View in Gene3D

CATH Superfamily 3.20.20.450

EAL domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EAL domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 18: Probable diguanylate cyclase DgcE

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Diguanylate cyclase. [EC: 2.7.7.65]
2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate.
  • Can be activated by BeF3, a phosphoryl mimic, which results in dimerization.
  • Dimerization is required but is not sufficient for diguanylate- cyclase activity.
  • Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.
 16 A0A094XXS4 A0A094XXS4 A0A094XXS4 A0A094XXS4 E3PCL5 E3PCL5 E3PCL5 E3PCL5 L2UXN9 L2UXN9
(6 more...)
CATH-Gene3D is a Global Biodata Core Resource Learn more...