The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
K Homology domain, type 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1far upstream element-binding protein 1 isoform X1Mex-3 RNA-binding family member DRNA-binding protein Nova-1 isoform 1vigilin isoform X1far upstream element-binding protein 2Tudor and KH domain containing, isoform CRA_avigilin isoform X1SC:2Putative splicing factor 1protein quaking isoform X2protein quaking isoform X1SC:3Polyribonucleotide nucleotidyltransferaseKRR1 small subunit processome componentKRR1 small subunit processome componentexosome complex component RRP40vigilin isoform X1KH domain proteinExosome complex component Rrp4Exosome complex component RRP40KH type 1 domain proteinSC:4poly(RC)-binding protein 2 isoform X1Fragile X mental retardation 1, isoform CRA_epoly(RC)-binding protein 2 isoform X1Mex-3 RNA-binding family member BFar upstream element-binding protein 1 isoform X1vigilin isoform X1RNA-binding protein Nova-1 isoform 1Branchpoint-bridging protein-like proteinHeterogeneous nuclear ribonucleoprotein K, likePolyribonucleotide nucleotidyltransferase 1, mitochondrialvigilin isoform X1SC:5far upstream element-binding protein 1 isoform X1KH domain-containing 4, pre-mRNA-splicing factorvigilin isoform X1Vigilin isoform X1SC:6KH domain-containing protein 3poly(RC)-binding protein 2 isoform X1Ribonuclease YRNA-binding protein PNO1far upstream element-binding protein 1 isoform X1Fragile X mental retardation syndrome-related protein 1RNA-binding protein Nova-1 isoform 1Heterogeneous nuclear ribonucleoprotein K, likeHeterogeneous nuclear ribonucleoprotein K, likeInsulin-like growth factor 2 mRNA-binding protein 3insulin-like growth factor 2 mRNA-binding protein 3 isoform X1ankyrin repeat and KH domain-containing protein 1 isoform X2KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoformX2ankyrin repeat domain-containing protein 17 isoform X1synaptic functional regulator FMR1 isoform X2synaptic functional regulator FMR1 isoform X2KH RNA binding domain containing, signal transduction associated 1KH domain proteinKH domain-containing protein At2g38610KH domain-containing proteinKH domain-containing 4, pre-mRNA-splicing factorHigh density lipoprotein binding proteinsplicing factor-like protein 1RNA-binding protein PNO1 isoform X2Putative kh domain-containing proteinKep1, isoform AFragile X mental retardation syndrome-related protein 1Fragile X mental retardation protein 1Tudor and KH domain containingHigh density lipoprotein binding proteinpoly(RC)-binding protein 4 isoform X1Far upstream element binding protein 3High density lipoprotein binding proteinA-kinase anchor protein 1, mitochondrialprotein bicaudal C homolog 1 isoform X1KH domain-containing proteinKH domain containing 4, pre-mRNA splicing factorHigh density lipoprotein binding proteinIGF-II mRNA-binding protein, isoform DZinc finger CCCH domain-containing protein 52Uncharacterized proteinKH domain containing 1 likeUncharacterized protein, isoform ATranscription or splicing factor-like proteinSmall subunit rRNA processing KH domain protein, putativeKRR1 small subunit processome componentvigilin isoform X2Uncharacterized protein, isoform Adevelopmental pluripotency-associated 5 protein-likeRNA binding proteinRNA binding proteinRNA-binding protein PNO1DEAD (Asp-Glu-Ala-Asp) box polypeptide 43KH domain-containing, RNA-binding, signal transduction-associated protein 1 isoform X3KH domain-containing, RNA-binding, signal transduction-associated protein 1 isoform X3Oocyte-expressed protein homologKH domain containing 3 like, subcortical maternal complex memberUncharacterized protein, isoform ABnaC09g50550D proteinKRR1 small subunit processome componentPutative exosome complex exonuclease Rrp40PRE-binding proteinKH domain-containing proteinExosome complex component RRP40, putativeKH domain-containing proteinSplicing factor-like protein 1 isoform APbp2pPbp2pPutative branch point binding proteinActivating signal cointegrator 1 complex subunit 1Cleavage and polyadenylation specificity factor subunit 4Pbp2pUncharacterized proteinProtein CBG12765Scp160pScp160pDEAD box polypeptide 43 (Predicted)Heterogeneous nuclear rnp K-like protein 2Uncharacterized protein, isoform AUncharacterized protein, isoform AScp160pP-element somatic inhibitor, isoform AScp160pRNA-binding KH domain-containing proteinPoly(rC) binding protein 4Heterogeneous nuclear rnp K-like protein 2Uncharacterized protein, isoform DMeiotic recombination 1 proteinScp160pKH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X5Scp160pScp160pProtein CBR-SFA-1RNA-binding KH domain-containing proteinHeterogeneous nuclear ribonucleoprotein K, isoform BPre-rRNA-processing protein PNO1YLL032C-like proteinExosome complex exonuclease RRP40RNA-binding protein, putativeUncharacterized protein, isoform AUncharacterized protein, isoform BRE73736pRNA-binding protein, putativeKRR1 small subunit processome componentKH type 1 domain proteinExosome complex exonuclease RRP40, putativeRNA-binding KH domain-containing proteinKRR1 small subunit processome componentAGAP004145-PAPartner of Nob1Drosophila dodeca-satellite protein 1KH domain-containing proteinHeterogeneous nuclear rnp K-like protein 2FUBP1 isoform 1Protein CBG01583Uncharacterized proteinDrosophila dodeca-satellite protein 1Protein