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CATH Superfamily 3.20.20.100

NADP-dependent oxidoreductase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: 2,5-diketo-D-gluconic acid reductase B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aldo-keto reductase (NADP) activity GO:0004033
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
 38 P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA)
(28 more)
Aryl-alcohol dehydrogenase (NADP+) activity GO:0047681
Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH.
 38 P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA)
(28 more)
Methylglyoxal reductase (NADPH-dependent, acetol producing) GO:1990002
Catalysis of the reaction: H+ + methylglyoxal + NADPH <=> hydroxyacetone + NADP+.
 38 P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA) P30863 (/IDA)
(28 more)

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methylglyoxal catabolic process GO:0051596
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
 38 P30863 (/IMP) P30863 (/IMP) P30863 (/IMP) P30863 (/IMP) P30863 (/IMP) P30863 (/IMP) P30863 (/IMP) P30863 (/IMP) P30863 (/IMP) P30863 (/IMP)
(28 more)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.