The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Ferredoxin-dependent glutamate synthase, chloroplasticGlutamate synthase, large subunitSC:104-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X14-hydroxy-tetrahydrodipicolinate synthase 2, chloroplasticPutative 2-dehydro-3-deoxy-D-gluconate aldolase YagE4-hydroxy-tetrahydrodipicolinate synthaseDihydrodipicolinate synthase DapAL-2-keto-3-deoxyarabonate dehydrataseDihydrodipicolinate synthase/N-acetylneuraminate lyaseSC:12Dihydropyrimidine dehydrogenase [NADP(+)]Dihydroorotate dehydrogenase (quinone)Dihydroorotate dehydrogenase (quinone), mitochondrialDihydroorotate dehydrogenase (quinone)Dihydroorotate dehydrogenase A (fumarate)Dihydroorotate dehydrogenase (quinone)SC:13Glucan 1,4-alpha-glucosidase SusBAlpha-galactosidaseSC:14Pyridoxine biosynthesis protein PDX1SC:153-hydroxy-5-phosphonooxypentane-2,4-dione thiolaseSC:17Delta-aminolevulinic acid dehydratasegalactocerebrosidase precursorSC:19Class II fructose-bisphosphate aldolaseD-tagatose-1,6-bisphosphate aldolase subunit GatYFructose-bisphosphate aldolase FbaD-tagatose-1,6-bisphosphate aldolase subunit GatZTriosephosphate isomeraseTriosephosphate isomeraseTriosephosphate isomeraseSC:2Alpha-galactosidaseUridine monophosphate synthetaseDecarboxylase,orotidine phosphateOrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferaseAlpha-galactosidaseAlpha-galactosidaseSC:20Cytochrome b2, mitochondrial, putativeperoxisomal (S)-2-hydroxy-acid oxidase GLO1Isopentenyl-diphosphate delta-isomeraseSC:21Thiazole synthaseKHG/KDPG aldolaseRibulose-phosphate 3-epimeraseTryptophan biosynthesis protein TRP1Thiamine-phosphate synthaseThiamine biosynthetic bifunctional enzymeMultifunctional fusion proteinD-allulose-6-phosphate 3-epimeraseThiamine-phosphate synthaseRibulose-phosphate 3-epimeraseribulose-phosphate 3-epimerase isoform X2Triosephosphate isomeraseRibulose-phosphate 3-epimeraseThiazole tautomeraseIndole-3-glycerol phosphate synthaseSC:22Ferredoxin-dependent glutamate synthase, chloroplasticSC:23Imidazole glycerol phosphate synthase subunit HisFFatty acid synthase beta subunit dehydratasetRNA-dihydrouridine(20/20a) synthaseImidazole glycerol phosphate synthase hisHF1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastictRNA-dihydrouridine(16) synthaseSC:24NADPH-dependent 2,4-dienoyl-CoA reductaseSC:25Biotin synthaseEthanolamine ammonia-lyase heavy chainbifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic3-dehydroquinate dehydratase3-dehydroquinate dehydrataseProline 2-methylase for pyrrolysine biosynthesisSC:3Putative N-acetylmannosamine-6-phosphate 2-epimeraseNicotinate phosphoribosyltransferaseNicotinate-nucleotide pyrophosphorylase [carboxylating]Tryptophan synthase alpha chain, chloroplastic1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseSC:4Deoxyribose-phosphate aldolaseDeoxyribose-phosphate aldolaseDeoxyribose-phosphate aldolaseSC:52-isopropylmalate synthaseHomocitrate synthase, mitochondrialHydroxymethylglutaryl-CoA lyase, mitochondrial2-isopropylmalate synthaseHydroxymethylglutaryl-CoA lyase4-hydroxy-2-oxovalerate aldolaseHydroxymethylglutaryl-CoA lyase2-isopropylmalate synthaseSC:6Chromosome 19 SCAF14664, whole genome shotgun sequenceGMP reductaseGMP reductaseInosine-5'-monophosphate dehydrogenase 2SC:7Dual-specificity RNA methyltransferase RlmNProbable dual-specificity RNA methyltransferase RlmNPyruvate formate-lyase-activating enzymeLysine 2,3-aminomutase7-carboxy-7-deazaguanine synthaseSC:8Probable nitronate monooxygenaseNADH:quinone reductaseSC:9HyaluronidaseTransaldolaseGMP reductaseRibulose-phosphate 3-epimerasePhospho-2-dehydro-3-deoxyheptonate aldolase1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseOrotidine 5'-phosphate decarboxylaseTriosephosphate