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CATH Superfamily 3.30.1370.10

K Homology domain, type 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
K Homology domain, type 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1far upstream element-binding protein 1 isoform X1Mex-3 RNA-binding family member DRNA-binding protein Nova-1 isoform 1vigilin isoform X1far upstream element-binding protein 2Tudor and KH domain containing, isoform CRA_avigilin isoform X1SC:2Putative splicing factor 1protein quaking isoform X2protein quaking isoform X1SC:3Polyribonucleotide nucleotidyltransferaseKRR1 small subunit processome componentKRR1 small subunit processome componentexosome complex component RRP40vigilin isoform X1KH domain proteinExosome complex component Rrp4Exosome complex component RRP40KH type 1 domain proteinSC:4poly(RC)-binding protein 2 isoform X1Fragile X mental retardation 1, isoform CRA_epoly(RC)-binding protein 2 isoform X1Mex-3 RNA-binding family member BFar upstream element-binding protein 1 isoform X1vigilin isoform X1RNA-binding protein Nova-1 isoform 1Branchpoint-bridging protein-like proteinHeterogeneous nuclear ribonucleoprotein K, likePolyribonucleotide nucleotidyltransferase 1, mitochondrialvigilin isoform X1SC:5far upstream element-binding protein 1 isoform X1KH domain-containing 4, pre-mRNA-splicing factorvigilin isoform X1Vigilin isoform X1SC:6KH domain-containing protein 3poly(RC)-binding protein 2 isoform X1Ribonuclease YRNA-binding protein PNO1far upstream element-binding protein 1 isoform X1Fragile X mental retardation syndrome-related protein 1RNA-binding protein Nova-1 isoform 1Heterogeneous nuclear ribonucleoprotein K, likeHeterogeneous nuclear ribonucleoprotein K, likeInsulin-like growth factor 2 mRNA-binding protein 3insulin-like growth factor 2 mRNA-binding protein 3 isoform X1ankyrin repeat and KH domain-containing protein 1 isoform X2KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoformX2ankyrin repeat domain-containing protein 17 isoform X1synaptic functional regulator FMR1 isoform X2synaptic functional regulator FMR1 isoform X2KH RNA binding domain containing, signal transduction associated 1KH domain proteinKH domain-containing protein At2g38610KH domain-containing proteinKH domain-containing 4, pre-mRNA-splicing factorHigh density lipoprotein binding proteinsplicing factor-like protein 1RNA-binding protein PNO1 isoform X2Putative kh domain-containing proteinKep1, isoform AFragile X mental retardation syndrome-related protein 1Fragile X mental retardation protein 1Tudor and KH domain containingHigh density lipoprotein binding proteinpoly(RC)-binding protein 4 isoform X1Far upstream element binding protein 3High density lipoprotein binding proteinA-kinase anchor protein 1, mitochondrialprotein bicaudal C homolog 1 isoform X1KH domain-containing proteinKH domain containing 4, pre-mRNA splicing factorHigh density lipoprotein binding proteinIGF-II mRNA-binding protein, isoform DZinc finger CCCH domain-containing protein 52Uncharacterized proteinKH domain containing 1 likeUncharacterized protein, isoform ATranscription or splicing factor-like proteinSmall subunit rRNA processing KH domain protein, putativeKRR1 small subunit processome componentvigilin isoform X2Uncharacterized protein, isoform Adevelopmental pluripotency-associated 5 protein-likeRNA binding proteinRNA binding proteinRNA-binding protein PNO1DEAD (Asp-Glu-Ala-Asp) box polypeptide 43KH domain-containing, RNA-binding, signal transduction-associated protein 1 isoform X3KH domain-containing, RNA-binding, signal transduction-associated protein 1 isoform X3Oocyte-expressed protein homologKH domain containing 3 like, subcortical maternal complex memberUncharacterized protein, isoform ABnaC09g50550D proteinKRR1 small subunit processome componentPutative exosome complex exonuclease Rrp40PRE-binding proteinKH domain-containing proteinExosome complex component RRP40, putativeKH domain-containing proteinSplicing factor-like protein 1 isoform APbp2pPbp2pPutative branch point binding proteinActivating signal cointegrator 1 complex subunit 1Cleavage and polyadenylation specificity factor subunit 4Pbp2pUncharacterized proteinProtein CBG12765Scp160pScp160pDEAD box polypeptide 43 (Predicted)Heterogeneous nuclear rnp K-like protein 2Uncharacterized