The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Aldolase class I
".
FunFam 169: Fatty acid synthase subunit beta
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 33 GO terms relating to "molecular function"
			The search results have been sorted with the annotations that are found most frequently at the top of the
			list. The results can be filtered by typing text into the search box at the top of the table.
			
			
	| GO Term | Annotations | Evidence | 
|---|---|---|
| Fatty acid synthase activity GO:0004312 Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. | 3 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA) | 
| [acyl-carrier-protein] S-acetyltransferase activity GO:0004313 Catalysis of the reaction: acetyl-CoA + | 3 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA) | 
| [acyl-carrier-protein] S-malonyltransferase activity GO:0004314 Catalysis of the reaction: malonyl-CoA + | 3 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA) | 
| 3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0004315 Catalysis of the reaction: acyl- | 3 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA) | 
| 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity GO:0004316 Catalysis of the reaction: (3R)-3-hydroxyacyl- | 3 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA) | 
| 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity GO:0004317 Catalysis of the reaction: (3R)-3-hydroxypalmitoyl- | 3 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA) | 
| Enoyl-[acyl-carrier-protein] reductase (NADH) activity GO:0004318 Catalysis of the reaction: acyl- | 3 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA) | 
| Oleoyl-[acyl-carrier-protein] hydrolase activity GO:0004320 Catalysis of the reaction: oleoyl- | 3 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA) | 
| Fatty-acyl-CoA synthase activity GO:0004321 Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+. | 3 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA) | 
| GMP synthase activity GO:0003921 Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+). | 2 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) | 
| Acetyl-CoA carboxylase activity GO:0003989 Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. | 2 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) | 
| Fatty acid synthase activity GO:0004312 Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. | 2 | Q5AQM2 (/ISA) Q5AQM2 (/ISA) | 
| [acyl-carrier-protein] S-acetyltransferase activity GO:0004313 Catalysis of the reaction: acetyl-CoA + | 2 | P07149 (/IDA) P07149 (/IDA) | 
| [acyl-carrier-protein] S-acetyltransferase activity GO:0004313 Catalysis of the reaction: acetyl-CoA + | 2 | P07149 (/IMP) P07149 (/IMP) | 
| [acyl-carrier-protein] S-malonyltransferase activity GO:0004314 Catalysis of the reaction: malonyl-CoA + | 2 | P07149 (/IDA) P07149 (/IDA) | 
| [acyl-carrier-protein] S-malonyltransferase activity GO:0004314 Catalysis of the reaction: malonyl-CoA + | 2 | P07149 (/IMP) P07149 (/IMP) | 
| Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity GO:0004319 Catalysis of the reaction: acyl- | 2 | P07149 (/IDA) P07149 (/IDA) | 
| Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity GO:0004319 Catalysis of the reaction: acyl- | 2 | P07149 (/IMP) P07149 (/IMP) | 
| Protein binding GO:0005515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | 2 | P07149 (/IPI) P07149 (/IPI) | 
| Palmitoyltransferase activity GO:0016409 Catalysis of the transfer of a palmitoyl (CH3- | 2 | P07149 (/IDA) P07149 (/IDA) | 
| Palmitoyltransferase activity GO:0016409 Catalysis of the transfer of a palmitoyl (CH3- | 2 | P07149 (/IMP) P07149 (/IMP) | 
| 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity GO:0019171 Catalysis of the reaction: a (3R)-3-hydroxyacyl- | 2 | P07149 (/IDA) P07149 (/IDA) | 
| 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity GO:0019171 Catalysis of the reaction: a (3R)-3-hydroxyacyl- | 2 | P07149 (/IMP) P07149 (/IMP) | 
| Fatty acid synthase activity GO:0004312 Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. | 1 | Q9UUG0 (/IDA) | 
| [acyl-carrier-protein] S-acetyltransferase activity GO:0004313 Catalysis of the reaction: acetyl-CoA + | 1 | Q9UUG0 (/ISO) | 
| [acyl-carrier-protein] S-acetyltransferase activity GO:0004313 Catalysis of the reaction: acetyl-CoA + | 1 | Q5A4W7 (/ISS) | 
| [acyl-carrier-protein] S-malonyltransferase activity GO:0004314 Catalysis of the reaction: malonyl-CoA + | 1 | Q9UUG0 (/ISO) | 
| [acyl-carrier-protein] S-malonyltransferase activity GO:0004314 Catalysis of the reaction: malonyl-CoA + | 1 | Q5A4W7 (/ISS) | 
| 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity GO:0004317 Catalysis of the reaction: (3R)-3-hydroxypalmitoyl- | 1 | Q9UUG0 (/ISO) | 
| 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity GO:0004317 Catalysis of the reaction: (3R)-3-hydroxypalmitoyl- | 1 | Q5A4W7 (/ISS) | 
| Enoyl-[acyl-carrier-protein] reductase (NADH) activity GO:0004318 Catalysis of the reaction: acyl- | 1 | Q9UUG0 (/ISO) | 
| Enoyl-[acyl-carrier-protein] reductase (NADH) activity GO:0004318 Catalysis of the reaction: acyl- | 1 | Q5A4W7 (/ISS) | 
| Fatty-acyl-CoA synthase activity GO:0004321 Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+. | 1 | Q9UUG0 (/NAS) | 
There are 7 GO terms relating to "biological process"
			The search results have been sorted with the annotations that are found most frequently at the top of the
			list. The results can be filtered by typing text into the search box at the top of the table.
			
			
	| GO Term | Annotations | Evidence | 
|---|---|---|
| Fatty acid biosynthetic process GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. | 3 | Q5AQM2 (/RCA) Q5AQM2 (/RCA) Q5AV07 (/RCA) | 
| Fatty acid biosynthetic process GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. | 2 | Q5AQM2 (/IMP) Q5AQM2 (/IMP) | 
| Fatty acid biosynthetic process GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. | 2 | Q5AQM2 (/ISA) Q5AQM2 (/ISA) | 
| Long-chain fatty acid biosynthetic process GO:0042759 The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22. | 2 | P07149 (/IMP) P07149 (/IMP) | 
| Fatty acid biosynthetic process GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. | 1 | Q9UUG0 (/IDA) | 
| Fatty acid biosynthetic process GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. | 1 | Q5A4W7 (/ISS) | 
| Cellular response to drug GO:0035690 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. | 1 | Q5A4W7 (/IMP) | 
There are 7 GO terms relating to "cellular component"
			The search results have been sorted with the annotations that are found most frequently at the top of the
			list. The results can be filtered by typing text into the search box at the top of the table.
			
			
	| GO Term | Annotations | Evidence | 
|---|---|---|
| Fatty acid synthase complex GO:0005835 A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. | 3 | P07149 (/IDA) P07149 (/IDA) Q9UUG0 (/IDA) | 
| Cytoplasm GO:0005737 All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | 2 | P07149 (/HDA) P07149 (/HDA) | 
| Mitochondrion GO:0005739 A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | 2 | P07149 (/HDA) P07149 (/HDA) | 
| Lipid droplet GO:0005811 An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. | 2 | P07149 (/IDA) P07149 (/IDA) | 
| Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. | 2 | P07149 (/IDA) P07149 (/IDA) | 
| Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. | 1 | Q9UUG0 (/HDA) | 
| Fatty acid synthase complex GO:0005835 A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. | 1 | Q5A4W7 (/ISS) | 
