The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Metal-dependent hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Adenosine deaminase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adenosine deaminase activity GO:0004000
Catalysis of the reaction: adenosine + H2O = inosine + NH3.
7 P58780 (/ISS) P58781 (/ISS) Q2VQV9 (/ISS) Q5RC46 (/ISS) Q8ST69 (/ISS) Q9VFS0 (/ISS) Q9VVK4 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
4 P58780 (/ISS) P58781 (/ISS) Q2VQV9 (/ISS) Q5RC46 (/ISS)
Adenosine receptor binding GO:0031685
Interacting selectively and non-covalently with an adenosine receptor.
4 P58780 (/ISS) P58781 (/ISS) Q2VQV9 (/ISS) Q5RC46 (/ISS)
Proteoglycan binding GO:0043394
Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
4 P58780 (/ISS) P58781 (/ISS) Q2VQV9 (/ISS) Q5RC46 (/ISS)
Adenosine deaminase activity GO:0004000
Catalysis of the reaction: adenosine + H2O = inosine + NH3.
3 Q9NZK5 (/IDA) Q9VFS1 (/IDA) Q9VVK5 (/IDA)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
1 Q9NZK5 (/NAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q9NZK5 (/IDA)
Adenosine receptor binding GO:0031685
Interacting selectively and non-covalently with an adenosine receptor.
1 Q9NZK5 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9NZK5 (/IPI)
Proteoglycan binding GO:0043394
Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
1 Q9NZK5 (/IDA)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adenosine catabolic process GO:0006154
The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.
7 P58780 (/ISS) P58781 (/ISS) Q2VQV9 (/ISS) Q5RC46 (/ISS) Q8ST69 (/ISS) Q9VFS0 (/ISS) Q9VVK4 (/ISS)
Adenosine catabolic process GO:0006154
The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.
3 Q9NZK5 (/IDA) Q9VFS1 (/IDA) Q9VVK5 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 Q9VFS1 (/IDA) Q9VVK5 (/IDA)
Neutrophil differentiation GO:0030223
The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.
2 A0A2R8QQB2 (/IMP) F6NKG5 (/IMP)
Blood vessel endothelial cell differentiation GO:0060837
The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels.
2 A0A2R8QQB2 (/IMP) F6NKG5 (/IMP)
Regulation of carbohydrate metabolic process GO:0006109
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.
1 Q9VVK5 (/IMP)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
1 Q9NZK5 (/NAS)
Larval lymph gland hemopoiesis GO:0035167
The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.
1 Q9VVK5 (/IGI)
Hemocyte differentiation GO:0042386
The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen.
1 Q9VVK5 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 Q9NZK5 (/TAS)
Cellular response to sucrose starvation GO:0043617
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose.
1 Q9VVK5 (/IMP)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
1 Q9NZK5 (/TAS)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 P58780 (/ISS) P58781 (/ISS) Q2VQV9 (/ISS) Q5RC46 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 Q9NZK5 (/IDA) Q9VFS1 (/IDA) Q9VVK5 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q9NZK5 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9VFS0 (/ISM)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
1 Q9NZK5 (/TAS)
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