The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 152: radical S-adenosyl methionine domain-containing pr...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
6 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q8CBB9 (/ISS) Q9MZU4 (/ISS)
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
6 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q8CBB9 (/ISS) Q9MZU4 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q8CBB9 (/IPI) Q8WXG1 (/IPI)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 Q8WXG1 (/IDA)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 Q8CBB9 (/ISO)
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
1 Q8WXG1 (/IDA)
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
1 Q8CBB9 (/ISO)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of toll-like receptor 7 signaling pathway GO:0034157
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway.
6 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q8WXG1 (/ISS) Q9MZU4 (/ISS)
Positive regulation of toll-like receptor 9 signaling pathway GO:0034165
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway.
6 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q8WXG1 (/ISS) Q9MZU4 (/ISS)
CD4-positive, alpha-beta T cell activation GO:0035710
The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
6 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q8WXG1 (/ISS) Q9MZU4 (/ISS)
CD4-positive, alpha-beta T cell differentiation GO:0043367
The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
6 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q8WXG1 (/ISS) Q9MZU4 (/ISS)
Negative regulation of protein secretion GO:0050709
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
6 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q8CBB9 (/ISS) Q9MZU4 (/ISS)
Positive regulation of T-helper 2 cell cytokine production GO:2000553
Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.
6 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q8WXG1 (/ISS) Q9MZU4 (/ISS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
5 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q9MZU4 (/ISS)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
5 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q9MZU4 (/ISS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
3 Q5RH95 (/IDA) Q5RH95 (/IDA) Q8WXG1 (/IDA)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 Q8CBB9 (/IDA) Q8WXG1 (/IDA)
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 O70600 (/IDA)
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 Q8CBB9 (/ISO)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q8CBB9 (/IMP)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q8CBB9 (/ISO)
Regulation of ossification GO:0030278
Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 O70600 (/IDA)
Regulation of ossification GO:0030278
Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 Q8CBB9 (/ISO)
Positive regulation of toll-like receptor 7 signaling pathway GO:0034157
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway.
1 Q8CBB9 (/IMP)
Positive regulation of toll-like receptor 9 signaling pathway GO:0034165
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway.
1 Q8CBB9 (/IMP)
CD4-positive, alpha-beta T cell activation GO:0035710
The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
1 Q8CBB9 (/IMP)
CD4-positive, alpha-beta T cell differentiation GO:0043367
The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
1 Q8CBB9 (/IMP)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
1 Q8WXG1 (/IDA)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
1 Q8CBB9 (/IMP)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
1 Q8CBB9 (/ISO)
Negative regulation of protein secretion GO:0050709
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q8WXG1 (/IDA)
Negative regulation of protein secretion GO:0050709
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q8CBB9 (/ISO)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 Q8CBB9 (/ISO)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 Q8WXG1 (/TAS)
Positive regulation of T-helper 2 cell cytokine production GO:2000553
Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.
1 Q8CBB9 (/IMP)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
6 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q8CBB9 (/ISS) Q9MZU4 (/ISS)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
6 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q8WXG1 (/ISS) Q9MZU4 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
5 O70600 (/ISS) Q2HJF9 (/ISS) Q2HJF9 (/ISS) Q5RCW8 (/ISS) Q9MZU4 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 Q8CBB9 (/IDA) Q8WXG1 (/IDA)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
1 Q8WXG1 (/IDA)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
1 Q8CBB9 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8WXG1 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8CBB9 (/ISO)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 Q8WXG1 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 Q8CBB9 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q8WXG1 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q8CBB9 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q8CBB9 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q8WXG1 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q8CBB9 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q8WXG1 (/TAS)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
1 Q8CBB9 (/IDA)
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