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CATH Superfamily 3.30.1370.10

K Homology domain, type 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
K Homology domain, type 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: poly(RC)-binding protein 2 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 25 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
 141 O19048 (/ISS) O19048 (/ISS) O19048 (/ISS) O19048 (/ISS) O19048 (/ISS) O19048 (/ISS) O19048 (/ISS) O19048 (/ISS) O19048 (/ISS) O19048 (/ISS)
(131 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 131 I3LEC2 (/IPI) P60335 (/IPI) P60335 (/IPI) P60335 (/IPI) P60335 (/IPI) P60335 (/IPI) P60335 (/IPI) P60335 (/IPI) P60335 (/IPI) P60335 (/IPI)
(121 more)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
 94 P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA)
(84 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
 70 P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO)
(60 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
 61 P57721 (/HDA) Q15365 (/HDA) Q15365 (/HDA) Q15365 (/HDA) Q15365 (/HDA) Q15365 (/HDA) Q15365 (/HDA) Q15365 (/HDA) Q15365 (/HDA) Q15365 (/HDA)
(51 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
 60 Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA)
(50 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
 47 P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA)
(37 more)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
 47 P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO)
(37 more)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
 47 Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS)
(37 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
 47 Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS) Q5E9A3 (/ISS)
(37 more)
Showing 1 to 10 of 25 entries

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Viral RNA genome replication GO:0039694
The replication of a viral RNA genome.
 70 P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO)
(60 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
 60 Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS)
(50 more)
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
 60 Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS) Q15365 (/TAS)
(50 more)
Viral RNA genome replication GO:0039694
The replication of a viral RNA genome.
 60 Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA)
(50 more)
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
 47 P60335 (/TAS) P60335 (/TAS) P60335 (/TAS) P60335 (/TAS) P60335 (/TAS) P60335 (/TAS) P60335 (/TAS) P60335 (/TAS) P60335 (/TAS) P60335 (/TAS)
(37 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
 47 P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA)
(37 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
 23 Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO)
(13 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
 23 Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS)
(13 more)
Negative regulation of defense response to virus GO:0050687
Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.
 23 Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO) Q61990 (/ISO)
(13 more)
Negative regulation of defense response to virus GO:0050687
Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.
 23 Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS) Q61990 (/ISS)
(13 more)
Showing 1 to 10 of 19 entries

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
 107 Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA)
(97 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 107 P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA)
(97 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 107 Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA)
(97 more)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
 94 Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA)
(84 more)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
 94 Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA) Q15365 (/IDA)
(84 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 83 P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA) P60335 (/IDA)
(73 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
 70 P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO)
(60 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 70 P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO)
(60 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 70 P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO) P60335 (/ISO)
(60 more)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
 61 D4A8D6 (/EXP) Q4V8F6 (/EXP) Q4V8F6 (/EXP) Q4V8F6 (/EXP) Q4V8F6 (/EXP) Q4V8F6 (/EXP) Q4V8F6 (/EXP) Q4V8F6 (/EXP) Q4V8F6 (/EXP) Q4V8F6 (/EXP)
(51 more)
Showing 1 to 10 of 23 entries
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