CBG06045Vigilin 1KH domain containing protein, putativeRNA-binding KH domain-containing proteinRNA-binding KH domain-containing proteinRNA-binding proteinKH homology domain-containing protein 1CDrosophila dodeca-satellite protein 1Putative eukaryotic LigTBranchpoint-bridging protein, putativeRNA-binding protein rnc1KRR1 small subunit processome componentKH domain-containing, RNA-binding, signal transduction-associated protein 3Protein CBG07980Far upstream element (FUSE)-binding protein 3Vigilin 1Exosome complex component Rrp4Exosome non-catalytic core subunitProtein CBR-NUO-2Vigilin 1Exosomal 3'-5' exoribonuclease complex subunit, putativeUncharacterized proteinTudor and KH domain-containing protein homologZinc finger CCCH domain-containing protein 52Tudor and KH domain-containing protein homologUncharacterized proteinHydrolaseDDX53 isoform 1Uncharacterized proteinUncharacterized proteinTudor and KH domain-containing protein homologKH domain containing 4, pre-mRNA splicing factorYALI0C05324pKH homology domain-containing protein 4-likeKRR1 small subunit processome componentKH homology domain-containing protein 4-likeYALI0C05324pProtein CBG16603Putative UPF0469 proteinKH domain-containing, RNA-binding, signal transduction-associated protein 3Protein CBG10565KH domain-containing proteinHigh density lipoprotein-binding protein aPredicted proteinPredicted proteinLOC553525 proteinSynaptic functional regulator FMR1Uncharacterized proteinVigilin 1Protein CBR-NUO-2Vigilin 1Uncharacterized proteinVigilin 1Uncharacterized proteinUncharacterized proteinUncharacterized proteinKRR1 small subunit processome component homolog-like proteinKRR1 small subunit processome component homolog-like proteinPolyribonucleotide nucleotidyltransferase, putativeUncharacterized proteinPredicted proteinAGAP004351-PAUncharacterized proteinATP-dependent RNA helicase p62-like ProteinVigilin 1Uncharacterized proteinVigilin 1RNA-binding protein rnc1LD29992pUncharacterized proteinUncharacterized proteinKRR1 small subunit processome componentPredicted proteinUncharacterized proteinUncharacterized proteinFar upstream element-binding protein 2KRR1 small subunit processome componentKH domain containing proteinKH domain containing proteinUncharacterized proteinPredicted proteinU1 snRNP-associated protein usp108Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinHeterogeneous nuclear RibonucleoProtein (HnRNP) K homologUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinPredicted proteinLD38872pEG:EG0003.2 protein (Fbgn0014870;psi protein)Hdlbp protein
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FunFam 20: RNA-binding protein Nova-1 isoform 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
12 P51513 (/HDA) Q9UNW9 (/HDA) Q9UNW9 (/HDA) Q9UNW9 (/HDA) Q9UNW9 (/HDA) Q9UNW9 (/HDA) Q9UNW9 (/HDA) Q9UNW9 (/HDA) Q9UNW9 (/HDA) Q9UNW9 (/HDA)
(2 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
11 Q9UNW9 (/NAS) Q9UNW9 (/NAS) Q9UNW9 (/NAS) Q9UNW9 (/NAS) Q9UNW9 (/NAS) Q9UNW9 (/NAS) Q9UNW9 (/NAS) Q9UNW9 (/NAS) Q9UNW9 (/NAS) Q9UNW9 (/NAS)
(1 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 A0A1W2P872 (/IDA) D3YVV7 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P51513 (/TAS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q9JKN6 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P51513 (/IPI)
Pre-mRNA intronic binding GO:0097157
Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA).
1 A0A0B4KGY6 (/IDA)
Showing 1 to 7 of 7 entries

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
16 A0A0G2JVE8 (/ISS) D4AAF8 (/ISS) F1M4H5 (/ISS) P51513 (/ISS) Q80WA4 (/ISS) Q9UNW9 (/ISS) Q9UNW9 (/ISS) Q9UNW9 (/ISS) Q9UNW9 (/ISS) Q9UNW9 (/ISS)
(6 more)
Regulation of RNA metabolic process GO:0051252
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
3 A0A1W2P872 (/IGI) D3YVV7 (/IGI) Q9JKN6 (/IGI)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
3 A0A1W2P872 (/IGI) D3YVV7 (/IGI) Q9JKN6 (/IGI)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 A0A0B4KGY6 (/HMP)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 A0A0B4KGY6 (/IMP)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
1 Q9JKN6 (/IDA)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
1 Q9JKN6 (/IMP)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
1 P51513 (/TAS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P51513 (/TAS)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 P51513 (/TAS)
Showing 1 to 10 of 15 entries

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
15 A0A0B4JCX5 (/IDA) A0A0B4KFY5 (/IDA) A0A0B4KGY6 (/IDA) A0A0B4LGY5 (/IDA) A0A0B4LI06 (/IDA) P51513 (/IDA) Q0KI94 (/IDA) Q0KI96 (/IDA) Q6AWM9 (/IDA) Q8IGS7 (/IDA)
(5 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 A0A0B4JCX5 (/HDA) A0A0B4KFY5 (/HDA) A0A0B4KGY6 (/HDA) A0A0B4LGY5 (/HDA) A0A0B4LI06 (/HDA) Q0KI94 (/HDA) Q0KI96 (/HDA) Q6AWM9 (/HDA) Q8IGS7 (/HDA) Q8INP0 (/HDA)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9JKN6 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9JKN6 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P51513 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9JKN6 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P51513 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q9JKN6 (/ISO)
Showing 1 to 8 of 8 entries
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