View in Gene3D

CATH Superfamily 3.20.20.60

Phosphoenolpyruvate-binding domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphoenolpyruvate-binding domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 5: Isocitrate lyase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Isocitrate lyase. [EC: 4.1.3.1]
Isocitrate = succinate + glyoxylate.
  • The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3- tricarboxylate.
 10049 A0A026V3J0 A0A026V3J0 A0A026V3J0 A0A026V3J0 A0A026V3J0 A0A026V3J0 A0A026V3J0 A0A026V3J0 A0A026V3J0 A0A026V3J0
(10039 more...)
Methylisocitrate lyase. [EC: 4.1.3.30]
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
  • Acts on threo-D(s)-2-methylisocitrate, but not on threo-D(s)- isocitrate, threo-DL-isocitrate or erythro-L(s)-isocitrate.
 182 A0A045H6H0 A0A045H6H0 A0A045H6H0 A0A045H6H0 A0A045H6H0 A0A045H6H0 A0A045H6H0 A0A045H6H0 A0A045H6H0 A0A045H6H0
(172 more...)
Malate synthase. [EC: 2.3.3.9]
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
  • The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate.
  • Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2).
  • Formerly EC 4.1.3.2.
 1 Q10663
CATH-Gene3D is a Global Biodata Core Resource Learn more...