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CATH Superfamily 3.30.1370.10

K Homology domain, type 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
K Homology domain, type 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1far upstream element-binding protein 1 isoform X1Mex-3 RNA-binding family member DRNA-binding protein Nova-1 isoform 1vigilin isoform X1far upstream element-binding protein 2Tudor and KH domain containing, isoform CRA_avigilin isoform X1SC:2Putative splicing factor 1protein quaking isoform X2protein quaking isoform X1SC:3Polyribonucleotide nucleotidyltransferaseKRR1 small subunit processome componentKRR1 small subunit processome componentexosome complex component RRP40vigilin isoform X1KH domain proteinExosome complex component Rrp4Exosome complex component RRP40KH type 1 domain proteinSC:4poly(RC)-binding protein 2 isoform X1Fragile X mental retardation 1, isoform CRA_epoly(RC)-binding protein 2 isoform X1Mex-3 RNA-binding family member BFar upstream element-binding protein 1 isoform X1vigilin isoform X1RNA-binding protein Nova-1 isoform 1Branchpoint-bridging protein-like proteinHeterogeneous nuclear ribonucleoprotein K, likePolyribonucleotide nucleotidyltransferase 1, mitochondrialvigilin isoform X1SC:5far upstream element-binding protein 1 isoform X1KH domain-containing 4, pre-mRNA-splicing factorvigilin isoform X1Vigilin isoform X1SC:6KH domain-containing protein 3poly(RC)-binding protein 2 isoform X1Ribonuclease YRNA-binding protein PNO1far upstream element-binding protein 1 isoform X1Fragile X mental retardation syndrome-related protein 1RNA-binding protein Nova-1 isoform 1Heterogeneous nuclear ribonucleoprotein K, likeHeterogeneous nuclear ribonucleoprotein K, likeInsulin-like growth factor 2 mRNA-binding protein 3insulin-like growth factor 2 mRNA-binding protein 3 isoform X1ankyrin repeat and KH domain-containing protein 1 isoform X2KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoformX2ankyrin repeat domain-containing protein 17 isoform X1synaptic functional regulator FMR1 isoform X2synaptic functional regulator FMR1 isoform X2KH RNA binding domain containing, signal transduction associated 1KH domain proteinKH domain-containing protein At2g38610KH domain-containing proteinKH domain-containing 4, pre-mRNA-splicing factorHigh density lipoprotein binding proteinsplicing factor-like protein 1RNA-binding protein PNO1 isoform X2Putative kh domain-containing proteinKep1, isoform AFragile X mental retardation syndrome-related protein 1Fragile X mental retardation protein 1Tudor and KH domain containingHigh density lipoprotein binding proteinpoly(RC)-binding protein 4 isoform X1Far upstream element binding protein 3High density lipoprotein binding proteinA-kinase anchor protein 1, mitochondrialprotein bicaudal C homolog 1 isoform X1KH domain-containing proteinKH domain containing 4, pre-mRNA splicing factorHigh density lipoprotein binding proteinIGF-II mRNA-binding protein, isoform DZinc finger CCCH domain-containing protein 52Uncharacterized proteinKH domain containing 1 likeUncharacterized protein, isoform ATranscription or splicing factor-like proteinSmall subunit rRNA processing KH domain protein, putativeKRR1 small subunit processome componentvigilin isoform X2Uncharacterized protein, isoform Adevelopmental pluripotency-associated 5 protein-likeRNA binding proteinRNA binding proteinRNA-binding protein PNO1DEAD (Asp-Glu-Ala-Asp) box polypeptide 43KH domain-containing, RNA-binding, signal transduction-associated protein 1 isoform X3KH domain-containing, RNA-binding, signal transduction-associated protein 1 isoform X3Oocyte-expressed protein homologKH domain containing 3 like, subcortical maternal complex memberUncharacterized protein, isoform ABnaC09g50550D proteinKRR1 small subunit processome componentPutative exosome complex exonuclease Rrp40PRE-binding proteinKH domain-containing proteinExosome complex component RRP40, putativeKH domain-containing proteinSplicing factor-like protein 1 isoform APbp2pPbp2pPutative branch point binding proteinActivating signal cointegrator 1 complex subunit 1Cleavage and polyadenylation specificity factor subunit 4Pbp2pUncharacterized proteinProtein CBG12765Scp160pScp160pDEAD box polypeptide 43 (Predicted)Heterogeneous nuclear rnp K-like protein 2Uncharacterized protein, isoform AUncharacterized protein, isoform AScp160pP-element somatic inhibitor, isoform AScp160pRNA-binding KH domain-containing proteinPoly(rC) binding protein 4Heterogeneous nuclear rnp K-like protein 2Uncharacterized protein, isoform DMeiotic recombination 1 proteinScp160pKH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X5Scp160pScp160pProtein CBR-SFA-1RNA-binding KH domain-containing proteinHeterogeneous nuclear ribonucleoprotein K, isoform BPre-rRNA-processing protein PNO1YLL032C-like proteinExosome complex exonuclease RRP40RNA-binding protein, putativeUncharacterized protein, isoform AUncharacterized protein, isoform BRE73736pRNA-binding protein, putativeKRR1 small subunit processome componentKH type 1 domain proteinExosome complex exonuclease RRP40, putativeRNA-binding KH domain-containing proteinKRR1 small subunit processome componentAGAP004145-PAPartner of Nob1Drosophila dodeca-satellite protein 1KH domain-containing proteinHeterogeneous nuclear rnp K-like protein 2FUBP1 isoform 1Protein CBG01583Uncharacterized proteinDrosophila dodeca-satellite protein 1Protein CBG06045Vigilin 1KH domain containing protein, putativeRNA-binding KH domain-containing proteinRNA-binding KH domain-containing proteinRNA-binding proteinKH homology domain-containing protein 1CDrosophila dodeca-satellite protein 1Putative eukaryotic LigTBranchpoint-bridging protein, putativeRNA-binding protein rnc1KRR1 small subunit processome componentKH domain-containing, RNA-binding, signal transduction-associated protein 3Protein CBG07980Far upstream element (FUSE)-binding protein 3Vigilin 1Exosome complex component Rrp4Exosome non-catalytic core subunitProtein CBR-NUO-2Vigilin 1Exosomal 3'-5' exoribonuclease complex subunit, putativeUncharacterized proteinTudor and KH domain-containing protein homologZinc finger CCCH domain-containing protein 52Tudor and KH domain-containing protein homologUncharacterized proteinHydrolaseDDX53 isoform 1Uncharacterized proteinUncharacterized proteinTudor and KH domain-containing protein homologKH domain containing 4, pre-mRNA splicing factorYALI0C05324pKH homology domain-containing protein 4-likeKRR1 small subunit processome componentKH homology domain-containing protein 4-likeYALI0C05324pProtein CBG16603Putative UPF0469 proteinKH domain-containing, RNA-binding, signal transduction-associated protein 3Protein CBG10565KH domain-containing proteinHigh density lipoprotein-binding protein aPredicted proteinPredicted proteinLOC553525 proteinSynaptic functional regulator FMR1Uncharacterized proteinVigilin 1Protein CBR-NUO-2Vigilin 1Uncharacterized proteinVigilin 1Uncharacterized proteinUncharacterized proteinUncharacterized proteinKRR1 small subunit processome component homolog-like proteinKRR1 small subunit processome component homolog-like proteinPolyribonucleotide nucleotidyltransferase, putativeUncharacterized proteinPredicted proteinAGAP004351-PAUncharacterized proteinATP-dependent RNA helicase p62-like ProteinVigilin 1Uncharacterized proteinVigilin 1RNA-binding protein rnc1LD29992pUncharacterized proteinUncharacterized proteinKRR1 small subunit processome componentPredicted proteinUncharacterized proteinUncharacterized proteinFar upstream element-binding protein 2KRR1 small subunit processome componentKH domain containing proteinKH domain containing proteinUncharacterized proteinPredicted proteinU1 snRNP-associated protein usp108Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinHeterogeneous nuclear RibonucleoProtein (HnRNP) K homologUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinPredicted proteinLD38872pEG:EG0003.2 protein (Fbgn0014870;psi protein)Hdlbp protein
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FunFam 107: Scp160p

