The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: arachidonate 12-lipoxygenase, 12R-type

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
2 O70582 (/IDA) O70582 (/IDA)
Arachidonate 12-lipoxygenase activity GO:0004052
Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
2 O70582 (/IDA) O70582 (/IDA)
Arachidonate 12-lipoxygenase activity GO:0004052
Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
2 O70582 (/ISO) O70582 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O75342 (/IPI) Q9BYJ1 (/IPI)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
2 O75342 (/IDA) Q9BYJ1 (/IDA)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
2 O70582 (/ISO) O70582 (/ISO)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
2 D3ZKX9 (/ISS) Q9WV07 (/ISS)
Arachidonate 15-lipoxygenase activity GO:0050473
Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.
2 O15296 (/IDA) Q8K4F2 (/IDA)
Hepoxilin A3 synthase activity GO:0051120
Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.
2 Q9BYJ1 (/IDA) Q9WV07 (/IDA)
Linoleate 9S-lipoxygenase activity GO:1990136
Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.
2 O70582 (/IDA) O70582 (/IDA)
Linoleate 9S-lipoxygenase activity GO:1990136
Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.
2 O75342 (/ISS) Q2KMM4 (/ISS)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
1 Q9WV07 (/ISA)
Arachidonate 12-lipoxygenase activity GO:0004052
Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
1 O75342 (/IMP)
Arachidonate 12-lipoxygenase activity GO:0004052
Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
1 Q2KMM4 (/ISS)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 O15296 (/IDA)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 O35936 (/ISO)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 Q8K4F2 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 O15296 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 O35936 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q8K4F2 (/ISS)
Linoleate 13S-lipoxygenase activity GO:0016165
Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate.
1 O15296 (/IDA)
Linoleate 13S-lipoxygenase activity GO:0016165
Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate.
1 O35936 (/ISO)
Arachidonate 8(S)-lipoxygenase activity GO:0036403
Catalysis of the reaction: arachidonate + O(2) = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate.
1 O35936 (/IDA)
Arachidonate 15-lipoxygenase activity GO:0050473
Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.
1 O35936 (/ISO)
Hepoxilin A3 synthase activity GO:0051120
Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.
1 Q9WV07 (/ISO)
Hepoxilin A3 synthase activity GO:0051120
Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.
1 D3ZKX9 (/ISS)
Hepoxilin A3 synthase activity GO:0051120
Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.
1 Q9BYJ1 (/TAS)

There are 66 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Arachidonic acid metabolic process GO:0019369
The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
9 D3ZKX9 (/IDA) O15296 (/IDA) O35936 (/IDA) O70582 (/IDA) O70582 (/IDA) Q2KMM4 (/IDA) Q8K4F2 (/IDA) Q9BYJ1 (/IDA) Q9WV07 (/IDA)
Sphingolipid metabolic process GO:0006665
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
5 D3ZKX9 (/ISS) O70582 (/ISS) O70582 (/ISS) Q2KMM4 (/ISS) Q9WV07 (/ISS)
Lipoxygenase pathway GO:0019372
The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.
5 D3ZKX9 (/ISS) O70582 (/ISS) O70582 (/ISS) Q2KMM4 (/ISS) Q9WV07 (/ISS)
Linoleic acid metabolic process GO:0043651
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
5 O35936 (/IDA) O70582 (/IDA) O70582 (/IDA) Q9BYJ1 (/IDA) Q9WV07 (/IDA)
Hepoxilin biosynthetic process GO:0051122
The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology.
5 D3ZKX9 (/IDA) Q2KMM4 (/IDA) Q8K4F2 (/IDA) Q9BYJ1 (/IDA) Q9WV07 (/IDA)
Arachidonic acid metabolic process GO:0019369
The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
4 O35936 (/ISO) O70582 (/ISO) O70582 (/ISO) Q9WV07 (/ISO)
Lipoxygenase pathway GO:0019372
The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.
4 O35936 (/IDA) O75342 (/IDA) Q8K4F2 (/IDA) Q9BYJ1 (/IDA)
Lipoxygenase pathway GO:0019372
The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.
4 O35936 (/ISO) O70582 (/ISO) O70582 (/ISO) Q9WV07 (/ISO)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
4 D3ZKX9 (/ISS) O75342 (/ISS) Q2KMM4 (/ISS) Q9BYJ1 (/ISS)
Hepoxilin biosynthetic process GO:0051122
The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology.
4 O35936 (/ISO) O70582 (/ISO) O70582 (/ISO) Q9WV07 (/ISO)
Hepoxilin biosynthetic process GO:0051122
The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology.
4 O15296 (/ISS) O70582 (/ISS) O70582 (/ISS) O75342 (/ISS)
Establishment of skin barrier GO:0061436
Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.
