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CATH Superfamily 3.20.200.10

MHCK/EF2 kinase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MHCK/EF2 kinase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Eukaryotic elongation factor 2 kinase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
[Elongation factor 2] kinase. [EC: 2.7.11.20]
ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate.
  • Requires calmodulin for activity.
  • Can also be phosphorylated by the catalytic subunit of EC 2.7.11.11.
  • Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca(2+).
 4 O00418 O01991 O08796 P70531
[Myosin heavy-chain] kinase. [EC: 2.7.11.7]
ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate.
  • The enzyme from Dictyostelium sp. (slime molds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin.
  • One threonine residue in each heavy chain acts as acceptor.
  • While the enzyme from some species is activated by actin, in other cases Ca(2+)/calmodulin are required for activity.
  • Formerly EC 2.7.1.129.
 4 P42527 P90648 Q54SF9 Q8MY12
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