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CATH Superfamily 3.30.1130.10

GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: 7,8-dihydroneopterin aldolase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dihydroneopterin aldolase. [EC: 4.1.2.25]
7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.
  • The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis.
  • The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyze the epimerisation of the 2' hydroxy-group (EC 5.1.99.8).
  • The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyzes EC 5.1.99.8 and EC 1.13.11.81.
  • The enzyme from the yeast Saccharomyces cerevisiae also catalyzes the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3 and EC 2.5.1.15.
 521 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67
(511 more...)
7,8-dihydroneopterin epimerase. [EC: 5.1.99.8]
7,8-dihydroneopterin = 7,8-dihydromonapterin.
  • The enzyme, which has been characterized in bacteria and plants, also has the activity of EC 4.1.2.25.
  • The enzyme from the bacterium Mycobacterium tuberculosis has an additional oxygenase function (EC 1.13.11.81).
 342 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67
(332 more...)
7,8-dihydroneopterin oxygenase. [EC: 1.13.11.81]
7,8-dihydroneopterin + O(2) = 7,8-dihydroxanthopterin + formate + glycolaldehyde.
  • The enzyme from the bacterium Mycobacterium tuberculosis is multifunctional and also catalyzes the epimerisation of the 2'-hydroxy group of 7,8-dihydroneopterin (EC 5.1.99.8) and the reaction of EC 4.1.2.25.
 182 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67 A0A045KE67
(172 more...)
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