The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
K Homology domain, type 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 27: insulin-like growth factor 2 mRNA-binding protein ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
28 O00425 (/IDA) O00425 (/IDA) O00425 (/IDA) O00425 (/IDA) O73932 (/IDA) O73932 (/IDA) Q8CGX0 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(18 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
26 O00425 (/IPI) O00425 (/IPI) O00425 (/IPI) O00425 (/IPI) O73932 (/IPI) O73932 (/IPI) Q9CPN8 (/IPI) Q9NZI8 (/IPI) Q9NZI8 (/IPI) Q9NZI8 (/IPI)
(16 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
23 O00425 (/HDA) O00425 (/HDA) O00425 (/HDA) O00425 (/HDA) Q9NZI8 (/HDA) Q9NZI8 (/HDA) Q9NZI8 (/HDA) Q9NZI8 (/HDA) Q9NZI8 (/HDA) Q9NZI8 (/HDA)
(13 more)
MRNA 5'-UTR binding GO:0048027
Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule.
23 O00425 (/IDA) O00425 (/IDA) O00425 (/IDA) O00425 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(13 more)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
17 Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(7 more)
Translation regulator activity GO:0045182
Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
17 Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(7 more)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
16 O42254 (/ISS) O57526 (/ISS) O57526 (/ISS) O73932 (/ISS) O73932 (/ISS) O88477 (/ISS) Q08CK7 (/ISS) Q08CK7 (/ISS) Q5RB68 (/ISS) Q5SF07 (/ISS)
(6 more)
Translation regulator activity GO:0045182
Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
6 O00425 (/ISS) O00425 (/ISS) O00425 (/ISS) O00425 (/ISS) Q9Y6M1 (/ISS) Q9Y6M1 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 O00425 (/TAS) O00425 (/TAS) O00425 (/TAS) O00425 (/TAS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
4 A0A091N3Z3 (/ISS) A0A093GA70 (/ISS) O88477 (/ISS) Q8CGX0 (/ISS)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
3 O88477 (/ISO) Q5SF07 (/ISO) Q9CPN8 (/ISO)
MRNA 5'-UTR binding GO:0048027
Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule.
3 O88477 (/ISO) Q5SF07 (/ISO) Q9CPN8 (/ISO)
MRNA 5'-UTR binding GO:0048027
Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule.
2 Q5RB68 (/ISS) Q5SF07 (/ISS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 O42254 (/IMP)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 O88477 (/ISO)
Translation regulator activity GO:0045182
Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
1 O88477 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of cytokine biosynthetic process GO:0042035
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
23 O00425 (/IC) O00425 (/IC) O00425 (/IC) O00425 (/IC) Q9NZI8 (/IC) Q9NZI8 (/IC) Q9NZI8 (/IC) Q9NZI8 (/IC) Q9NZI8 (/IC) Q9NZI8 (/IC)
(13 more)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
23 O00425 (/TAS) O00425 (/TAS) O00425 (/TAS) O00425 (/TAS) Q9NZI8 (/TAS) Q9NZI8 (/TAS) Q9NZI8 (/TAS) Q9NZI8 (/TAS) Q9NZI8 (/TAS) Q9NZI8 (/TAS)
(13 more)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
18 O42254 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(8 more)
Regulation of mRNA stability involved in response to stress GO:0010610
Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance.
17 Q9NZI8 (/IMP) Q9NZI8 (/IMP) Q9NZI8 (/IMP) Q9NZI8 (/IMP) Q9NZI8 (/IMP) Q9NZI8 (/IMP) Q9NZI8 (/IMP) Q9NZI8 (/IMP) Q9NZI8 (/IMP) Q9NZI8 (/IMP)
(7 more)
CRD-mediated mRNA stabilization GO:0070934
An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
17 Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(7 more)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
8 A0A091N3Z3 (/ISS) A0A093GA70 (/ISS) O00425 (/ISS) O00425 (/ISS) O00425 (/ISS) O00425 (/ISS) Q9Y6M1 (/ISS) Q9Y6M1 (/ISS)
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
6 O00425 (/TAS) O00425 (/TAS) O00425 (/TAS) O00425 (/TAS) Q9Y6M1 (/TAS) Q9Y6M1 (/TAS)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
4 O00425 (/TAS) O00425 (/TAS) O00425 (/TAS) O00425 (/TAS)
Neural retina development GO:0003407
The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
2 Q08CK7 (/IMP) Q08CK7 (/IMP)
Regulation of mRNA stability involved in response to stress GO:0010610
Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance.
2 O88477 (/ISS) Q8CGX0 (/ISS)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 A0A091N3Z3 (/ISS) A0A093GA70 (/ISS)
RNA localization GO:0006403
A process in which RNA is transported to, or maintained in, a specific location.
1 Q8CGX0 (/IMP)
RNA localization GO:0006403
A process in which RNA is transported to, or maintained in, a specific location.
1 O88477 (/ISO)
Regulation of mRNA stability involved in response to stress GO:0010610
Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance.
1 O88477 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 O42254 (/IMP)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 O88477 (/ISO)
Pallium cell proliferation in forebrain GO:0022013
The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population.
1 O88477 (/IMP)
CRD-mediated mRNA stabilization GO:0070934
An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
1 O88477 (/ISO)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
1 O88477 (/IMP)

There are 31 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
23 O00425 (/IDA) O00425 (/IDA) O00425 (/IDA) O00425 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(13 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
23 O00425 (/IDA) O00425 (/IDA) O00425 (/IDA) O00425 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(13 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
23 O00425 (/TAS) O00425 (/TAS) O00425 (/TAS) O00425 (/TAS) Q9NZI8 (/TAS) Q9NZI8 (/TAS) Q9NZI8 (/TAS) Q9NZI8 (/TAS) Q9NZI8 (/TAS) Q9NZI8 (/TAS)
(13 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
17 Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(7 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
17 Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(7 more)
CRD-mediated mRNA stability complex GO:0070937
A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.
17 Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(7 more)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
17 Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA) Q9NZI8 (/IDA)
(7 more)
CRD-mediated mRNA stability complex GO:0070937
A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.
5 O42254 (/ISS) O88477 (/ISS) Q08CK7 (/ISS) Q08CK7 (/ISS) Q8CGX0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 A0A091N3Z3 (/ISS) A0A093GA70 (/ISS) Q5RB68 (/ISS) Q5SF07 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 O00425 (/TAS) O00425 (/TAS) O00425 (/TAS) O00425 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O42254 (/IDA) Q9Y6M1 (/IDA) Q9Y6M1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O88477 (/ISO) Q5SF07 (/ISO) Q9CPN8 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O88477 (/ISO) Q5SF07 (/ISO) Q9CPN8 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q5RB68 (/ISS) Q5SF07 (/ISS)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2 Q9Y6M1 (/IDA) Q9Y6M1 (/IDA)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2 Q5RB68 (/ISS) Q5SF07 (/ISS)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
2 O88477 (/ISS) Q8CGX0 (/ISS)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
2 A0A091N3Z3 (/ISS) A0A093GA70 (/ISS)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
2 A0A091N3Z3 (/ISS) A0A093GA70 (/ISS)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
2 O73932 (/IPI) O73932 (/IPI)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
2 O88477 (/ISS) Q8CGX0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q5SF07 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O88477 (/ISO)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
1 Q5SF07 (/ISO)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
1 O88477 (/ISO)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 O42254 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q8CGX0 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 O88477 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 O42254 (/IDA)
CRD-mediated mRNA stability complex GO:0070937
A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.
1 O88477 (/ISO)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
1 O88477 (/ISO)
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