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CATH Superfamily 3.30.1490.190

Ferric-uptake regulator, C-terminal dimerisarion domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ferric-uptake regulator, C-terminal dimerisarion domain

The Ferric uptake regulator (Fur) family includes metal ion uptake regulator proteins, which are responsible for controlling the intracellular concentration of iron in many bacteria. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+ PMID:9680209, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+ PMID:18259067,PMID:16553888.

Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a C-terminal dimerisation domain. This entry represents the dimerisation domain in which three antiparallel beta-strands are covering a long alpha-helix PMID:12581348.

PMID:9680209 PMID:18259067 PMID:16553888 PMID:12581348

GO Diversity

Unique GO annotations
33 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
14481 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 55
Domain clusters (>95% seq id): 12
Domain clusters (>35% seq id): 7
Unique PDBs: 23
Alignments
Structural Clusters (5A): 2
Structural Clusters (9A): 1
FunFam Clusters: 30
Function
Unique EC:
Unique GO: 33
Taxonomy
Unique Species: 14481