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CATH Superfamily 3.20.20.190

Phosphatidylinositol (PI) phosphodiesterase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol (PI) phosphodiesterase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 81: Glycosylphosphatidylinositol-specific phospholipas...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glycosylphosphatidylinositol diacylglycerol-lyase. [EC: 4.6.1.14]
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 6-(alpha-D- glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl- sn-glycerol.
  • This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure.
  • It therefore cleaves proteins from the lipid part of the glycosylphostphatidylinositol (GPI) anchors.
  • In some cases, the long-chain acyl group at the sn-1 position of glycerol is replaced by an alkyl or alk-1-enyl group.
  • In other cases, the diacylglycerol is replaced by ceramide.
  • The only characterized enzyme with this specificity is from Trypanosoma brucei, where the acyl groups are myristoyl, but the function of the trypanosome enzyme is unknown.
  • Substitution on O-2 of the inositol blocks action of this enzyme.
  • It is not identical with EC 3.1.4.50.
  • Formerly EC 3.1.4.47.
 1 P09194
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