9B0 (/IDA) D3ZZK3 (/IDA) F1MAJ0 (/IDA) P54759 (/IDA) P54763 (/IDA) Q03137 (/IDA) Q61772 (/IDA) Q8CBF3 (/IDA) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
8 | A0A0G2JY48 (/IMP) B2B9B0 (/IMP) D3ZZK3 (/IMP) F1MAJ0 (/IMP) P54763 (/IMP) Q03137 (/IMP) Q61772 (/IMP) Q8CBF3 (/IMP) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
6 | P29323 (/TAS) P54753 (/TAS) P54760 (/TAS) P54760 (/TAS) P54760 (/TAS) P54762 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | P29323 (/TAS) P54753 (/TAS) P54760 (/TAS) P54760 (/TAS) P54760 (/TAS) P54762 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
6 | P29319 (/ISO) P54754 (/ISO) P54761 (/ISO) Q03137 (/ISO) Q03145 (/ISO) Q8CBF3 (/ISO) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
6 | D3ZZK3 (/IDA) P54756 (/IDA) P54756 (/IDA) P54759 (/IDA) P54763 (/IDA) Q03137 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P54763 (/ISO) Q03137 (/ISO) Q03145 (/ISO) Q60629 (/ISO) Q8CBF3 (/ISO) |
|
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
4 | O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29319 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P54764 (/NAS) P54764 (/NAS) P54764 (/NAS) P54764 (/NAS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
4 | D3ZZK3 (/IDA) P29317 (/IDA) P29317 (/IDA) Q03145 (/IDA) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
4 | P54757 (/IDA) P54763 (/IDA) Q03137 (/IDA) Q8CBF3 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
4 | P54756 (/IDA) P54756 (/IDA) P54759 (/IDA) P54763 (/IDA) |
|
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
4 | P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
|
4 | P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) P54764 (/ISS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
4 | P54760 (/HDA) P54760 (/HDA) P54760 (/HDA) P54762 (/HDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P54755 (/ISS) P54757 (/ISS) Q60629 (/ISS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | P54754 (/TAS) P54763 (/TAS) Q8CBF3 (/TAS) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
3 | Q03137 (/ISO) Q60629 (/ISO) Q61772 (/ISO) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
3 | D3ZZK3 (/EXP) P54763 (/EXP) Q03137 (/EXP) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
3 | P54763 (/ISO) Q03137 (/ISO) Q61772 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | B1AKC9 (/IDA) P29323 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | A0A0B4J1T8 (/IDA) Q9UF33 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | D3ZZK3 (/IDA) Q8CBF3 (/IDA) |
|
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
2 | P29320 (/IDA) P29320 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | D3ZZK3 (/IDA) P54762 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | Q03137 (/ISO) Q8CBF3 (/ISO) |
|
Rough endoplasmic reticulum GO:0005791
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
|
2 | P54756 (/IDA) P54756 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | P29317 (/HDA) P29317 (/HDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | P29317 (/IDA) P29317 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | P54756 (/IDA) P54756 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P29317 (/HDA) P29317 (/HDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | Q03137 (/ISO) Q03145 (/ISO) |
|
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
2 | P29317 (/IDA) P29317 (/IDA) |
|
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
Leading edge membrane GO:0031256
The portion of the plasma membrane surrounding the leading edge of a motile cell.
|
2 | P29317 (/IDA) P29317 (/IDA) |
|
Leading edge membrane GO:0031256
The portion of the plasma membrane surrounding the leading edge of a motile cell.
|
2 | Q03145 (/ISS) Q1KL86 (/ISS) |
|
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
2 | D3ZZK3 (/IDA) P54759 (/IDA) |
|
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
2 | Q03137 (/ISO) Q61772 (/ISO) |
|
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
2 | P54762 (/IDA) Q03137 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | Q60629 (/ISO) Q61772 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | P54756 (/IDA) P54756 (/IDA) |
|
Tight junction GO:0070160
A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.
|
2 | P29317 (/IDA) P29317 (/IDA) |
|
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
|
2 | P54759 (/IDA) Q03137 (/IDA) |
|
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P54763 (/IDA) Q03137 (/IDA) |
|
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P54763 (/IDA) Q03137 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P54763 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q62413 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q03137 (/ISO) |
|
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
|
1 | D3ZZK3 (/IDA) |
|
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
|
1 | Q03137 (/ISO) |
|
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
1 | P29319 (/ISO) |
|
Rough endoplasmic reticulum GO:0005791
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
|
1 | Q60629 (/ISO) |
|
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | D3ZZK3 (/IDA) |
|
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | Q03137 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P54762 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8CBF3 (/ISO) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q61772 (/IC) |
|
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
1 | Q60629 (/IDA) |
|
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
1 | Q03137 (/IMP) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | Q03145 (/ISO) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q60629 (/ISO) |
|
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
1 | D3ZZK3 (/IDA) |
|
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
1 | Q03137 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q8CBF3 (/IDA) |
|
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
1 | Q03145 (/ISO) |
|
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
1 | D3ZZK3 (/IDA) |
|
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
1 | Q03137 (/ISO) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q60629 (/ISO) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | D3ZZK3 (/NAS) |
|
Leading edge membrane GO:0031256
The portion of the plasma membrane surrounding the leading edge of a motile cell.
|
1 | Q03145 (/ISO) |
|
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
1 | Q8CBF3 (/ISO) |
|
Filopodium tip GO:0032433
The end of a filopodium distal to the body of the cell.
|
1 | Q8CBF3 (/IDA) |
|
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
|
1 | D3ZZK3 (/IDA) |
|
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
|
1 | Q03137 (/ISO) |
|
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
1 | D3ZZK3 (/IDA) |
|
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
1 | Q03137 (/ISO) |
|
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
|
1 | D3ZZK3 (/IDA) |
|
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
|
1 | Q03137 (/ISO) |
|
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
1 | D3ZZK3 (/IDA) |
|
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
1 | Q03137 (/ISO) |
|
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
|
1 | D3ZZK3 (/IDA) |
|
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
|
1 | Q03137 (/ISO) |
|
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
|
1 | D3ZZK3 (/IDA) |
|
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
|
1 | Q03137 (/ISO) |
|
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
|
1 | D3ZZK3 (/IDA) |
|
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
|
1 | Q03137 (/ISO) |
|
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
1 | Q8CBF3 (/IDA) |
|
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
1 | P54763 (/NAS) |
|
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
|
1 | P54759 (/IDA) |
|
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
|
1 | Q61772 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q60629 (/ISO) |
|
Tight junction GO:0070160
A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.
|
1 | Q03145 (/ISO) |
|
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
1 | Q60629 (/IDA) |
|
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
|
1 | Q61772 (/ISO) |
|
Hippocampal mossy fiber to CA3 synapse GO:0098686
One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
|
1 | P54759 (/IDA) |
|
Hippocampal mossy fiber to CA3 synapse GO:0098686
One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
|
1 | Q61772 (/ISO) |
|
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
|
1 | P29319 (/IDA) |
|
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
|
1 | P29323 (/TAS) |
|
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
1 | P29319 (/IDA) |
|
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
1 | P29319 (/IMP) |
|
Integral component of postsynaptic specialization membrane GO:0099060
The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P54759 (/IDA) |
|
Integral component of postsynaptic specialization membrane GO:0099060
The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q61772 (/ISO) |
|
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P54759 (/IDA) |
|
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q61772 (/ISO) |