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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 289: 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deo...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase. [EC: 4.1.2.55]
(1) 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate. (2) 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate.
  • In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway.
  • It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro- 3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency.
  • In vitro the enzyme can also catalyze the cleavage of the non- phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3- deoxy-D-galactonate with much lower catalytic efficiency.
  • Cf. EC 4.1.2.21 and EC 4.1.2.14.
 23 A0A0E3GT72 A0A0E3GT72 A0A0E3GT72 A0A0U3GTV7 A0A0U3GTV7 A0A0U3GTV7 A0A157T6F6 A0A157T6F6 D0KR10 D0KR10
(13 more...)
2-dehydro-3-deoxy-phosphogluconate aldolase. [EC: 4.1.2.14]
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
  • The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55).
  • Also acts on 2-oxobutanoate.
 1 Q704D1
2-dehydro-3-deoxy-D-gluconate aldolase. [EC: 4.1.2.51]
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde.
  • The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway.
  • In the direction of aldol synthesis the enzyme catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D- galactonate at a similar ratio.
  • It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate.
  • Cf. EC 4.1.2.14.
 1 Q704D1
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