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CATH Superfamily 3.10.490.10

Gamma-glutamyl cyclotransferase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Gamma-glutamyl cyclotransferase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Gamma-glutamylcyclotransferase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutathione-specific gamma-glutamylcyclotransferase. [EC: 4.3.2.7]
Glutathione = L-cysteinylglycine + 5-oxo-L-proline.
  • The enzyme, found in bacteria, fungi and animals, is specific for glutathione (cf. EC 4.3.2.9).
  • The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
 7 A4QNY6 A4QNY6 B3STU3 Q5SPB6 Q5SPB6 Q8R3J5 Q9BUX1
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