The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Ferredoxin-dependent glutamate synthase, chloroplasticGlutamate synthase, large subunitSC:104-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X14-hydroxy-tetrahydrodipicolinate synthase 2, chloroplasticPutative 2-dehydro-3-deoxy-D-gluconate aldolase YagE4-hydroxy-tetrahydrodipicolinate synthaseDihydrodipicolinate synthase DapAL-2-keto-3-deoxyarabonate dehydrataseDihydrodipicolinate synthase/N-acetylneuraminate lyaseSC:12Dihydropyrimidine dehydrogenase [NADP(+)]Dihydroorotate dehydrogenase (quinone)Dihydroorotate dehydrogenase (quinone), mitochondrialDihydroorotate dehydrogenase (quinone)Dihydroorotate dehydrogenase A (fumarate)Dihydroorotate dehydrogenase (quinone)SC:13Glucan 1,4-alpha-glucosidase SusBAlpha-galactosidaseSC:14Pyridoxine biosynthesis protein PDX1SC:153-hydroxy-5-phosphonooxypentane-2,4-dione thiolaseSC:17Delta-aminolevulinic acid dehydratasegalactocerebrosidase precursorSC:19Class II fructose-bisphosphate aldolaseD-tagatose-1,6-bisphosphate aldolase subunit GatYFructose-bisphosphate aldolase FbaD-tagatose-1,6-bisphosphate aldolase subunit GatZTriosephosphate isomeraseTriosephosphate isomeraseTriosephosphate isomeraseSC:2Alpha-galactosidaseUridine monophosphate synthetaseDecarboxylase,orotidine phosphateOrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferaseAlpha-galactosidaseAlpha-galactosidaseSC:20Cytochrome b2, mitochondrial, putativeperoxisomal (S)-2-hydroxy-acid oxidase GLO1Isopentenyl-diphosphate delta-isomeraseSC:21Thiazole synthaseKHG/KDPG aldolaseRibulose-phosphate 3-epimeraseTryptophan biosynthesis protein TRP1Thiamine-phosphate synthaseThiamine biosynthetic bifunctional enzymeMultifunctional fusion proteinD-allulose-6-phosphate 3-epimeraseThiamine-phosphate synthaseRibulose-phosphate 3-epimeraseribulose-phosphate 3-epimerase isoform X2Triosephosphate isomeraseRibulose-phosphate 3-epimeraseThiazole tautomeraseIndole-3-glycerol phosphate synthaseSC:22Ferredoxin-dependent glutamate synthase, chloroplasticSC:23Imidazole glycerol phosphate synthase subunit HisFFatty acid synthase beta subunit dehydratasetRNA-dihydrouridine(20/20a) synthaseImidazole glycerol phosphate synthase hisHF1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastictRNA-dihydrouridine(16) synthaseSC:24NADPH-dependent 2,4-dienoyl-CoA reductaseSC:25Biotin synthaseEthanolamine ammonia-lyase heavy chainbifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic3-dehydroquinate dehydratase3-dehydroquinate dehydrataseProline 2-methylase for pyrrolysine biosynthesisSC:3Putative N-acetylmannosamine-6-phosphate 2-epimeraseNicotinate phosphoribosyltransferaseNicotinate-nucleotide pyrophosphorylase [carboxylating]Tryptophan synthase alpha chain, chloroplastic1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseSC:4Deoxyribose-phosphate aldolaseDeoxyribose-phosphate aldolaseDeoxyribose-phosphate aldolaseSC:52-isopropylmalate synthaseHomocitrate synthase, mitochondrialHydroxymethylglutaryl-CoA lyase, mitochondrial2-isopropylmalate synthaseHydroxymethylglutaryl-CoA lyase4-hydroxy-2-oxovalerate aldolaseHydroxymethylglutaryl-CoA lyase2-isopropylmalate synthaseSC:6Chromosome 19 SCAF14664, whole genome shotgun sequenceGMP reductaseGMP reductaseInosine-5'-monophosphate dehydrogenase 2SC:7Dual-specificity RNA methyltransferase RlmNProbable dual-specificity RNA methyltransferase RlmNPyruvate formate-lyase-activating enzymeLysine 2,3-aminomutase7-carboxy-7-deazaguanine synthaseSC:8Probable nitronate monooxygenaseNADH:quinone reductaseSC:9HyaluronidaseTransaldolaseGMP reductaseRibulose-phosphate 3-epimerasePhospho-2-dehydro-3-deoxyheptonate aldolase1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseOrotidine 5'-phosphate