The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 78: Fatty acid synthase beta subunit dehydratase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 33 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty acid synthase activity GO:0004312
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
3 Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA)
[acyl-carrier-protein] S-acetyltransferase activity GO:0004313
Catalysis of the reaction: acetyl-CoA +
3 Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA)
[acyl-carrier-protein] S-malonyltransferase activity GO:0004314
Catalysis of the reaction: malonyl-CoA +
3 Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA)
3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0004315
Catalysis of the reaction: acyl-
3 Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA)
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity GO:0004316
Catalysis of the reaction: (3R)-3-hydroxyacyl-
3 Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA)
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity GO:0004317
Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-
3 Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA)
Enoyl-[acyl-carrier-protein] reductase (NADH) activity GO:0004318
Catalysis of the reaction: acyl-
3 Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA)
Oleoyl-[acyl-carrier-protein] hydrolase activity GO:0004320
Catalysis of the reaction: oleoyl-
3 Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA)
Fatty-acyl-CoA synthase activity GO:0004321
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
3 Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA)
GMP synthase activity GO:0003921
Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+).
2 Q5AQM2 (/RCA) Q5AQM2 (/RCA)
Acetyl-CoA carboxylase activity GO:0003989
Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
2 Q5AQM2 (/RCA) Q5AQM2 (/RCA)
Fatty acid synthase activity GO:0004312
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2 Q5AQM2 (/ISA) Q5AQM2 (/ISA)
[acyl-carrier-protein] S-acetyltransferase activity GO:0004313
Catalysis of the reaction: acetyl-CoA +
2 P07149 (/IDA) P07149 (/IDA)
[acyl-carrier-protein] S-acetyltransferase activity GO:0004313
Catalysis of the reaction: acetyl-CoA +
2 P07149 (/IMP) P07149 (/IMP)
[acyl-carrier-protein] S-malonyltransferase activity GO:0004314
Catalysis of the reaction: malonyl-CoA +
2 P07149 (/IDA) P07149 (/IDA)
[acyl-carrier-protein] S-malonyltransferase activity GO:0004314
Catalysis of the reaction: malonyl-CoA +
2 P07149 (/IMP) P07149 (/IMP)
Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity GO:0004319
Catalysis of the reaction: acyl-
2 P07149 (/IDA) P07149 (/IDA)
Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity GO:0004319
Catalysis of the reaction: acyl-
2 P07149 (/IMP) P07149 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P07149 (/IPI) P07149 (/IPI)
Palmitoyltransferase activity GO:0016409
Catalysis of the transfer of a palmitoyl (CH3-
2 P07149 (/IDA) P07149 (/IDA)
Palmitoyltransferase activity GO:0016409
Catalysis of the transfer of a palmitoyl (CH3-
2 P07149 (/IMP) P07149 (/IMP)
3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity GO:0019171
Catalysis of the reaction: a (3R)-3-hydroxyacyl-
2 P07149 (/IDA) P07149 (/IDA)
3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity GO:0019171
Catalysis of the reaction: a (3R)-3-hydroxyacyl-
2 P07149 (/IMP) P07149 (/IMP)
Fatty acid synthase activity GO:0004312
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
1 Q9UUG0 (/IDA)
[acyl-carrier-protein] S-acetyltransferase activity GO:0004313
Catalysis of the reaction: acetyl-CoA +
1 Q9UUG0 (/ISO)
[acyl-carrier-protein] S-acetyltransferase activity GO:0004313
Catalysis of the reaction: acetyl-CoA +
1 Q5A4W7 (/ISS)
[acyl-carrier-protein] S-malonyltransferase activity GO:0004314
Catalysis of the reaction: malonyl-CoA +
1 Q9UUG0 (/ISO)
[acyl-carrier-protein] S-malonyltransferase activity GO:0004314
Catalysis of the reaction: malonyl-CoA +
1 Q5A4W7 (/ISS)
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity GO:0004317
Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-
1 Q9UUG0 (/ISO)
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity GO:0004317
Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-
1 Q5A4W7 (/ISS)
Enoyl-[acyl-carrier-protein] reductase (NADH) activity GO:0004318
Catalysis of the reaction: acyl-
1 Q9UUG0 (/ISO)
Enoyl-[acyl-carrier-protein] reductase (NADH) activity GO:0004318
Catalysis of the reaction: acyl-
1 Q5A4W7 (/ISS)
Fatty-acyl-CoA synthase activity GO:0004321
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
1 Q9UUG0 (/NAS)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
3 Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
2 Q5AQM2 (/IMP) Q5AQM2 (/IMP)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
2 Q5AQM2 (/ISA) Q5AQM2 (/ISA)
Long-chain fatty acid biosynthetic process GO:0042759
The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22.
2 P07149 (/IMP) P07149 (/IMP)
Secondary metabolite biosynthetic process GO:0044550
The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
2 Q2UG02 (/IGC) Q2UG02 (/IGC)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q9UUG0 (/IDA)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q5A4W7 (/ISS)
Secondary metabolic process GO:0019748
The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.
1 Q00706 (/RCA)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q5A4W7 (/IMP)
Sterigmatocystin biosynthetic process GO:0045461
The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.
1 Q00706 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty acid synthase complex GO:0005835
A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA.
3 P07149 (/IDA) P07149 (/IDA) Q9UUG0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P07149 (/HDA) P07149 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P07149 (/HDA) P07149 (/HDA)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
2 P07149 (/IDA) P07149 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P07149 (/IDA) P07149 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9UUG0 (/HDA)
Fatty acid synthase complex GO:0005835
A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA.
1 Q5A4W7 (/ISS)
CATH-Gene3D is a Global Biodata Core Resource Learn more...