The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Classic Zinc Finger
".
FunFam 74: Tripartite motif containing 66
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 53 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
14 |
A0A0B4KGE5 (/IDA)
A0A0B4KH12 (/IDA)
A0A0B4KHG7 (/IDA)
A0A0B4KHT0 (/IDA)
A8WHL4 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
Q13263 (/IDA)
Q13263 (/IDA)
(4 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
12 |
O15164 (/IPI)
O15164 (/IPI)
O15164 (/IPI)
Q13263 (/IPI)
Q13263 (/IPI)
Q62318 (/IPI)
Q62318 (/IPI)
Q64127 (/IPI)
Q924W6 (/IPI)
Q99PP7 (/IPI)
(2 more) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
7 | A0A0B4KGE5 (/ISS) A0A0B4KH12 (/ISS) A0A0B4KHG7 (/ISS) A0A0B4KHT0 (/ISS) A8WHL4 (/ISS) Q9U3Y7 (/ISS) Q9VDK5 (/ISS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
7 | A0A0B4KGE5 (/ISM) A0A0B4KH12 (/ISM) A0A0B4KHG7 (/ISM) A0A0B4KHT0 (/ISM) A8WHL4 (/ISM) Q9U3Y7 (/ISM) Q9VDK5 (/ISM) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
6 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) Q62318 (/IDA) Q62318 (/IDA) Q64127 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
6 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) Q13263 (/IDA) Q13263 (/IDA) Q64127 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
5 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) Q13263 (/IDA) Q13263 (/IDA) |
|
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
4 | O15164 (/IPI) O15164 (/IPI) O15164 (/IPI) Q64127 (/IPI) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | Q13263 (/IDA) Q13263 (/IDA) Q62318 (/IDA) Q62318 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
4 | O08629 (/ISS) Q13263 (/ISS) Q13263 (/ISS) Q64127 (/ISS) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | Q62318 (/ISO) Q62318 (/ISO) Q64127 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | O15164 (/TAS) O15164 (/TAS) O15164 (/TAS) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
3 | Q62318 (/IDA) Q62318 (/IDA) Q64127 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
3 | Q62318 (/ISO) Q62318 (/ISO) Q64127 (/ISO) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
3 | O15164 (/TAS) O15164 (/TAS) O15164 (/TAS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
3 | Q62318 (/ISO) Q62318 (/ISO) Q64127 (/ISO) |
|
Estrogen response element binding GO:0034056
Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen.
|
3 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) |
|
Krueppel-associated box domain binding GO:0035851
Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.
|
3 | O08629 (/ISS) Q62318 (/ISS) Q62318 (/ISS) |
|
Lysine-acetylated histone binding GO:0070577
Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.
|
3 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
3 | O08629 (/ISS) Q62318 (/ISS) Q62318 (/ISS) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q13263 (/IDA) Q13263 (/IDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | Q13263 (/HDA) Q13263 (/HDA) |
|
SUMO transferase activity GO:0019789
Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.
|
2 | Q13263 (/EXP) Q13263 (/EXP) |
|
SUMO transferase activity GO:0019789
Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
2 | Q13263 (/IDA) Q13263 (/IDA) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Krueppel-associated box domain binding GO:0035851
Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.
|
2 | Q13263 (/IDA) Q13263 (/IDA) |
|
Krueppel-associated box domain binding GO:0035851
Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Chromo shadow domain binding GO:0070087
Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.
|
2 | Q13263 (/IPI) Q13263 (/IPI) |
|
Chromo shadow domain binding GO:0070087
Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
2 | Q13263 (/IDA) Q13263 (/IDA) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
1 | Q64127 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q64127 (/ISO) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q9UPN9 (/TAS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q64127 (/ISS) |
|
Nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
|
1 | Q64127 (/IDA) |
|
Nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
|
1 | F1P4C7 (/ISS) |
|
Estrogen response element binding GO:0034056
Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen.
|
1 | Q64127 (/ISO) |
|
Estrogen response element binding GO:0034056
Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen.
|
1 | Q64127 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q924W6 (/IPI) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | Q64127 (/IDA) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q64127 (/IDA) |
|
Co-SMAD binding GO:0070410
Interacting selectively and non-covalently with a common mediator SMAD signaling protein.
|
1 | Q9UPN9 (/IPI) |
|
Co-SMAD binding GO:0070410
Interacting selectively and non-covalently with a common mediator SMAD signaling protein.
|
1 | Q99PP7 (/ISO) |
|
Co-SMAD binding GO:0070410
Interacting selectively and non-covalently with a common mediator SMAD signaling protein.
|
1 | Q99PP7 (/ISS) |
|
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
|
1 | Q9UPN9 (/IPI) |
|
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
|
1 | Q99PP7 (/ISO) |
|
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
|
1 | Q99PP7 (/ISS) |
|
Lysine-acetylated histone binding GO:0070577
Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.
|
1 | Q64127 (/ISO) |
|
Lysine-acetylated histone binding GO:0070577
Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.
