The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Metal-dependent hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: AMP deaminase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
AMP deaminase activity GO:0003876
Catalysis of the reaction: AMP + H2O = IMP + NH3.
10 O08739 (/IDA) O09178 (/IDA) P15274 (/IDA) P15274 (/IDA) P15274 (/IDA) P15274 (/IDA) P15274 (/IDA) P15274 (/IDA) P50998 (/IDA) Q54DD0 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 O80452 (/IPI) O80452 (/IPI) P15274 (/IPI) P15274 (/IPI) P15274 (/IPI) P15274 (/IPI) P15274 (/IPI) P15274 (/IPI) Q01432 (/IPI)
AMP deaminase activity GO:0003876
Catalysis of the reaction: AMP + H2O = IMP + NH3.
7 O08739 (/IMP) P15274 (/IMP) P15274 (/IMP) P15274 (/IMP) P15274 (/IMP) P15274 (/IMP) P15274 (/IMP)
AMP deaminase activity GO:0003876
Catalysis of the reaction: AMP + H2O = IMP + NH3.
2 P23109 (/TAS) Q01432 (/TAS)
Protein histidine kinase binding GO:0043424
Interacting selectively and non-covalently with protein histidine kinase.
2 O80452 (/IPI) O80452 (/IPI)
AMP deaminase activity GO:0003876
Catalysis of the reaction: AMP + H2O = IMP + NH3.
1 O08739 (/ISO)
Myosin heavy chain binding GO:0032036
Interacting selectively and non-covalently with a heavy chain of a myosin complex.
1 P10759 (/IDA)
Myosin heavy chain binding GO:0032036
Interacting selectively and non-covalently with a heavy chain of a myosin complex.
1 Q3V1D3 (/ISO)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Purine nucleotide metabolic process GO:0006163
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
6 P15274 (/IGI) P15274 (/IGI) P15274 (/IGI) P15274 (/IGI) P15274 (/IGI) P15274 (/IGI)
Purine nucleotide metabolic process GO:0006163
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
6 P15274 (/IMP) P15274 (/IMP) P15274 (/IMP) P15274 (/IMP) P15274 (/IMP) P15274 (/IMP)
Guanine salvage GO:0006178
Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis.
6 P15274 (/IGI) P15274 (/IGI) P15274 (/IGI) P15274 (/IGI) P15274 (/IGI) P15274 (/IGI)
Guanine salvage GO:0006178
Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis.
6 P15274 (/IMP) P15274 (/IMP) P15274 (/IMP) P15274 (/IMP) P15274 (/IMP) P15274 (/IMP)
AMP catabolic process GO:0006196
The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate.
2 O09178 (/TAS) Q01432 (/TAS)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
2 O80452 (/IDA) O80452 (/IDA)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
2 O80452 (/IMP) O80452 (/IMP)
Purine-containing compound salvage GO:0043101
Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis.
2 P23109 (/TAS) Q01432 (/TAS)
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
1 Q54DD0 (/IMP)
IMP biosynthetic process GO:0006188
The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate.
1 O08739 (/IDA)
IMP biosynthetic process GO:0006188
The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate.
1 O08739 (/IMP)
Purine ribonucleoside monophosphate metabolic process GO:0009167
The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
1 Q54DD0 (/IDA)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P10759 (/IDA)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 Q3V1D3 (/ISO)
Sporulation resulting in formation of a cellular spore GO:0030435
The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.
1 Q54DD0 (/IMP)
IMP salvage GO:0032264
Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis.
1 Q54DD0 (/IDA)
Erythrocyte homeostasis GO:0034101
Any process of regulating the production and elimination of erythrocytes within an organism.
1 O08739 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 Q01432 (/TAS)
ADP metabolic process GO:0046031
The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate.
1 O08739 (/IMP)
AMP metabolic process GO:0046033
The chemical reactions and pathways involving AMP, adenosine monophosphate.
1 O08739 (/IMP)
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
1 O08739 (/IGI)
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
1 O08739 (/IMP)
GTP metabolic process GO:0046039
The chemical reactions and pathways involving GTP, guanosine triphosphate.
1 O08739 (/IGI)
GTP metabolic process GO:0046039
The chemical reactions and pathways involving GTP, guanosine triphosphate.
1 O08739 (/IMP)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
1 O08739 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P15274 (/HDA) P15274 (/HDA) P15274 (/HDA) P15274 (/HDA) P15274 (/HDA) P15274 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O80452 (/IDA) O80452 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O80452 (/IDA) O80452 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P23109 (/TAS) Q01432 (/TAS)
Integral component of mitochondrial outer membrane GO:0031307
The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 O80452 (/IDA) O80452 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 O80452 (/IDA) O80452 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q01432 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q54DD0 (/IC)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P50998 (/HDA)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
1 Q01432 (/TAS)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
1 Q01432 (/TAS)
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