The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 37: Tryptophan synthase alpha chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lyase activity GO:0016829
Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
52 P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA)
(42 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 P00929 (/IPI) P00929 (/IPI) P00929 (/IPI) P00929 (/IPI) P00929 (/IPI) P00929 (/IPI) P00929 (/IPI) P00929 (/IPI) P00929 (/IPI) P00929 (/IPI)
(5 more)
Tryptophan synthase activity GO:0004834
Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O.
6 Q9KST7 (/ISS) Q9KST7 (/ISS) Q9KST7 (/ISS) Q9KST7 (/ISS) Q9KST7 (/ISS) Q9KST7 (/ISS)
Tryptophan synthase activity GO:0004834
Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O.
1 O13831 (/ISO)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tryptophan biosynthetic process GO:0000162
The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.
52 P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP)
(42 more)
Aromatic amino acid family biosynthetic process GO:0009073
The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
52 P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP) P0A877 (/IMP)
(42 more)
Tryptophan biosynthetic process GO:0000162
The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.
6 Q9KST7 (/ISS) Q9KST7 (/ISS) Q9KST7 (/ISS) Q9KST7 (/ISS) Q9KST7 (/ISS) Q9KST7 (/ISS)
Tryptophan biosynthetic process GO:0000162
The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.
2 P07344 (/IDA) P07344 (/IDA)
Tryptophan biosynthetic process GO:0000162
The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.
2 P07344 (/NAS) P07344 (/NAS)
Tryptophan biosynthetic process GO:0000162
The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.
1 O13831 (/ISO)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
52 P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA)
(42 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
52 P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA) P0A877 (/IDA)
(42 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 P9WFY1 (/HDA) P9WFY1 (/HDA) P9WFY1 (/HDA) P9WFY1 (/HDA) P9WFY1 (/HDA) P9WFY1 (/HDA) P9WFY1 (/HDA) P9WFY1 (/HDA) P9WFY1 (/HDA) P9WFY1 (/HDA)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O13831 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O13831 (/HDA)
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