The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 41: FK506-binding nuclear protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P38911 (/IPI) P38911 (/IPI) P54397 (/IPI) Q06205 (/IPI) Q06205 (/IPI)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
4 P38911 (/IDA) P38911 (/IDA) Q06205 (/IDA) Q06205 (/IDA)
Macrolide binding GO:0005527
Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species.
4 P38911 (/IDA) P38911 (/IDA) Q06205 (/IDA) Q06205 (/IDA)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2 O74191 (/EXP) Q10175 (/EXP)
FK506 binding GO:0005528
Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506.
1 P54397 (/IDA)
Juvenile hormone response element binding GO:0070594
Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone.
1 P54397 (/IDA)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
4 P38911 (/IDA) P38911 (/IDA) Q06205 (/IDA) Q06205 (/IDA)
Histone peptidyl-prolyl isomerization GO:0000412
The modification of a histone by cis-trans isomerization of a proline residue.
2 Q06205 (/IDA) Q06205 (/IDA)
Histone peptidyl-prolyl isomerization GO:0000412
The modification of a histone by cis-trans isomerization of a proline residue.
2 O74191 (/ISM) Q10175 (/ISM)
Negative regulation of histone H3-K36 methylation GO:0000415
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
2 Q06205 (/IMP) Q06205 (/IMP)
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
2 O74191 (/ISO) Q10175 (/ISO)
Meiotic recombination checkpoint GO:0051598
A checkpoint that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes.
2 P38911 (/IDA) P38911 (/IDA)
Meiotic recombination checkpoint GO:0051598
A checkpoint that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes.
2 P38911 (/IMP) P38911 (/IMP)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 P54397 (/IMP)
Negative regulation of macroautophagy GO:0016242
Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
1 P54397 (/IMP)
Juvenile hormone mediated signaling pathway GO:0035626
A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity.
1 P54397 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
4 O74191 (/HDA) Q06205 (/HDA) Q06205 (/HDA) Q10175 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q06205 (/IDA) Q06205 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 P38911 (/IDA) P38911 (/IDA)
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
1 P54397 (/IDA)
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