The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Glycerol dehydrogenase Gcy1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Alditol:NADP+ 1-oxidoreductase activity GO:0004032
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
10 P14065 (/IDA) P14065 (/IDA) P14065 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA)
Carbonyl reductase (NADPH) activity GO:0004090
Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
7 Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
3 P14065 (/IDA) P14065 (/IDA) P14065 (/IDA)
Aldo-keto reductase (NADP) activity GO:0004033
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
3 P14065 (/IDA) P14065 (/IDA) P14065 (/IDA)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
3 P14065 (/IDA) P14065 (/IDA) P14065 (/IDA)
Glycerol dehydrogenase [NAD(P)+] activity GO:1990042
Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced.
3 P14065 (/IMP) P14065 (/IMP) P14065 (/IMP)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Arabinose catabolic process GO:0019568
The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose.
10 P14065 (/IDA) P14065 (/IDA) P14065 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
10 P14065 (/IGI) P14065 (/IGI) P14065 (/IGI) Q12458 (/IGI) Q12458 (/IGI) Q12458 (/IGI) Q12458 (/IGI) Q12458 (/IGI) Q12458 (/IGI) Q12458 (/IGI)
D-xylose catabolic process GO:0042843
The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide.
10 P14065 (/IDA) P14065 (/IDA) P14065 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA) Q12458 (/IDA)
Arabinose catabolic process GO:0019568
The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose.
7 Q12458 (/IMP) Q12458 (/IMP) Q12458 (/IMP) Q12458 (/IMP) Q12458 (/IMP) Q12458 (/IMP) Q12458 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q5ADT4 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 P14065 (/HDA) P14065 (/HDA) P14065 (/HDA) Q12458 (/HDA) Q12458 (/HDA) Q12458 (/HDA) Q12458 (/HDA) Q12458 (/HDA) Q12458 (/HDA) Q12458 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 P14065 (/HDA) P14065 (/HDA) P14065 (/HDA) Q12458 (/HDA) Q12458 (/HDA) Q12458 (/HDA) Q12458 (/HDA) Q12458 (/HDA) Q12458 (/HDA) Q12458 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 C8VSG5 (/IDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
1 Q5ADT4 (/IDA)
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