The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Domain 2, N(10)-formyltetrahydrofolate synthetase
".
FunFam 2: C-1-tetrahydrofolate synthase, cytoplasmic
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Formate-tetrahydrofolate ligase activity GO:0004329
Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
|
2 | P11586 (/TAS) P27653 (/TAS) |
|
Methenyltetrahydrofolate cyclohydrolase activity GO:0004477
Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
|
2 | P11586 (/TAS) P27653 (/TAS) |
|
Methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity GO:0004486
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.
|
2 | P11586 (/TAS) P27653 (/TAS) |
|
Formate-tetrahydrofolate ligase activity GO:0004329
Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
|
1 | P11586 (/IDA) |
|
Formate-tetrahydrofolate ligase activity GO:0004329
Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
|
1 | Q922D8 (/IMP) |
|
Formate-tetrahydrofolate ligase activity GO:0004329
Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
|
1 | Q922D8 (/ISO) |
|
Formate-tetrahydrofolate ligase activity GO:0004329
Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
|
1 | P11586 (/ISS) |
|
Formate-tetrahydrofolate ligase activity GO:0004329
Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
|
1 | C8VIX6 (/RCA) |
|
Methenyltetrahydrofolate cyclohydrolase activity GO:0004477
Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
|
1 | P11586 (/IDA) |
|
Methenyltetrahydrofolate cyclohydrolase activity GO:0004477
Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
|
1 | Q922D8 (/ISO) |
|
Methenyltetrahydrofolate cyclohydrolase activity GO:0004477
Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
|
1 | C8VIX6 (/RCA) |
|
Methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity GO:0004486
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.
|
1 | P11586 (/IDA) |
|
Methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity GO:0004486
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.
|
1 | Q922D8 (/ISO) |
|
Methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0004487
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
|
1 | Q922D8 (/IDA) |
|
Methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0004487
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
|
1 | P11586 (/ISS) |
|
Methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.
|
1 | C8VIX6 (/RCA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P11586 (/IPI) |
There are 36 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Neutrophil homeostasis GO:0001780
The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
1 | Q922D8 (/IMP) |
|
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
1 | Q922D8 (/IMP) |
|
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
1 | P11586 (/ISS) |
|
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
|
1 | Q922D8 (/IMP) |
|
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
|
1 | P11586 (/ISS) |
|
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
1 | Q922D8 (/IMP) |
|
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
1 | P11586 (/ISS) |
|
One-carbon metabolic process GO:0006730
The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
|
1 | P27653 (/IEP) |
|
One-carbon metabolic process GO:0006730
The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
|
1 | P11586 (/IMP) |
|
One-carbon metabolic process GO:0006730
The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
|
1 | Q922D8 (/ISO) |
|
One-carbon metabolic process GO:0006730
The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
|
1 | C8VIX6 (/RCA) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | Q922D8 (/IMP) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | P11586 (/ISS) |
|
Serine family amino acid metabolic process GO:0009069
The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
|
1 | Q922D8 (/IMP) |
|
Serine family amino acid metabolic process GO:0009069
The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
|
1 | P11586 (/ISS) |
|
Serine family amino acid biosynthetic process GO:0009070
The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
|
1 | P11586 (/IMP) |
|
Serine family amino acid biosynthetic process GO:0009070
The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
|
1 | Q922D8 (/ISO) |
|
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
1 | P11586 (/IMP) |
|
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
1 | Q922D8 (/ISO) |
|
Nucleotide metabolic process GO:0009117
The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
|
1 | P27653 (/IEP) |
|
10-formyltetrahydrofolate biosynthetic process GO:0009257
The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.
|
1 | P11586 (/IDA) |
|
10-formyltetrahydrofolate biosynthetic process GO:0009257
The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.
|
1 | Q922D8 (/IMP) |
|
10-formyltetrahydrofolate biosynthetic process GO:0009257
The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.
|
1 | Q922D8 (/ISO) |
|
10-formyltetrahydrofolate biosynthetic process GO:0009257
The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.
|
1 | P11586 (/ISS) |
|
Transsulfuration GO:0019346
The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.
|
1 | Q922D8 (/IMP) |
|
Response to nitrogen dioxide GO:0035713
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.
|
1 | P27653 (/IEP) |
|
Tetrahydrofolate interconversion GO:0035999
The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
|
1 | P11586 (/IDA) |
|
Tetrahydrofolate interconversion GO:0035999
The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
|
1 | Q922D8 (/IMP) |
|
Tetrahydrofolate interconversion GO:0035999
The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
|
1 | Q922D8 (/ISO) |
|
Tetrahydrofolate interconversion GO:0035999
The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
|
1 | P11586 (/ISS) |
|
Tetrahydrofolate metabolic process GO:0046653
The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
|
1 | P27653 (/TAS) |
|
Folic acid metabolic process GO:0046655
The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
1 | P11586 (/TAS) |
|
Embryonic neurocranium morphogenesis GO:0048702
The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain.
|
1 | P11586 (/ISS) |
|
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
|
1 | P11586 (/ISS) |
|
Somite development GO:0061053
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
1 | Q922D8 (/IMP) |
|
Somite development GO:0061053
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
1 | P11586 (/ISS) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | F5H2F4 (/IDA) P11586 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P27653 (/TAS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q922D8 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P11586 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q922D8 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P11586 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P11586 (/HDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P11586 (/HDA) |
