The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Peptide methionine sulphoxide reductase MsrA
".
FunFam 6: Peptide methionine sulfoxide reductase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Peptide-methionine (S)-S-oxide reductase activity GO:0008113
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
|
7 | P40029 (/IDA) P40029 (/IDA) P40029 (/IDA) P40029 (/IDA) P40029 (/IDA) P40029 (/IDA) P40029 (/IDA) |
|
Peptide-methionine (S)-S-oxide reductase activity GO:0008113
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
|
7 | P40029 (/IMP) P40029 (/IMP) P40029 (/IMP) P40029 (/IMP) P40029 (/IMP) P40029 (/IMP) P40029 (/IMP) |
|
Peptide-methionine (S)-S-oxide reductase activity GO:0008113
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
|
1 | Q09859 (/ISO) |
|
L-methionine-(S)-S-oxide reductase activity GO:0036456
Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O.
|
1 | Q09859 (/IMP) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
9 | C8V8B9 (/IMP) P40029 (/IMP) P40029 (/IMP) P40029 (/IMP) P40029 (/IMP) P40029 (/IMP) P40029 (/IMP) P40029 (/IMP) Q09859 (/IMP) |
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
7 | P40029 (/IGI) P40029 (/IGI) P40029 (/IGI) P40029 (/IGI) P40029 (/IGI) P40029 (/IGI) P40029 (/IGI) |
|
Protein repair GO:0030091
The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.
|
1 | Q09859 (/ISM) |
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | C8V8B9 (/IEP) |
|
L-methionine salvage from methionine sulphoxide GO:1990355
The generation of L-methionine from methionine sulphoxide.
|
1 | Q09859 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | P40029 (/HDA) P40029 (/HDA) P40029 (/HDA) P40029 (/HDA) P40029 (/HDA) P40029 (/HDA) P40029 (/HDA) Q09859 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
7 | P40029 (/HDA) P40029 (/HDA) P40029 (/HDA) P40029 (/HDA) P40029 (/HDA) P40029 (/HDA) P40029 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
7 | P40029 (/IDA) P40029 (/IDA) P40029 (/IDA) P40029 (/IDA) P40029 (/IDA) P40029 (/IDA) P40029 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q09859 (/HDA) |