The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"MutM-like, N-terminal
".
FunFam 2: Endonuclease 8
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
|
12 |
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
(2 more) |
|
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
|
12 |
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
(2 more) |
|
DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906
Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
|
12 |
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
(2 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
12 |
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
(2 more) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
11 |
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
(1 more) |
|
DNA N-glycosylase activity GO:0019104
Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
|
11 |
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
(1 more) |
There are 2 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Base-excision repair GO:0006284
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
|
12 |
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
P50465 (/IDA)
(2 more) |
|
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
11 |
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
P9WNC1 (/IDA)
(1 more) |
There are 0 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.