decarboxylaseTriosephosphate isomeraseGlutamate synthase [NADH], amyloplasticProbable transaldolaseTriosephosphate isomeraseFructose-bisphosphate aldolase3-keto-L-gulonate-6-phosphate decarboxylase UlaDLipoyl synthaseIndole-3-glycerol phosphate synthaseTriosephosphate isomeraseBiotin synthaseL-lactate dehydrogenaseNicotinate-nucleotide pyrophosphorylase, carboxylatingGlutamate synthase 1 [NADH]Pyruvate carboxylaseLipoyl synthase, mitochondrialTryptophan synthase alpha chainN-acetylneuraminate lyaseLipoyl synthaseFructose-bisphosphate aldolase class IPyridoxine 5'-phosphate synthaseDeoxyribose-phosphate aldolase4-hydroxy-tetrahydrodipicolinate synthase3-dehydroquinate dehydrataseDelta-aminolevulinic acid dehydratasetRNA-dihydrouridine synthase BFructose-bisphosphate aldolaseGlutamate synthase large subunithydroxyacid oxidase 2GTP 3',8-cyclase2-dehydro-3-deoxyphosphooctonate aldolaseN-ethylmaleimide reductase, FMN-linkedIMP dehydrogenase subunitGlutamate synthase large subunitThiamine-phosphate synthasetRNA-dihydrouridine(47) synthase [NAD(P)(+)]Fructose-bisphosphate aldolaseDihydroorotate dehydrogenase12-oxophytodienoate reductase 3Coproporphyrinogen-III oxidaseNicotinamide phosphoribosyltransferaseDihydrouridine synthase 1 like7-carboxy-7-deazaguanine synthaseIMP dehydrogenase, putativeAnaerobic ribonucleoside-triphosphate reductase-activating proteinTransaldolaseSulfofructosephosphate aldolaseAlpha-galactosidaseBifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutasetRNA-dihydrouridine synthasetRNA-dihydrouridine synthaseDelta-aminolevulinic acid dehydratasePutative N-methylproline demethylasePutative deoxyribose-phosphate aldolaseGlycerol uptake operon antiterminator regulatory proteinDeoxyribose-phosphate aldolaseIMP dehydrogenase family proteinGlutamate synthase, large subunitFructose-1,6-bisphosphate aldolaseNicotinate phosphoribosyltransferaseIsopentenyl-diphosphate delta-isomeraseLipoyl synthasemolybdenum cofactor biosynthesis protein 1Alpha-galactosidasePyruvate carboxylaseDihydropyrimidine dehydrogenase (NADP(+)), chloroplastic2-iminoacetate synthase ThiHHeme chaperone HemWLipoyl synthase, mitochondrialNicotinate phosphoribosyltransferasePhospho-2-dehydro-3-deoxyheptonate aldolaseProbable galactinol--sucrose galactosyltransferase 1Ribulose-phosphate 3-epimeraseTransaldolaseFMN dependent dehydrogenaseN-acetylneuraminate pyruvate lyase7,8-didemethyl-8-hydroxy-5-deazariboflavin synthasePentafunctional AROM polypeptideMultifunctional tryptophan biosynthesis proteinTagatose 1,6-diphosphate aldolase 2NADPH dehydrogenase 1Phospho-2-dehydro-3-deoxyheptonate aldolaseFructose-bisphosphate aldolaseEF-P beta-lysylation protein EpmBsialic acid synthasetRNA-dihydrouridine(47) synthase [NAD(P)(+)]Indole-3-glycerol phosphate synthase chloroplasticPhospho-2-dehydro-3-deoxyheptonate aldolasetRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1Nicotinate-nucleotide pyrophosphorylase [carboxylating]Pyridoxine 5'-phosphate synthaseTryptophan synthaseradical S-adenosyl methionine domain-containing protein 2Nicotinate phosphoribosyltransferaseGlutamate synthase domain proteinOrotidine 5'-phosphate decarboxylaseBiotin synthasetRNA-dihydrouridine synthase 4Probable galactinol--sucrose galactosyltransferase 2Dual-specificity RNA methyltransferase RlmNtRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-likeTransaldolase B23S rRNA methyltransferaseHeme chaperone HemWtRNA-dihydrouridine synthaseFatty acid synthase subunit betaFatty acid synthaseRibulose-phosphate 3-epimeraseNicotinate phosphoribosyltransferaseTransaldolase type2-dehydro-3-deoxy-6-phosphogalactonate aldolaseN-(5'-phosphoribosyl)anthranilate isomeraseAlpha-galactosidaseNicotinate phosphoribosyltransferaseEpimeraseGlycerol