The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Antioxidant, Horf6; Chain A, domain2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: 1-Cys peroxiredoxin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
21 A1Z893 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS)
(11 more)
Antioxidant activity GO:0016209
Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
15 Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS)
(5 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 O08709 (/IPI) O08709 (/IPI) O35244 (/IPI) P30041 (/IPI) P30041 (/IPI) P30041 (/IPI) P30041 (/IPI) P30041 (/IPI) P73348 (/IPI) P73348 (/IPI)
(1 more)
Thioredoxin peroxidase activity GO:0008379
Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
11 P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) Q5A5A0 (/IDA)
(1 more)
Thioredoxin peroxidase activity GO:0008379
Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
9 P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP)
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
7 A1Z892 (/IDA) Q7JX87 (/IDA) Q95SB0 (/IDA) Q9GPQ0 (/IDA) Q9GPQ1 (/IDA) Q9GPQ2 (/IDA) Q9VQI7 (/IDA)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
5 P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
5 P30041 (/IPI) P30041 (/IPI) P30041 (/IPI) P30041 (/IPI) P30041 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
5 P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA)
Calcium-independent phospholipase A2 activity GO:0047499
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+.
5 P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP)
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
4 A2SZW8 (/IMP) A2SZW8 (/IMP) O08709 (/IMP) O08709 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P73348 (/IPI) P73348 (/IPI) P73348 (/IPI)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
2 O08709 (/ISO) O08709 (/ISO)
Thioredoxin peroxidase activity GO:0008379
Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
2 O04005 (/ISS) O04005 (/ISS)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 O08709 (/ISO) O08709 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 O08709 (/ISO) O08709 (/ISO)
Calcium-independent phospholipase A2 activity GO:0047499
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+.
2 O08709 (/ISO) O08709 (/ISO)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
1 O35244 (/IDA)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
16 A1Z893 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS) Q8IAM2 (/ISS)
(6 more)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
9 P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
9 P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
9 P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
9 P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
8 A1Z892 (/IDA) O35244 (/IDA) Q7JX87 (/IDA) Q95SB0 (/IDA) Q9GPQ0 (/IDA) Q9GPQ1 (/IDA) Q9GPQ2 (/IDA) Q9VQI7 (/IDA)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
5 O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
5 P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
5 P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
5 P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS)
Glycerophospholipid catabolic process GO:0046475
The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
5 P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP)
Positive regulation of mRNA splicing, via spliceosome GO:0048026
Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.
5 P30041 (/IGI) P30041 (/IGI) P30041 (/IGI) P30041 (/IGI) P30041 (/IGI)
Cellular oxidant detoxification GO:0098869
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
5 P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
2 O08709 (/IMP) O08709 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 O08709 (/ISO) O08709 (/ISO)
Response to desiccation GO:0009269
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water.
2 O04005 (/TAS) O04005 (/TAS)
Maintenance of seed dormancy GO:0010231
Any process that maintains a seed in a dormant state.
2 O04005 (/TAS) O04005 (/TAS)
Bleb assembly GO:0032060
The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
2 O08709 (/IMP) O08709 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q5A5A0 (/IMP) Q5A5A0 (/IMP)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
2 O08709 (/ISO) O08709 (/ISO)
Glycerophospholipid catabolic process GO:0046475
The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
2 O08709 (/ISO) O08709 (/ISO)
Positive regulation of mRNA splicing, via spliceosome GO:0048026
Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.
2 O08709 (/ISO) O08709 (/ISO)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
2 A2SZW8 (/IEP) A2SZW8 (/IEP)
Cellular oxidant detoxification GO:0098869
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
2 O08709 (/ISO) O08709 (/ISO)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
1 A1Z893 (/IEP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
24 A1Z892 (/IDA) O08709 (/IDA) O08709 (/IDA) Q7JX87 (/IDA) Q8IAM2 (/IDA) Q8IAM2 (/IDA) Q8IAM2 (/IDA) Q8IAM2 (/IDA) Q8IAM2 (/IDA) Q8IAM2 (/IDA)
(14 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
12 O08709 (/HDA) O08709 (/HDA) P34227 (/HDA) P34227 (/HDA) P34227 (/HDA) P34227 (/HDA) P34227 (/HDA) P34227 (/HDA) P34227 (/HDA) P34227 (/HDA)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 A1Z893 (/ISS) O35244 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) Q2PFL9 (/ISS) Q5R7E0 (/ISS) Q9TSX9 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
9 P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) Q5A5A0 (/IDA) Q5A5A0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) Q5A5A0 (/IDA) Q5A5A0 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P30041 (/NAS) P30041 (/NAS) P30041 (/NAS) P30041 (/NAS) P30041 (/NAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
5 P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
5 P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) P30041 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 F1NBV0 (/IDA) F1NBV0 (/IDA) Q5ZJF4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O08709 (/ISO) O08709 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O08709 (/ISO) O08709 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 O08709 (/ISO) O08709 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 A1Z893 (/ISS)
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