The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
K Homology domain, type 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 68: IGF-II mRNA-binding protein, isoform D

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
6 E1JJM0 (/IDA) M9NF14 (/IDA) Q0KHU2 (/IDA) Q8IGK4 (/IDA) Q8IR99 (/IDA) Q9VZ69 (/IDA)
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
1 M9NF14 (/IPI)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
6 E1JJM0 (/IC) M9NF14 (/IC) Q0KHU2 (/IC) Q8IGK4 (/IC) Q8IR99 (/IC) Q9VZ69 (/IC)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
6 E1JJM0 (/IMP) M9NF14 (/IMP) Q0KHU2 (/IMP) Q8IGK4 (/IMP) Q8IR99 (/IMP) Q9VZ69 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
6 E1JJM0 (/IEP) M9NF14 (/IEP) Q0KHU2 (/IEP) Q8IGK4 (/IEP) Q8IR99 (/IEP) Q9VZ69 (/IEP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
6 E1JJM0 (/IMP) M9NF14 (/IMP) Q0KHU2 (/IMP) Q8IGK4 (/IMP) Q8IR99 (/IMP) Q9VZ69 (/IMP)
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
6 E1JJM0 (/IMP) M9NF14 (/IMP) Q0KHU2 (/IMP) Q8IGK4 (/IMP) Q8IR99 (/IMP) Q9VZ69 (/IMP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
6 E1JJM0 (/IMP) M9NF14 (/IMP) Q0KHU2 (/IMP) Q8IGK4 (/IMP) Q8IR99 (/IMP) Q9VZ69 (/IMP)
Positive regulation of axon regeneration GO:0048680
Any process that activates, maintains or increases the rate of axon regeneration.
6 E1JJM0 (/IMP) M9NF14 (/IMP) Q0KHU2 (/IMP) Q8IGK4 (/IMP) Q8IR99 (/IMP) Q9VZ69 (/IMP)
Synaptic growth at neuromuscular junction GO:0051124
The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates.
6 E1JJM0 (/IMP) M9NF14 (/IMP) Q0KHU2 (/IMP) Q8IGK4 (/IMP) Q8IR99 (/IMP) Q9VZ69 (/IMP)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
1 M9NF14 (/IDA)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 E1JJM0 (/HDA) M9NF14 (/HDA) Q0KHU2 (/HDA) Q8IGK4 (/HDA) Q8IR99 (/HDA) Q9VZ69 (/HDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
6 E1JJM0 (/IDA) M9NF14 (/IDA) Q0KHU2 (/IDA) Q8IGK4 (/IDA) Q8IR99 (/IDA) Q9VZ69 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
6 E1JJM0 (/IDA) M9NF14 (/IDA) Q0KHU2 (/IDA) Q8IGK4 (/IDA) Q8IR99 (/IDA) Q9VZ69 (/IDA)
Precatalytic spliceosome GO:0071011
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
6 E1JJM0 (/HDA) M9NF14 (/HDA) Q0KHU2 (/HDA) Q8IGK4 (/HDA) Q8IR99 (/HDA) Q9VZ69 (/HDA)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
6 E1JJM0 (/HDA) M9NF14 (/HDA) Q0KHU2 (/HDA) Q8IGK4 (/HDA) Q8IR99 (/HDA) Q9VZ69 (/HDA)
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