uptake operon antiterminator regulatory proteinStachyose synthaseThiamine phosphate pyrophosphorylaseLipoyl synthaseFructose-bisphosphate aldolaseMycofactocin radical SAM maturase MftCNitronate monooxygenaseTrans-o-hydroxybenzylidenepyruvate hydratase-aldolaseribulose-phosphate 3-epimerase isoform X2Multifunctional tryptophan biosynthesis proteinL-lactate oxidaseOxaloacetate decarboxylase alpha subunitS-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthaseAlpha-galactosidasePhosphoribosylanthranilate isomeraseAnaerobic sulfatase maturaseMycofactocin system heme/flavin oxidoreductase MftDPeroxisomal (S)-2-hydroxy-acid oxidase GLO4Fructose-bisphosphate aldolaseAnaerobic sulfatase maturase AslBFructose-bisphosphate aldolaseDeoxyribose-phosphate aldolase (putative)2-nitropropane dioxygenaseNitronate monooxygenaseIndole-3-glycerol phosphate synthase1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseDeoxyribose-phosphate aldolase3-dehydroquinate dehydrataseRibulose-phosphate 3-epimeraseThiamine phosphate synthasetRNA-dihydrouridine synthaseRaffinose synthase Sip1 protein3-keto-5-aminohexanoate cleavage enzymeThiamine-phosphate pyrophosphorylaseTransaldolaseNicotinate phosphoribosyltransferaseFMN-dependent dehydrogenase family proteintRNA-dihydrouridine(20) synthase [NAD(P)+]-likePutative dihydrouridine synthase family proteinPyridoxine biosynthetic enzyme pdx1Deoxyribose-phosphate aldolaseNAD(P)H-dependent glutamate synthase, putativeDUS1p Dihydrouridine synthaseOrotidine 5'-phosphate decarboxylaseDeoxyribose-phosphate aldolaseTryptophan synthase alpha chaintRNA-dihydrouridine synthaseLipoyl synthase, mitochondrialOrotidine 5'-phosphate decarboxylaseDihydroorotate reductase PyrEProbable transmembrane GTPase FZO-like, chloroplastictRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3Bifunctional UMP-synthetaseOrotidine 5'-phosphate decarboxylasePyridoxine 5'-phosphate synthaseLipoyl synthase, mitochondrialLipoyl synthase, apicoplastGTP 3',8-cyclaseGlycoside hydrolase family 27Nicotinate phosphoribosyltransferase2-dehydro-3-deoxyphosphooctonate aldolase 2Dihydroorotate dehydrogenase, mitochondrialUncharacterized proteinPhosphatidylinositol 4-kinase type 2 alphaDihydroorotate dehydrogenase (quinone)Quinate repressor proteinL-lactate dehydrogenase (Cytochrome)NADH:flavin oxidoreductasePutative FMN-dependent dehydrogenasePyridoxine 5'-phosphate synthaseLipoyl synthase4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconateGlycerol uptake operon antiterminator regulatory proteinPyruvate carboxylaseLipoyl synthaseGlycerol uptake operon antiterminator regulatory proteinTriosephosphate isomerasetRNA-dihydrouridine synthaseThiamine-phosphate synthasePhosphoribosylanthranilate isomeraseLactate oxidasetRNA-dihydrouridine synthasetRNA-dihydrouridine synthaseProbable dihydrodipicolinate synthetaseThiamine-phosphate synthaseIsopentenyl-diphosphate delta-isomerasePossible oxidoreductaseGTP 3',8-cyclaseAlpha-galactosidase2-isopropylmalate synthaseOxidoreductase, 2-nitropropane dioxygenase family, putative (AFU_orthologue AFUA_7G03850)2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolaseN-acetylneuraminate lyaseUnplaced genomic scaffold supercont2.7, whole genome shotgun sequenceUnplaced genomic scaffold supercont1.2, whole genome shotgun sequenceDeoxyribose-phosphate aldolaseN-(5'-phosphoribosyl)anthranilate isomeraseUnplaced genomic scaffold supercont1.57, whole genome shotgun sequenceDelta-aminolevulinic acid dehydrataseNADPH dehydrogenaseGTP 3',8-cyclase 22-nitropropane dioxygenase familyImidazole glycerol phosphate synthase hisHFGlutamate synthase, large subunitKetose-bisphosphate aldolase class-II family proteinTIM-barrel enzyme family