isomeraseGlutamate synthase [NADH], amyloplasticProbable transaldolaseTriosephosphate isomeraseFructose-bisphosphate aldolase3-keto-L-gulonate-6-phosphate decarboxylase UlaDLipoyl synthaseIndole-3-glycerol phosphate synthaseTriosephosphate isomeraseBiotin synthaseL-lactate dehydrogenaseNicotinate-nucleotide pyrophosphorylase, carboxylatingGlutamate synthase 1 [NADH]Pyruvate carboxylaseLipoyl synthase, mitochondrialTryptophan synthase alpha chainN-acetylneuraminate lyaseLipoyl synthaseFructose-bisphosphate aldolase class IPyridoxine 5'-phosphate synthaseDeoxyribose-phosphate aldolase4-hydroxy-tetrahydrodipicolinate synthase3-dehydroquinate dehydrataseDelta-aminolevulinic acid dehydratasetRNA-dihydrouridine synthase BFructose-bisphosphate aldolaseGlutamate synthase large subunithydroxyacid oxidase 2GTP 3',8-cyclase2-dehydro-3-deoxyphosphooctonate aldolaseN-ethylmaleimide reductase, FMN-linkedIMP dehydrogenase subunitGlutamate synthase large subunitThiamine-phosphate synthasetRNA-dihydrouridine(47) synthase [NAD(P)(+)]Fructose-bisphosphate aldolaseDihydroorotate dehydrogenase12-oxophytodienoate reductase 3Coproporphyrinogen-III oxidaseNicotinamide phosphoribosyltransferaseDihydrouridine synthase 1 like7-carboxy-7-deazaguanine synthaseIMP dehydrogenase, putativeAnaerobic ribonucleoside-triphosphate reductase-activating proteinTransaldolaseSulfofructosephosphate aldolaseAlpha-galactosidaseBifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutasetRNA-dihydrouridine synthasetRNA-dihydrouridine synthaseDelta-aminolevulinic acid dehydratasePutative N-methylproline demethylasePutative deoxyribose-phosphate aldolaseGlycerol uptake operon antiterminator regulatory proteinDeoxyribose-phosphate aldolaseIMP dehydrogenase family proteinGlutamate synthase, large subunitFructose-1,6-bisphosphate aldolaseNicotinate phosphoribosyltransferaseIsopentenyl-diphosphate delta-isomeraseLipoyl synthasemolybdenum cofactor biosynthesis protein 1Alpha-galactosidasePyruvate carboxylaseDihydropyrimidine dehydrogenase (NADP(+)), chloroplastic2-iminoacetate synthase ThiHHeme chaperone HemWLipoyl synthase, mitochondrialNicotinate phosphoribosyltransferasePhospho-2-dehydro-3-deoxyheptonate aldolaseProbable galactinol--sucrose galactosyltransferase 1Ribulose-phosphate 3-epimeraseTransaldolaseFMN dependent dehydrogenaseN-acetylneuraminate pyruvate lyase7,8-didemethyl-8-hydroxy-5-deazariboflavin synthasePentafunctional AROM polypeptideMultifunctional tryptophan biosynthesis proteinTagatose 1,6-diphosphate aldolase 2NADPH dehydrogenase 1Phospho-2-dehydro-3-deoxyheptonate aldolaseFructose-bisphosphate aldolaseEF-P beta-lysylation protein EpmBsialic acid synthasetRNA-dihydrouridine(47) synthase [NAD(P)(+)]Indole-3-glycerol phosphate synthase chloroplasticPhospho-2-dehydro-3-deoxyheptonate aldolasetRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1Nicotinate-nucleotide pyrophosphorylase [carboxylating]Pyridoxine 5'-phosphate synthaseTryptophan synthaseradical S-adenosyl methionine domain-containing protein 2Nicotinate phosphoribosyltransferaseGlutamate synthase domain proteinOrotidine 5'-phosphate decarboxylaseBiotin synthasetRNA-dihydrouridine synthase 4Probable galactinol--sucrose galactosyltransferase 2Dual-specificity RNA methyltransferase RlmNtRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-likeTransaldolase B23S rRNA methyltransferaseHeme chaperone HemWtRNA-dihydrouridine synthaseFatty acid synthase subunit betaFatty acid synthaseRibulose-phosphate 3-epimeraseNicotinate phosphoribosyltransferaseTransaldolase type2-dehydro-3-deoxy-6-phosphogalactonate aldolaseN-(5'-phosphoribosyl)anthranilate isomeraseAlpha-galactosidaseNicotinate phosphoribosyltransferaseEpimeraseGlycerol uptake operon antiterminator