The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Domain 2, N(10)-formyltetrahydrofolate synthetase
".
FunFam 4: C1-tetrahydrofolate synthase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Formate-tetrahydrofolate ligase activity GO:0004329
Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
|
3 | P07245 (/IMP) P07245 (/IMP) P07245 (/IMP) |
|
Methenyltetrahydrofolate cyclohydrolase activity GO:0004477
Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
|
3 | P07245 (/IMP) P07245 (/IMP) P07245 (/IMP) |
|
Methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.
|
3 | P07245 (/IMP) P07245 (/IMP) P07245 (/IMP) |
|
Formate-tetrahydrofolate ligase activity GO:0004329
Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
|
2 | P09440 (/IDA) P09440 (/IDA) |
|
Methenyltetrahydrofolate cyclohydrolase activity GO:0004477
Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
|
2 | P09440 (/IDA) P09440 (/IDA) |
|
Methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.
|
2 | P09440 (/IDA) P09440 (/IDA) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Folic acid-containing compound metabolic process GO:0006760
The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.
|
3 | P07245 (/IMP) P07245 (/IMP) P07245 (/IMP) |
|
Purine nucleobase biosynthetic process GO:0009113
The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
|
3 | P07245 (/IMP) P07245 (/IMP) P07245 (/IMP) |
|
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
|
2 | P09440 (/IMP) P09440 (/IMP) |
|
Folic acid biosynthetic process GO:0046656
The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid.
|
2 | P09440 (/IDA) P09440 (/IDA) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P07245 (/HDA) P07245 (/HDA) P07245 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | P07245 (/HDA) P07245 (/HDA) P07245 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P09440 (/HDA) P09440 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P09440 (/IDA) P09440 (/IDA) |