proteinLipoyl synthase, mitochondrialProtein CBG12371Probable galactinol--sucrose galactosyltransferase 57-carboxy-7-deazaguanine synthaseDihydroorotate reductase PyrE, putativeUncharacterized protein, isoform EProbable RNA methyltransferase PA14_40730Dihydrodipicolinate synthetase family protein2-isopropylmalate synthaseIndole-3-glycerol phosphate synthaseQuinate pathway repressor protein QutRtRNA-dihydrouridine synthaseAlpha-galactosidaseFructose-bisphosphate aldolase ADihydrouridine synthase (Dus), putativeRadical SAM domain proteinPutative Dihydrodipicolinate synthaseAt4g21320p-like proteinTriosephosphate isomerase 2Triosephosphate isomeraseFructose-bisphosphate aldolaseDihydroorotate dehydrogenase (quinone)Phospho-2-dehydro-3-deoxyheptonate aldolaseGTP 3',8-cyclase 1CNX2FO synthaseTriosephosphate isomeraseNADPH dehydrogenaseDihydroorotate dehydrogenase family proteinIMP dehydrogenaseGlycoside hydrolase family 36tRNA-dihydrouridine synthasetRNA-dihydrouridine(47) synthase [NAD(P)(+)]Conserved proteinOrotidine 5'-phosphate decarboxylaseThiamine-phosphate synthaseGTP 3',8-cyclasePossible methyltransferase (Methylase)Putative glutamate synthase [NADPH], large subunitGlutamate synthase, large subunitIMPDH2 isoform 4Metallo cofactor biosynthesis proteintRNA-dihydrouridine(20) synthase [NAD(P)+]-likeAlpha-galactosidasePutative galactinol--sucrose galactosyltransferase 1Ribonucleotide reductase of class III (Anaerobic), activating proteinRibulose-phosphate 3-epimeraseEnoyl-(Acyl-carrier-protein) reductase IIRadical SAM domain proteinN-(5'-phosphoribosyl)anthranilate isomeraseN-(5'-phosphoribosyl)anthranilate isomerasePhosphoribosylanthranilate isomerase 1Oxygen-independent coproporphyrinogen III oxidaseNicotinate phosphoribosyltransferaseHyaluronidase2-isopropylmalate synthase, truncationPyruvate formate-lyase 3 activating enzymeN-(5'-phosphoribosyl)anthranilate isomeraseDihydroorotate dehydrogenase (quinone), mitochondrialPutative 2-keto-3-deoxy-L-galactonate aldolaseBiotin synthasePutative pyridoxine biosynthesis protein pdx-1Pyridoxal 5'-phosphate synthase subunit PdxSDihydroorotate reductase PyrEFructose-bisphosphate aldolase, class IIRadical SAM domain proteinThiazole synthaseRelated to tRNA dihydrouridine synthaseAlpha-1,6-galactosidaseUncharacterized proteinMultifunctional fusion proteinMultifunctional tryptophan biosynthesis proteinMutator MutT proteinNicotinate phosphoribosyltransferaseHistone acetyltransferase Elp3 homologPutative transmembrane GTPase FZO-like, chloroplasticNicotinate phosphoribosyltransferaseShikimate biosynthesis protein AroDESimilar to quinate pathway repressor protein QutRWGS project CABT00000000 data, contig 2.5Polyketide biosynthesis protein PksEProbable tRNA-dihydrouridine synthaseProbable oxidoreductasePutative 12-oxophytodienoate reductase-like protein 2ATriosephosphate isomerase cytosolicHomocitrate synthaseUncharacterized proteinDeoxyribose-phosphate aldolase (putative)Putative 12-oxophytodienoate reductase 10Glycolate oxidase, putativePyridoxal 5'-phosphate synthase subunit PdxS2-isopropylmalate synthaseFMN-dependent alpha-hydroxy acid dehydrogenaseRadical SAM domain proteintRNA-dihydrouridine(16/17) synthase (NAD(P)(+))D-arabino 3-hexulose 6-phosphate aldehyde lyaseAnaerobic ribonucleoside-triphosphate reductase activating protein4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolaseGlycerol uptake operon antiterminator regulatory proteinGlycerol uptake operon antiterminator-related proteinPutative DNA modification/repair radical SAM proteinUncharacterized proteinXenobiotic reductase BFMN-dependent 2-nitropropane dioxygenaseInosine-5'-monophosphate dehydrogenase 2Quinate repressortRNA-dihydrouridine synthaseAlpha-galactosidasePredicted