The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Aldolase class I
".
FunFam 45: 2-isopropylmalate synthase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
2-isopropylmalate synthase activity GO:0003852
Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
|
13 |
P06208 (/IDA)
P06208 (/IDA)
P06208 (/IDA)
P06208 (/IDA)
P06208 (/IDA)
P06208 (/IDA)
P9WQB3 (/IDA)
P9WQB3 (/IDA)
P9WQB3 (/IDA)
P9WQB3 (/IDA)
(3 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
P06208 (/IPI)
P06208 (/IPI)
P06208 (/IPI)
P06208 (/IPI)
P06208 (/IPI)
P06208 (/IPI)
P9WQB3 (/IPI)
P9WQB3 (/IPI)
P9WQB3 (/IPI)
P9WQB3 (/IPI)
(3 more) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
5 | P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
5 | P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) |
|
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
|
5 | P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) |
|
Potassium ion binding GO:0030955
Interacting selectively and non-covalently with potassium (K+) ions.
|
5 | P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) |
|
2-isopropylmalate synthase activity GO:0003852
Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
|
3 | O59736 (/ISS) Q12166 (/ISS) Q12166 (/ISS) |
|
2-isopropylmalate synthase activity GO:0003852
Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
|
2 | Q12166 (/IGI) Q12166 (/IGI) |
|
2-isopropylmalate synthase activity GO:0003852
Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
|
1 | C8VQ30 (/RCA) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
|
9 | O59736 (/IGI) P06208 (/IGI) P06208 (/IGI) P06208 (/IGI) P06208 (/IGI) P06208 (/IGI) P06208 (/IGI) Q12166 (/IGI) Q12166 (/IGI) |
|
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
|
9 | O59736 (/IMP) P06208 (/IMP) P06208 (/IMP) P06208 (/IMP) P06208 (/IMP) P06208 (/IMP) P06208 (/IMP) Q12166 (/IMP) Q12166 (/IMP) |
|
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
|
5 | P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) P9WQB3 (/IDA) |
|
Branched-chain amino acid metabolic process GO:0009081
The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
|
1 | C8VQ30 (/RCA) |
|
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | Q5AB86 (/IMP) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
9 | O59736 (/HDA) P06208 (/HDA) P06208 (/HDA) P06208 (/HDA) P06208 (/HDA) P06208 (/HDA) P06208 (/HDA) Q12166 (/HDA) Q12166 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
8 | P06208 (/IDA) P06208 (/IDA) P06208 (/IDA) P06208 (/IDA) P06208 (/IDA) P06208 (/IDA) Q12166 (/IDA) Q12166 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | P06208 (/HDA) P06208 (/HDA) P06208 (/HDA) P06208 (/HDA) P06208 (/HDA) P06208 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | P06208 (/IDA) P06208 (/IDA) P06208 (/IDA) P06208 (/IDA) P06208 (/IDA) P06208 (/IDA) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
5 | P9WQB3 (/HDA) P9WQB3 (/HDA) P9WQB3 (/HDA) P9WQB3 (/HDA) P9WQB3 (/HDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P9WQB3 (/HDA) P9WQB3 (/HDA) P9WQB3 (/HDA) P9WQB3 (/HDA) P9WQB3 (/HDA) |
