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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: 3-keto-L-gulonate-6-phosphate decarboxylase UlaD

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-dehydro-L-gulonate-6-phosphate decarboxylase. [EC: 4.1.1.85]
3-dehydro-L-gulonate 6-phosphate = L-xylulose 5-phosphate + CO(2).
  • Along with EC 5.1.3.22, this enzyme is involved in a pathway for the utilization of L-ascorbate by Escherichia coli.
 21761 A0A026V3J5 A0A026V3J5 A0A026V3J5 A0A026V3J5 A0A026V3J5 A0A026V3J5 A0A026V3J5 A0A026V3J5 A0A026V3J5 A0A026V3J5
(21751 more...)
3-hexulose-6-phosphate synthase. [EC: 4.1.2.43]
D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde.
  • Specific for formaldehyde and D-ribulose 5-phosphate as substrates.
  • Ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate.
  • This enzyme, along with EC 5.3.1.27, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds.
  • The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyzes the reactions of this enzyme and EC 5.3.1.27.
 155 A0A090LRB6 A0A090LRB6 A0A090LRB6 A0A090LRB6 A0A090LRB6 A0A090LRB6 A0A090LRB6 A0A090LRB6 A0A090LRB6 A0A0B4N811
(145 more...)
5,6,7,8-tetrahydromethanopterin hydro-lyase. [EC: 4.2.1.147]
5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10- methylenetetrahydromethanopterin + H(2)O.
  • Found in methylotrophic bacteria and methanogenic archaea.
 12 A0A0E3RCW0 A0A0E3RCW0 A0A0E3RCW0 A0A0F8LR80 A0A0F8LR80 A0A0F8LR80 Q46DY5 Q58842 Q8PXE1 Q8PXE1
(2 more...)
Orotidine-5'-phosphate decarboxylase. [EC: 4.1.1.23]
Orotidine 5'-phosphate = UMP + CO(2).
  • The enzyme from higher eukaryotes is identical with EC 2.4.2.10.
 1 Q57700