|
1 | Q64127 (/ISS) |
There are 89 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
8 | A0A0B4KGE5 (/ISS) A0A0B4KH12 (/ISS) A0A0B4KHG7 (/ISS) A0A0B4KHT0 (/ISS) A8WHL4 (/ISS) Q99PP7 (/ISS) Q9U3Y7 (/ISS) Q9VDK5 (/ISS) |
|
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
7 | A0A0B4KGE5 (/IMP) A0A0B4KH12 (/IMP) A0A0B4KHG7 (/IMP) A0A0B4KHT0 (/IMP) A8WHL4 (/IMP) Q9U3Y7 (/IMP) Q9VDK5 (/IMP) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
7 | A0A0B4KGE5 (/IMP) A0A0B4KH12 (/IMP) A0A0B4KHG7 (/IMP) A0A0B4KHT0 (/IMP) A8WHL4 (/IMP) Q9U3Y7 (/IMP) Q9VDK5 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | Q13263 (/IDA) Q13263 (/IDA) Q62318 (/IDA) Q62318 (/IDA) Q64127 (/IDA) Q924W6 (/IDA) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
5 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) Q64127 (/IDA) Q9UPN9 (/IDA) |
|
Positive regulation of methylation-dependent chromatin silencing GO:0090309
Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
|
5 | O08629 (/ISS) Q13263 (/ISS) Q13263 (/ISS) Q62318 (/ISS) Q62318 (/ISS) |
|
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
4 | O15164 (/IMP) O15164 (/IMP) O15164 (/IMP) Q64127 (/IMP) |
|
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
|
4 | O15164 (/IMP) O15164 (/IMP) O15164 (/IMP) Q64127 (/IMP) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
4 | Q13263 (/IDA) Q13263 (/IDA) Q62318 (/IDA) Q62318 (/IDA) |
|
Positive regulation of methylation-dependent chromatin silencing GO:0090309
Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
|
4 | Q13263 (/IMP) Q13263 (/IMP) Q62318 (/IMP) Q62318 (/IMP) |
|
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
3 | O08629 (/ISS) Q13263 (/ISS) Q13263 (/ISS) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
3 | O15164 (/TAS) O15164 (/TAS) O15164 (/TAS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | Q62318 (/IDA) Q62318 (/IDA) Q64127 (/IDA) |
|
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
|
3 | O08629 (/ISS) Q62318 (/ISS) Q62318 (/ISS) |
|
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
3 | O08629 (/ISS) Q62318 (/ISS) Q62318 (/ISS) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
3 | O15164 (/IMP) O15164 (/IMP) O15164 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | O08629 (/ISS) Q13263 (/ISS) Q13263 (/ISS) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
3 | Q62318 (/IDA) Q62318 (/IDA) Q64127 (/IDA) |
|
Cellular response to estrogen stimulus GO:0071391
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
|
3 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q62318 (/IDA) Q62318 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q62318 (/IGI) Q62318 (/IGI) |
|
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
2 | Q62318 (/IMP) Q62318 (/IMP) |
|
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | Q62318 (/IDA) Q62318 (/IDA) |
|
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
2 | Q13263 (/IDA) Q13263 (/IDA) |
|
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
2 | Q13263 (/TAS) Q13263 (/TAS) |
|
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
|
2 | Q13263 (/IMP) Q13263 (/IMP) |
|
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
|
2 | Q62318 (/IMP) Q62318 (/IMP) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
2 | Q64127 (/ISO) Q99PP7 (/ISO) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
2 | Q13263 (/IDA) Q13263 (/IDA) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
2 | Q13263 (/IDA) Q13263 (/IDA) |
|
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
DNA methylation involved in embryo development GO:0043045
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression.
|
2 | Q62318 (/IMP) Q62318 (/IMP) |
|
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
2 | Q62318 (/IDA) Q62318 (/IDA) |
|
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
2 | Q62318 (/IMP) Q62318 (/IMP) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | Q62318 (/IGI) Q62318 (/IGI) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
|
2 | Q13263 (/IDA) Q13263 (/IDA) |
|
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045869
Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.
|
2 | Q62318 (/IDA) Q62318 (/IDA) |
|
Negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045869
Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.
|
2 | Q62318 (/IGI) Q62318 (/IGI) |
|
Negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045869
Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.
|
2 | Q62318 (/IMP) Q62318 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q62318 (/IMP) Q62318 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q62318 (/IDA) Q62318 (/IDA) |
|
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
2 | Q13263 (/IDA) Q13263 (/IDA) |
|
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Convergent extension involved in axis elongation GO:0060028
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.
|
2 | Q62318 (/IMP) Q62318 (/IMP) |
|
Embryonic placenta morphogenesis GO:0060669
The process in which the embryonic placenta is generated and organized.
|
2 | Q62318 (/IMP) Q62318 (/IMP) |
|
Positive regulation of methylation-dependent chromatin silencing GO:0090309
Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Negative regulation of DNA demethylation GO:1901536
Any process that stops, prevents or reduces the frequency, rate or extent of DNA demethylation.