protein, isoform AUncharacterized protein, isoform AScp160pP-element somatic inhibitor, isoform AScp160pRNA-binding KH domain-containing proteinPoly(rC) binding protein 4Heterogeneous nuclear rnp K-like protein 2Uncharacterized protein, isoform DMeiotic recombination 1 proteinScp160pKH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X5Scp160pScp160pProtein CBR-SFA-1RNA-binding KH domain-containing proteinHeterogeneous nuclear ribonucleoprotein K, isoform BPre-rRNA-processing protein PNO1YLL032C-like proteinExosome complex exonuclease RRP40RNA-binding protein, putativeUncharacterized protein, isoform AUncharacterized protein, isoform BRE73736pRNA-binding protein, putativeKRR1 small subunit processome componentKH type 1 domain proteinExosome complex exonuclease RRP40, putativeRNA-binding KH domain-containing proteinKRR1 small subunit processome componentAGAP004145-PAPartner of Nob1Drosophila dodeca-satellite protein 1KH domain-containing proteinHeterogeneous nuclear rnp K-like protein 2FUBP1 isoform 1Protein CBG01583Uncharacterized proteinDrosophila dodeca-satellite protein 1Protein CBG06045Vigilin 1KH domain containing protein, putativeRNA-binding KH domain-containing proteinRNA-binding KH domain-containing proteinRNA-binding proteinKH homology domain-containing protein 1CDrosophila dodeca-satellite protein 1Putative eukaryotic LigTBranchpoint-bridging protein, putativeRNA-binding protein rnc1KRR1 small subunit processome componentKH domain-containing, RNA-binding, signal transduction-associated protein 3Protein CBG07980Far upstream element (FUSE)-binding protein 3Vigilin 1Exosome complex component Rrp4Exosome non-catalytic core subunitProtein CBR-NUO-2Vigilin 1Exosomal 3'-5' exoribonuclease complex subunit, putativeUncharacterized proteinTudor and KH domain-containing protein homologZinc finger CCCH domain-containing protein 52Tudor and KH domain-containing protein homologUncharacterized proteinHydrolaseDDX53 isoform 1Uncharacterized proteinUncharacterized proteinTudor and KH domain-containing protein homologKH domain containing 4, pre-mRNA splicing factorYALI0C05324pKH homology domain-containing protein 4-likeKRR1 small subunit processome componentKH homology domain-containing protein 4-likeYALI0C05324pProtein CBG16603Putative UPF0469 proteinKH domain-containing, RNA-binding, signal transduction-associated protein 3Protein CBG10565KH domain-containing proteinHigh density lipoprotein-binding protein aPredicted proteinPredicted proteinLOC553525 proteinSynaptic functional regulator FMR1Uncharacterized proteinVigilin 1Protein CBR-NUO-2Vigilin 1Uncharacterized proteinVigilin 1Uncharacterized proteinUncharacterized proteinUncharacterized proteinKRR1 small subunit processome component homolog-like proteinKRR1 small subunit processome component homolog-like proteinPolyribonucleotide nucleotidyltransferase, putativeUncharacterized proteinPredicted proteinAGAP004351-PAUncharacterized proteinATP-dependent RNA helicase p62-like ProteinVigilin 1Uncharacterized proteinVigilin 1RNA-binding protein rnc1LD29992pUncharacterized proteinUncharacterized proteinKRR1 small subunit processome componentPredicted proteinUncharacterized proteinUncharacterized proteinFar upstream element-binding protein 2KRR1 small subunit processome componentKH domain containing proteinKH domain containing proteinUncharacterized proteinPredicted proteinU1 snRNP-associated protein usp108Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinHeterogeneous nuclear RibonucleoProtein (HnRNP) K homologUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinPredicted proteinLD38872pEG:EG0003.2 protein (Fbgn0014870;psi protein)Hdlbp protein
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FunFam 13: Mex-3 RNA-binding family member B

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC TermAnnotationsEvidence
RING-type E3 ubiquitin transferase. [EC: 2.3.2.27]
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
  • RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein.
  • Unlike EC 2.3.2.26 the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin.
  • Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase).
  • In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32).
  • Cf. EC 2.3.2.31.
 2 Q05A36 Q5U5Q3
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