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
G-protein alpha-subunit binding GO:0001965
Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
 2 P06105 (/IPI) P06105 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
 2 P06105 (/IDA) P06105 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
 2 P06105 (/HDA) P06105 (/HDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
 2 P06105 (/IDA) P06105 (/IDA)
Showing 1 to 4 of 4 entries

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Pheromone-dependent signal transduction involved in conjugation with cellular fusion GO:0000750
A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
 2 P06105 (/IGI) P06105 (/IGI)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
 2 P06105 (/IGI) P06105 (/IGI)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
 2 P06105 (/IMP) P06105 (/IMP)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
 2 P06105 (/IMP) P06105 (/IMP)
Intracellular mRNA localization GO:0008298
Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
 2 P06105 (/IPI) P06105 (/IPI)
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
 2 P06105 (/IMP) P06105 (/IMP)
Chemotropism GO:0043577
The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it.
 2 P06105 (/IMP) P06105 (/IMP)
Meiotic telomere clustering GO:0045141
The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis.
 2 P06105 (/IMP) P06105 (/IMP)
Showing 1 to 8 of 8 entries

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
 2 P06105 (/HDA) P06105 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 2 P06105 (/IDA) P06105 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
 2 P06105 (/IDA) P06105 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
 2 P06105 (/IDA) P06105 (/IDA)
Polysome GO:0005844
A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.
 2 P06105 (/IDA) P06105 (/IDA)
Nuclear outer membrane-endoplasmic reticulum membrane network GO:0042175
The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.
 2 P06105 (/IDA) P06105 (/IDA)
Showing 1 to 6 of 6 entries
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