The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"NADP-dependent oxidoreductase domain
".
FunFam 167: Putative glutamate--cysteine ligase regulatory sub...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Glutamate-cysteine ligase catalytic subunit binding GO:0035226
Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase.
|
1 | O94246 (/ISO) |
|
Glutamate-cysteine ligase regulator activity GO:1990609
Binds to and modulates the activity of glutamate-cysteine ligase.
|
1 | O94246 (/ISO) |
There are 3 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Glutathione biosynthetic process GO:0006750
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
|
1 | O94246 (/ISO) |
|
Positive regulation of glutamate-cysteine ligase activity GO:0035229
Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.
|
1 | O94246 (/ISO) |
|
Cellular detoxification GO:1990748
Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
|
1 | O94246 (/NAS) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O94246 (/HDA) |
|
Glutamate-cysteine ligase complex GO:0017109
An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine.
|
1 | O94246 (/ISO) |
