The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 366: Hyaluronidase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hyalurononglucosaminidase activity GO:0004415
Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Hyaluronan synthase activity GO:0050501
Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine =
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Hyalurononglucosaminidase activity GO:0004415
Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
1 P86687 (/IDA)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Hyaluronan metabolic process GO:0030212
The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Hyaluronan biosynthetic process GO:0030213
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Hyaluronan catabolic process GO:0030214
The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Cellular response to platelet-derived growth factor stimulus GO:0036120
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Positive regulation of growth GO:0045927
Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Cellular response to pH GO:0071467
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Cellular response to UV-B GO:0071493
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Positive regulation of G1/S transition of mitotic cell cycle GO:1900087
Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Positive regulation of hyaluranon cable assembly GO:1900106
Any process that activates or increases the frequency, rate or extent of hyaluranon cable assembly.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Hyaluranon cable GO:0036117
A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan.
3 F1PSX9 (/ISS) F6SB02 (/ISS) F6SB02 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P86687 (/IDA) Q5D7H4 (/IDA)
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