regulatory proteinStachyose synthaseThiamine phosphate pyrophosphorylaseLipoyl synthaseFructose-bisphosphate aldolaseMycofactocin radical SAM maturase MftCNitronate monooxygenaseTrans-o-hydroxybenzylidenepyruvate hydratase-aldolaseribulose-phosphate 3-epimerase isoform X2Multifunctional tryptophan biosynthesis proteinL-lactate oxidaseOxaloacetate decarboxylase alpha subunitS-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthaseAlpha-galactosidasePhosphoribosylanthranilate isomeraseAnaerobic sulfatase maturaseMycofactocin system heme/flavin oxidoreductase MftDPeroxisomal (S)-2-hydroxy-acid oxidase GLO4Fructose-bisphosphate aldolaseAnaerobic sulfatase maturase AslBFructose-bisphosphate aldolaseDeoxyribose-phosphate aldolase (putative)2-nitropropane dioxygenaseNitronate monooxygenaseIndole-3-glycerol phosphate synthase1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseDeoxyribose-phosphate aldolase3-dehydroquinate dehydrataseRibulose-phosphate 3-epimeraseThiamine phosphate synthasetRNA-dihydrouridine synthaseRaffinose synthase Sip1 protein3-keto-5-aminohexanoate cleavage enzymeThiamine-phosphate pyrophosphorylaseTransaldolaseNicotinate phosphoribosyltransferaseFMN-dependent dehydrogenase family proteintRNA-dihydrouridine(20) synthase [NAD(P)+]-likePutative dihydrouridine synthase family proteinPyridoxine biosynthetic enzyme pdx1Deoxyribose-phosphate aldolaseNAD(P)H-dependent glutamate synthase, putativeDUS1p Dihydrouridine synthaseOrotidine 5'-phosphate decarboxylaseDeoxyribose-phosphate aldolaseTryptophan synthase alpha chaintRNA-dihydrouridine synthaseLipoyl synthase, mitochondrialOrotidine 5'-phosphate decarboxylaseDihydroorotate reductase PyrEProbable transmembrane GTPase FZO-like, chloroplastictRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3Bifunctional UMP-synthetaseOrotidine 5'-phosphate decarboxylasePyridoxine 5'-phosphate synthaseLipoyl synthase, mitochondrialLipoyl synthase, apicoplastGTP 3',8-cyclaseGlycoside hydrolase family 27Nicotinate phosphoribosyltransferase2-dehydro-3-deoxyphosphooctonate aldolase 2Dihydroorotate dehydrogenase, mitochondrialUncharacterized proteinPhosphatidylinositol 4-kinase type 2 alphaDihydroorotate dehydrogenase (quinone)Quinate repressor proteinL-lactate dehydrogenase (Cytochrome)NADH:flavin oxidoreductasePutative FMN-dependent dehydrogenasePyridoxine 5'-phosphate synthaseLipoyl synthase4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconateGlycerol uptake operon antiterminator regulatory proteinPyruvate carboxylaseLipoyl synthaseGlycerol uptake operon antiterminator regulatory proteinTriosephosphate isomerasetRNA-dihydrouridine synthaseThiamine-phosphate synthasePhosphoribosylanthranilate isomeraseLactate oxidasetRNA-dihydrouridine synthasetRNA-dihydrouridine synthaseProbable dihydrodipicolinate synthetaseThiamine-phosphate synthaseIsopentenyl-diphosphate delta-isomerasePossible oxidoreductaseGTP 3',8-cyclaseAlpha-galactosidase2-isopropylmalate synthaseOxidoreductase, 2-nitropropane dioxygenase family, putative (AFU_orthologue AFUA_7G03850)2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolaseN-acetylneuraminate lyaseUnplaced genomic scaffold supercont2.7, whole genome shotgun sequenceUnplaced genomic scaffold supercont1.2, whole genome shotgun sequenceDeoxyribose-phosphate aldolaseN-(5'-phosphoribosyl)anthranilate isomeraseUnplaced genomic scaffold supercont1.57, whole genome shotgun sequenceDelta-aminolevulinic acid dehydrataseNADPH dehydrogenaseGTP 3',8-cyclase 22-nitropropane dioxygenase familyImidazole glycerol phosphate synthase hisHFGlutamate synthase, large subunitKetose-bisphosphate aldolase class-II family proteinTIM-barrel enzyme family proteinLipoyl synthase, mitochondrialProtein CBG12371Probable