The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Phosphatidylinositol 3-kinase catalytic subunit ty...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
1-phosphatidylinositol-3-kinase activity GO:0016303
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
9 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) Q9TXI7 (/IDA)
1-phosphatidylinositol-3-kinase activity GO:0016303
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
9 P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) Q6FSR7 (/IMP)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
8 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P22543 (/IPI) P22543 (/IPI) P22543 (/IPI) P22543 (/IPI) P22543 (/IPI) P22543 (/IPI) P22543 (/IPI) P22543 (/IPI)
1-phosphatidylinositol-3-kinase activity GO:0016303
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
1 Q4QAC9 (/ISO)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
8 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA)
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
8 P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP)
Autophagy of peroxisome GO:0030242
The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions.
8 P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP)
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
8 P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP)
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
8 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA)
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
8 P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP)
Regulation of protein localization by the Cvt pathway GO:2001159
Any process that modulates the frequency, rate or extent of protein localization by the Cvt pathway.
8 P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP) P22543 (/IMP)
Reproduction GO:0000003
The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
1 Q9TXI7 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q9TXI7 (/IMP)
Nuclear envelope organization GO:0006998
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
1 Q9TXI7 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q9TXI7 (/IGI)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 Q6FSR7 (/IMP)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
1 Q9TXI7 (/IMP)
Phosphatidylinositol-3-phosphate biosynthetic process GO:0036092
The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.
1 Q9TXI7 (/IMP)
Ecdysis, collagen and cuticulin-based cuticle GO:0042395
The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates.
1 Q9TXI7 (/IMP)
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
1 Q4QAC9 (/ISO)
Regulation of protein secretion GO:0050708
Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q9TXI7 (/IMP)
Regulation of endosome size GO:0051036
Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis.
1 Q9TXI7 (/IGI)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
1 Q6FSR7 (/IMP)
Positive regulation of triglyceride lipase activity GO:0061365
Any process that increases the activity of triglyceride lipase.
1 Q9TXI7 (/IMP)
Protein localization to vacuole GO:0072665
A process in which a protein is transported to, or maintained at, a location in a vacuole.
1 Q6FSR7 (/IMP)
Phagosome maturation involved in apoptotic cell clearance GO:0090386
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
1 Q9TXI7 (/IGI)
Phagosome maturation involved in apoptotic cell clearance GO:0090386
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
1 Q9TXI7 (/IMP)
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
1 Q9TXI7 (/IGI)
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
1 Q9TXI7 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
8 P22543 (/HDA) P22543 (/HDA) P22543 (/HDA) P22543 (/HDA) P22543 (/HDA) P22543 (/HDA) P22543 (/HDA) P22543 (/HDA)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
8 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA)
Phagophore assembly site GO:0000407
Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
8 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
8 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
8 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 P22543 (/HDA) P22543 (/HDA) P22543 (/HDA) P22543 (/HDA) P22543 (/HDA) P22543 (/HDA) P22543 (/HDA) P22543 (/HDA)
Phosphatidylinositol 3-kinase complex, class III, type I GO:0034271
A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.
8 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA)
Phosphatidylinositol 3-kinase complex, class III, type II GO:0034272
A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.
8 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA)
Nucleus-vacuole junction GO:0071561
An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p.
8 P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA) P22543 (/IDA)
Nuclear outer membrane GO:0005640
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
1 Q9TXI7 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9TXI7 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9TXI7 (/IDA)
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