proteinHydroxyacid oxidase 2 (long chain)Nicotinate phosphoribosyltransferaseHomocitrate synthasetRNA-dihydrouridine(20) synthase [NAD(P)+]-like2-isopropylmalate synthase 1 chloroplasticPredicted proteinAlpha-galactosidaseUncharacterized proteinTriosephosphate isomerasedTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyaseNADPH dehydrogenase, putativetRNA-dihydrouridine synthasetRNA-dihydrouridine synthase3-dehydroquinate dehydratase1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseHeme chaperone HemWN-(5'-phosphoribosyl)anthranilate isomeraseThiamine-phosphate synthaseN-(5'-phosphoribosyl)anthranilate isomerase3-dehydroquinate dehydrataseN-(5'-phosphoribosyl)anthranilate isomeraseDihydroorotate dehydrogenase (quinone)Coenzyme PQQ synthesis protein EUncharacterized proteinUncharacterized proteinUncharacterized proteinMagnesium-dependent deoxyribonuclease, TatD family, and radical SAM domain iron-sulfur oxidoreductaseMultifunctional fusion proteinPentafunctional AROM polypeptide, putativeMultifunctional fusion proteinHydroxymethylglutaryl-CoA lyase, mitochondrial, putativeCinnamate reductase2,4-dienoyl-coa reductase-like proteinN-acetylneuraminic acid condensing enzymeN,N'-diacetyllegionaminic acid synthaseFructose-bisphosphate aldolase 3 chloroplasticUncharacterized proteinPutative 2-isopropylmalate synthaseGlutamate synthase 1 [NADH] chloroplasticAlpha-galactosidasetRNA-dihydrouridine synthaseLipoyl synthase 2Predicted proteinHomocitrate synthaseFructose-bisphosphate aldolaseDihydroorotate dehydrogenase (quinone)Dihydroorotate oxidaseComponent II, glutamine amidotransferaseRadical SAM domain proteinIndole-3-glycerol-phosphate synthaseUncharacterized proteinUncharacterized proteinUncharacterized proteinBiotin synthaseDihydroorotate dehydrogenaseN-acetylneuraminate lyaseHydroxymethylglutaryl-CoA lyaseDihydroorotate dehydrogenaseDihydroorotate dehydrogenase 2Dihydroorotate dehydrogenase 2Triosephosphate isomerasePutative dihydropyrimidine dehydrogenase [NADP+]Tungsten-containing aldehyde ferredoxin oxidoreductase cofactor modifying proteinImidazole glycerol phosphate synthase subunit HisFtRNA-dihydrouridine(47) synthase [NAD(P)(+)]Dihydroorotate dehydrogenaseAlkaline alpha galactosidase 2PelAFructose-bisphosphate aldolase class 1tRNA-dihydrouridine synthase 2, putativePredicted proteinFe hydrogenase maturation rSAM protein HydGRadical S-adenosyl methionine domain-containing protein 1, mitochondrialPutative imidazole glycerol phosphate synthase subunit hisF2L-lactate dehydrogenaseGlutamate synthase, iron-sulfur cluster-binding subunit, putativeGlycolate oxidaseFructose-bisphosphate aldolaseUncharacterized proteinFerredoxin-dependent glutamate synthase GlsFDihydroorotate dehydrogenase (quinone)Isopentenyl-diphosphate delta-isomerase (Type II)2-nitropropane dioxygenaseBll6350 proteinUncharacterized proteinDelta-aminolevulinic acid dehydrataseGTP 3',8-cyclaseInosine-5'-monophosphate dehydrogenaseDelta-aminolevulinic acid dehydrataseInosine-5'-monophosphate dehydrogenaseDelta-aminolevulinic acid dehydrataseUncharacterized proteinPeroxisomal (S)-2-hydroxy-acid oxidase GLO1Tryptophan synthaseFerredoxin/NAD(P)H-dependent glutamate synthase, large subunitAcetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putativeAcyl carrier proteinPredicted proteintRNA-dihydrouridine synthaseGlycolate oxidaseUncharacterized proteinPutative NADPH dehydrogenase C23G7.10c
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FunFam 791:

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 0 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

There are 0 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
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