The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
K Homology domain, type 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Far upstream element-binding protein 1 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 Q91WJ8 (/IPI) Q96AE4 (/IPI) Q96AE4 (/IPI) Q96AE4 (/IPI) Q96AE4 (/IPI) Q96AE4 (/IPI) Q96AE4 (/IPI) Q96AE4 (/IPI) Q96AE4 (/IPI) Q96AE4 (/IPI)
(1 more)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
10 Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
10 Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
10 Q96AE4 (/HDA) Q96AE4 (/HDA) Q96AE4 (/HDA) Q96AE4 (/HDA) Q96AE4 (/HDA) Q96AE4 (/HDA) Q96AE4 (/HDA) Q96AE4 (/HDA) Q96AE4 (/HDA) Q96AE4 (/HDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q91WJ8 (/IDA)
Sequence-specific double-stranded DNA binding GO:1990837
Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
1 Q91WJ8 (/IDA)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
10 Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS) Q96AE4 (/TAS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
10 Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 A0A2R8RQC2 (/IGI) Q6P2A9 (/IGI)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q91WJ8 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q91WJ8 (/ISO)
Somatic stem cell division GO:0048103
The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.
1 Q91WJ8 (/IMP)
Developmental cell growth GO:0048588
The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.
1 Q91WJ8 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q32PX7 (/IEP)
Hematopoietic stem cell proliferation GO:0071425
The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.
1 Q91WJ8 (/IMP)
Positive regulation of Schwann cell migration GO:1900149
Any process that activates or increases the frequency, rate or extent of Schwann cell migration.
1 Q32PX7 (/IMP)
Positive regulation of Schwann cell migration GO:1900149
Any process that activates or increases the frequency, rate or extent of Schwann cell migration.
1 Q91WJ8 (/ISO)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
15 E9PEB5 (/IDA) E9PEB5 (/IDA) E9PEB5 (/IDA) E9PEB5 (/IDA) E9PEB5 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA)
(5 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 Q32PX7 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q91WJ8 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q91WJ8 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q91WJ8 (/EXP)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q91WJ8 (/IDA)
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