The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphoenolpyruvate-binding domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Isocitrate lyase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Isocitrate lyase activity GO:0004451
Catalysis of the reaction: isocitrate = glyoxylate + succinate.
8 Q599M3 (/IDA) Q6T267 (/IDA) Q6T267 (/IDA) Q6T267 (/IDA) Q6T267 (/IDA) Q6Z6M4 (/IDA) Q6Z6M4 (/IDA) Q6Z6M4 (/IDA)
Isocitrate lyase activity GO:0004451
Catalysis of the reaction: isocitrate = glyoxylate + succinate.
7 P28240 (/IMP) P28240 (/IMP) P28240 (/IMP) P28240 (/IMP) P28240 (/IMP) P28240 (/IMP) P28240 (/IMP)
Isocitrate lyase activity GO:0004451
Catalysis of the reaction: isocitrate = glyoxylate + succinate.
3 P28297 (/TAS) P28297 (/TAS) P28297 (/TAS)
Methylisocitrate lyase activity GO:0046421
Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
3 Q12031 (/IDA) Q12031 (/IDA) Q599M3 (/IDA)
Isocitrate lyase activity GO:0004451
Catalysis of the reaction: isocitrate = glyoxylate + succinate.
2 P28298 (/RCA) Q599M3 (/RCA)
Isocitrate lyase activity GO:0004451
Catalysis of the reaction: isocitrate = glyoxylate + succinate.
1 P28298 (/ISO)
Methylisocitrate lyase activity GO:0046421
Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
1 Q599M3 (/IMP)
Methylisocitrate lyase activity GO:0046421
Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
1 Q9P6J1 (/ISS)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
9 P28240 (/IMP) P28240 (/IMP) P28240 (/IMP) P28240 (/IMP) P28240 (/IMP) P28240 (/IMP) P28240 (/IMP) Q59RB8 (/IMP) Q59RB8 (/IMP)
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
3 Q6Z6M4 (/NAS) Q6Z6M4 (/NAS) Q6Z6M4 (/NAS)
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
3 P28297 (/TAS) P28297 (/TAS) P28297 (/TAS)
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
2 P28298 (/RCA) Q599M3 (/RCA)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
2 Q59RB8 (/IMP) Q59RB8 (/IMP)
Propionate catabolic process, 2-methylcitrate cycle GO:0019629
The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.
2 Q12031 (/IDA) Q12031 (/IDA)
Threonine catabolic process GO:0006567
The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
1 Q9P6J1 (/ISS)
Fatty acid catabolic process GO:0009062
The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 P28298 (/IMP)
Carbon utilization GO:0015976
A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.
1 P28298 (/IMP)
Propionate catabolic process, 2-methylcitrate cycle GO:0019629
The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.
1 Q599M3 (/IMP)
Acetate catabolic process GO:0045733
The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid.
1 P28298 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P28240 (/IDA) P28240 (/IDA) P28240 (/IDA) P28240 (/IDA) P28240 (/IDA) P28240 (/IDA) P28240 (/IDA)
Glyoxysome GO:0009514
A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds.
6 P28297 (/IDA) P28297 (/IDA) P28297 (/IDA) Q6Z6M4 (/IDA) Q6Z6M4 (/IDA) Q6Z6M4 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
3 P28298 (/IDA) Q59RB8 (/IDA) Q59RB8 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q12031 (/HDA) Q12031 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q12031 (/IDA) Q12031 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q9P6J1 (/ISS)
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
1 P28298 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9P6J1 (/HDA)
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