galactinol--sucrose galactosyltransferase 57-carboxy-7-deazaguanine synthaseDihydroorotate reductase PyrE, putativeUncharacterized protein, isoform EProbable RNA methyltransferase PA14_40730Dihydrodipicolinate synthetase family protein2-isopropylmalate synthaseIndole-3-glycerol phosphate synthaseQuinate pathway repressor protein QutRtRNA-dihydrouridine synthaseAlpha-galactosidaseFructose-bisphosphate aldolase ADihydrouridine synthase (Dus), putativeRadical SAM domain proteinPutative Dihydrodipicolinate synthaseAt4g21320p-like proteinTriosephosphate isomerase 2Triosephosphate isomeraseFructose-bisphosphate aldolaseDihydroorotate dehydrogenase (quinone)Phospho-2-dehydro-3-deoxyheptonate aldolaseGTP 3',8-cyclase 1CNX2FO synthaseTriosephosphate isomeraseNADPH dehydrogenaseDihydroorotate dehydrogenase family proteinIMP dehydrogenaseGlycoside hydrolase family 36tRNA-dihydrouridine synthasetRNA-dihydrouridine(47) synthase [NAD(P)(+)]Conserved proteinOrotidine 5'-phosphate decarboxylaseThiamine-phosphate synthaseGTP 3',8-cyclasePossible methyltransferase (Methylase)Putative glutamate synthase [NADPH], large subunitGlutamate synthase, large subunitIMPDH2 isoform 4Metallo cofactor biosynthesis proteintRNA-dihydrouridine(20) synthase [NAD(P)+]-likeAlpha-galactosidasePutative galactinol--sucrose galactosyltransferase 1Ribonucleotide reductase of class III (Anaerobic), activating proteinRibulose-phosphate 3-epimeraseEnoyl-(Acyl-carrier-protein) reductase IIRadical SAM domain proteinN-(5'-phosphoribosyl)anthranilate isomeraseN-(5'-phosphoribosyl)anthranilate isomerasePhosphoribosylanthranilate isomerase 1Oxygen-independent coproporphyrinogen III oxidaseNicotinate phosphoribosyltransferaseHyaluronidase2-isopropylmalate synthase, truncationPyruvate formate-lyase 3 activating enzymeN-(5'-phosphoribosyl)anthranilate isomeraseDihydroorotate dehydrogenase (quinone), mitochondrialPutative 2-keto-3-deoxy-L-galactonate aldolaseBiotin synthasePutative pyridoxine biosynthesis protein pdx-1Pyridoxal 5'-phosphate synthase subunit PdxSDihydroorotate reductase PyrEFructose-bisphosphate aldolase, class IIRadical SAM domain proteinThiazole synthaseRelated to tRNA dihydrouridine synthaseAlpha-1,6-galactosidaseUncharacterized proteinMultifunctional fusion proteinMultifunctional tryptophan biosynthesis proteinMutator MutT proteinNicotinate phosphoribosyltransferaseHistone acetyltransferase Elp3 homologPutative transmembrane GTPase FZO-like, chloroplasticNicotinate phosphoribosyltransferaseShikimate biosynthesis protein AroDESimilar to quinate pathway repressor protein QutRWGS project CABT00000000 data, contig 2.5Polyketide biosynthesis protein PksEProbable tRNA-dihydrouridine synthaseProbable oxidoreductasePutative 12-oxophytodienoate reductase-like protein 2ATriosephosphate isomerase cytosolicHomocitrate synthaseUncharacterized proteinDeoxyribose-phosphate aldolase (putative)Putative 12-oxophytodienoate reductase 10Glycolate oxidase, putativePyridoxal 5'-phosphate synthase subunit PdxS2-isopropylmalate synthaseFMN-dependent alpha-hydroxy acid dehydrogenaseRadical SAM domain proteintRNA-dihydrouridine(16/17) synthase (NAD(P)(+))D-arabino 3-hexulose 6-phosphate aldehyde lyaseAnaerobic ribonucleoside-triphosphate reductase activating protein4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolaseGlycerol uptake operon antiterminator regulatory proteinGlycerol uptake operon antiterminator-related proteinPutative DNA modification/repair radical SAM proteinUncharacterized proteinXenobiotic reductase BFMN-dependent 2-nitropropane dioxygenaseInosine-5'-monophosphate dehydrogenase 2Quinate repressortRNA-dihydrouridine synthaseAlpha-galactosidasePredicted proteinHydroxyacid oxidase 2 (long chain)Nicotinate phosphoribosyltransferaseHomocitrate