4 D3ZKX9 (/ISS) O75342 (/ISS) Q2KMM4 (/ISS) Q9BYJ1 (/ISS)
Sphingolipid metabolic process GO:0006665
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
3 O70582 (/ISO) O70582 (/ISO) Q9WV07 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 O70582 (/ISS) O70582 (/ISS) Q2KMM4 (/ISS)
Lipoxygenase pathway GO:0019372
The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.
3 O15296 (/TAS) O75342 (/TAS) Q9BYJ1 (/TAS)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
3 O70582 (/ISS) O70582 (/ISS) Q2KMM4 (/ISS)
Linoleic acid metabolic process GO:0043651
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
3 D3ZKX9 (/ISS) O75342 (/ISS) Q2KMM4 (/ISS)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
3 O70582 (/IMP) O70582 (/IMP) Q9WV07 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
3 O70582 (/ISS) O70582 (/ISS) Q2KMM4 (/ISS)
Establishment of skin barrier GO:0061436
Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.
3 O70582 (/IMP) O70582 (/IMP) Q9WV07 (/IMP)
Positive regulation of mucus secretion GO:0070257
Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.
3 O70582 (/ISS) O70582 (/ISS) Q2KMM4 (/ISS)
Protein lipidation GO:0006497
The covalent attachment of lipid groups to an amino acid in a protein.
2 O70582 (/IMP) O70582 (/IMP)
Protein lipidation GO:0006497
The covalent attachment of lipid groups to an amino acid in a protein.
2 O75342 (/ISS) Q2KMM4 (/ISS)
Sphingolipid metabolic process GO:0006665
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
2 O75342 (/IDA) Q9BYJ1 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 O70582 (/ISO) O70582 (/ISO)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
2 Q9BYJ1 (/ISS) Q9WV07 (/ISS)
Peroxisome proliferator activated receptor signaling pathway GO:0035357
The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes.
2 D3ZKX9 (/ISS) Q9BYJ1 (/ISS)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
2 O70582 (/ISO) O70582 (/ISO)
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
2 D3ZKX9 (/ISS) Q9BYJ1 (/ISS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
2 O70582 (/ISO) O70582 (/ISO)
Positive regulation of mucus secretion GO:0070257
Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.
2 O70582 (/ISO) O70582 (/ISO)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 O15296 (/TAS)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 O15296 (/TAS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 O15296 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 O15296 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 O35936 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9XT59 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O75342 (/IMP)
Positive regulation of macrophage derived foam cell differentiation GO:0010744
Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
1 O15296 (/IMP)
Positive regulation of macrophage derived foam cell differentiation GO:0010744
Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
1 O35936 (/ISO)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
1 D3ZKX9 (/IMP)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
1 Q9WV07 (/ISO)
Arachidonic acid metabolic process GO:0019369
The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
1 O75342 (/IMP)
Arachidonic acid metabolic process GO:0019369
The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
1 O75342 (/ISS)
Lipoxygenase pathway GO:0019372
The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.
1 O75342 (/IMP)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 O15296 (/TAS)
Prostate gland development GO:0030850
The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.
1 O15296 (/NAS)
Regulation of epithelial cell differentiation GO:0030856
Any process that modulates the frequency, rate or extent of epithelial cell differentiation.
1 O15296 (/NAS)
Peroxisome proliferator activated receptor signaling pathway GO:0035357
The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes.
1 Q9WV07 (/IMP)
Positive regulation of peroxisome proliferator activated receptor signaling pathway GO:0035360
Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.
1 O35936 (/IMP)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 O75342 (/IDA)
Linoleic acid metabolic process GO:0043651
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
1 Q9WV07 (/ISO)
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
1 Q9WV07 (/IMP)
Positive regulation of keratinocyte differentiation GO:0045618
Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.
1 O35936 (/IMP)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
1 O15296 (/IDA)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
1 O35936 (/ISO)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
1 Q9XT59 (/ISS)
Negative regulation of growth GO:0045926
Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
1 O15296 (/IDA)
Negative regulation of growth GO:0045926
Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
1 O35936 (/ISO)
Negative regulation of growth GO:0045926
Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
1 Q9XT59 (/ISS)
Hepoxilin biosynthetic process GO:0051122
The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology.
1 Q9WV07 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 O75342 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 O75342 (/IMP)
Positive regulation of mucus secretion GO:0070257
Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.
1 O75342 (/IMP)
Positive regulation of chemokine secretion GO:0090197
Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell.
1 O15296 (/IMP)
Positive regulation of chemokine secretion GO:0090197
Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell.
1 O35936 (/ISO)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O15296 (/TAS) O75342 (/TAS) Q9BYJ1 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 I3L1D5 (/IDA) O15296 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O35936 (/ISS) Q8K4F2 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 I3L1D5 (/IDA) O15296 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O35936 (/ISO)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
1 O15296 (/IDA)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
1 O35936 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O35936 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O15296 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O35936 (/ISO)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 O15296 (/IDA)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 O35936 (/ISO)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q8K4F2 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O15296 (/HDA)
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