The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptide methionine sulphoxide reductase MsrA
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Peptide methionine sulfoxide reductase MsrA

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptide-methionine (S)-S-oxide reductase activity GO:0008113
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
10 P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA)
L-methionine:thioredoxin-disulfide S-oxidoreductase activity GO:0033744
Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
10 P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA) P9WJM5 (/IDA)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
10 P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP)
Response to nitrosative stress GO:0051409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
10 P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP) P9WJM5 (/IMP)
Evasion or tolerance by symbiont of host-produced nitric oxide GO:0052060
The process in which an organism avoids the effects of nitric oxide produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
10 P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS) P9WJM5 (/TAS)
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