synthasetRNA-dihydrouridine(20) synthase [NAD(P)+]-like2-isopropylmalate synthase 1 chloroplasticPredicted proteinAlpha-galactosidaseUncharacterized proteinTriosephosphate isomerasedTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyaseNADPH dehydrogenase, putativetRNA-dihydrouridine synthasetRNA-dihydrouridine synthase3-dehydroquinate dehydratase1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseHeme chaperone HemWN-(5'-phosphoribosyl)anthranilate isomeraseThiamine-phosphate synthaseN-(5'-phosphoribosyl)anthranilate isomerase3-dehydroquinate dehydrataseN-(5'-phosphoribosyl)anthranilate isomeraseDihydroorotate dehydrogenase (quinone)Coenzyme PQQ synthesis protein EUncharacterized proteinUncharacterized proteinUncharacterized proteinMagnesium-dependent deoxyribonuclease, TatD family, and radical SAM domain iron-sulfur oxidoreductaseMultifunctional fusion proteinPentafunctional AROM polypeptide, putativeMultifunctional fusion proteinHydroxymethylglutaryl-CoA lyase, mitochondrial, putativeCinnamate reductase2,4-dienoyl-coa reductase-like proteinN-acetylneuraminic acid condensing enzymeN,N'-diacetyllegionaminic acid synthaseFructose-bisphosphate aldolase 3 chloroplasticUncharacterized proteinPutative 2-isopropylmalate synthaseGlutamate synthase 1 [NADH] chloroplasticAlpha-galactosidasetRNA-dihydrouridine synthaseLipoyl synthase 2Predicted proteinHomocitrate synthaseFructose-bisphosphate aldolaseDihydroorotate dehydrogenase (quinone)Dihydroorotate oxidaseComponent II, glutamine amidotransferaseRadical SAM domain proteinIndole-3-glycerol-phosphate synthaseUncharacterized proteinUncharacterized proteinUncharacterized proteinBiotin synthaseDihydroorotate dehydrogenaseN-acetylneuraminate lyaseHydroxymethylglutaryl-CoA lyaseDihydroorotate dehydrogenaseDihydroorotate dehydrogenase 2Dihydroorotate dehydrogenase 2Triosephosphate isomerasePutative dihydropyrimidine dehydrogenase [NADP+]Tungsten-containing aldehyde ferredoxin oxidoreductase cofactor modifying proteinImidazole glycerol phosphate synthase subunit HisFtRNA-dihydrouridine(47) synthase [NAD(P)(+)]Dihydroorotate dehydrogenaseAlkaline alpha galactosidase 2PelAFructose-bisphosphate aldolase class 1tRNA-dihydrouridine synthase 2, putativePredicted proteinFe hydrogenase maturation rSAM protein HydGRadical S-adenosyl methionine domain-containing protein 1, mitochondrialPutative imidazole glycerol phosphate synthase subunit hisF2L-lactate dehydrogenaseGlutamate synthase, iron-sulfur cluster-binding subunit, putativeGlycolate oxidaseFructose-bisphosphate aldolaseUncharacterized proteinFerredoxin-dependent glutamate synthase GlsFDihydroorotate dehydrogenase (quinone)Isopentenyl-diphosphate delta-isomerase (Type II)2-nitropropane dioxygenaseBll6350 proteinUncharacterized proteinDelta-aminolevulinic acid dehydrataseGTP 3',8-cyclaseInosine-5'-monophosphate dehydrogenaseDelta-aminolevulinic acid dehydrataseInosine-5'-monophosphate dehydrogenaseDelta-aminolevulinic acid dehydrataseUncharacterized proteinPeroxisomal (S)-2-hydroxy-acid oxidase GLO1Tryptophan synthaseFerredoxin/NAD(P)H-dependent glutamate synthase, large subunitAcetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putativeAcyl carrier proteinPredicted proteintRNA-dihydrouridine synthaseGlycolate oxidaseUncharacterized proteinPutative NADPH dehydrogenase C23G7.10c
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FunFam 121: Dihydropyrimidine dehydrogenase (NADP(+)), chlorop...

GO Diversity

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Statistics

Members
CATH Domains: 0
Sequences: 88
Annotations
Unique GO: 6
Unique EC: 1
Unique Species: 71
Representative
Rep ID: Q9LVI9/52-368
Inherited Annotations: 0
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