|
2 | Q62318 (/IMP) Q62318 (/IMP) |
|
Negative regulation of viral release from host cell GO:1902187
Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell.
|
2 | Q13263 (/IDA) Q13263 (/IDA) |
|
Negative regulation of viral release from host cell GO:1902187
Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell.
|
2 | Q62318 (/ISO) Q62318 (/ISO) |
|
Regulation of genetic imprinting GO:2000653
Any process that modulates the frequency, rate or extent of genetic imprinting.
|
2 | Q62318 (/IMP) Q62318 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q9UPN9 (/TAS) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q64127 (/IGI) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q64127 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q64127 (/IGI) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q64127 (/IMP) |
|
Regulation of transforming growth factor beta receptor signaling pathway GO:0017015
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.
|
1 | Q9UPN9 (/IDA) |
|
Regulation of transforming growth factor beta receptor signaling pathway GO:0017015
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.
|
1 | Q99PP7 (/ISO) |
|
Regulation of transforming growth factor beta receptor signaling pathway GO:0017015
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.
|
1 | Q99PP7 (/ISS) |
|
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
1 | Q64127 (/ISO) |
|
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
1 | Q6E2N3 (/IGI) |
|
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
1 | Q6E2N3 (/IMP) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | Q9UPN9 (/IDA) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | Q99PP7 (/ISO) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | Q99PP7 (/ISS) |
|
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
1 | Q6E2N3 (/IMP) |
|
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
|
1 | Q64127 (/ISO) |
|
Fin development GO:0033333
The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure.
|
1 | Q6E2N3 (/IMP) |
|
Regulation of transcription elongation from RNA polymerase II promoter GO:0034243
Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
|
1 | Q6E2N3 (/IGI) |
|
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
|
1 | Q6E2N3 (/IMP) |
|
Post-embryonic hemopoiesis GO:0035166
The stages of blood cell formation that take place after completion of embryonic development.
|
1 | Q6E2N3 (/IMP) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
1 | Q64127 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9UPN9 (/NAS) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q64127 (/IGI) |
|
Developmental pigmentation GO:0048066
The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
|
1 | Q6E2N3 (/IMP) |
|
Macrophage chemotaxis GO:0048246
The movement of a macrophage in response to an external stimulus.
|
1 | Q6E2N3 (/IMP) |
|
Calcium ion homeostasis GO:0055074
Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
|
1 | Q64127 (/IMP) |
|
Primitive hemopoiesis GO:0060215
A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells.
|
1 | Q6E2N3 (/IMP) |
|
Regulation of vitamin D receptor signaling pathway GO:0070562
Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity.
|
1 | Q64127 (/IMP) |
|
Cellular response to estrogen stimulus GO:0071391
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
|
1 | Q64127 (/ISO) |
|
Cellular response to estrogen stimulus GO:0071391
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
|
1 | Q64127 (/ISS) |
|
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
|
1 | Q64127 (/IGI) |
|
Macrophage migration GO:1905517
The orderly movement of a macrophage from one site to another.
|
1 | Q6E2N3 (/IMP) |
|
Neutrophil migration GO:1990266
The movement of a neutrophil within or between different tissues and organs of the body.
|
1 | Q6E2N3 (/IMP) |
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
18 |
A0A0B4KGE5 (/IDA)
A0A0B4KH12 (/IDA)
A0A0B4KHG7 (/IDA)
A0A0B4KHT0 (/IDA)
A8WHL4 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
Q13263 (/IDA)
Q13263 (/IDA)
(8 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
11 |
A0A024R784 (/IDA)
A0A024R784 (/IDA)
B5MCJ9 (/IDA)
O15016 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
Q13263 (/IDA)
Q13263 (/IDA)
Q62318 (/IDA)
(1 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q62318 (/ISO) Q62318 (/ISO) Q64127 (/ISO) Q99PP7 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | Q62318 (/ISO) Q62318 (/ISO) Q64127 (/ISO) Q924W6 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O08629 (/ISS) Q13263 (/ISS) Q13263 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O15164 (/TAS) O15164 (/TAS) O15164 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q13263 (/TAS) Q13263 (/TAS) Q9UPN9 (/TAS) |
|
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
|
3 | Q62318 (/IDA) Q62318 (/IDA) Q64127 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | O15164 (/TAS) O15164 (/TAS) O15164 (/TAS) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
3 | O08629 (/ISS) Q13263 (/ISS) Q13263 (/ISS) |
|
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
2 | Q62318 (/IDA) Q62318 (/IDA) |
|
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
|
2 | Q62318 (/IDA) Q62318 (/IDA) |
|
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
|
2 | B5MCJ9 (/IDA) O15016 (/IDA) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
2 | Q62318 (/IDA) Q62318 (/IDA) |
|
Perichromatin fibrils GO:0005726
Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts.
|
1 | Q64127 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q64127 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | F1P4C7 (/ISS) |
|
Chromocenter GO:0010369
A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure.
|
1 | Q924W6 (/IDA) |
|
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
|
1 | Q924W6 (/ISO) |
