The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 7: Nuclear transport factor 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
189 P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS)
(179 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
126 P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI)
(116 more)
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
126 P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI)
(116 more)
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
126 Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS)
(116 more)
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
63 P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA)
(53 more)
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
63 P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA)
(53 more)
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
63 P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI) P61970 (/IPI)
(53 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Nuclear import signal receptor activity GO:0061608
Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
63 P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA)
(53 more)
Nuclear import signal receptor activity GO:0061608
Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Nuclear import signal receptor activity GO:0061608
Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
63 P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS)
(53 more)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein localization to nuclear pore GO:0090204
A process in which a protein is transported to, or maintained in, a nuclear pore.
252 P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS)
(242 more)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
126 P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA)
(116 more)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
126 Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS) Q32KP9 (/ISS)
(116 more)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
63 P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP)
(53 more)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
63 P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA)
(53 more)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
63 P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP)
(53 more)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Protein localization to nuclear pore GO:0090204
A process in which a protein is transported to, or maintained in, a nuclear pore.
63 P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP)
(53 more)
Protein localization to nuclear pore GO:0090204
A process in which a protein is transported to, or maintained in, a nuclear pore.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Negative regulation of vascular endothelial growth factor production GO:1904046
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production.
63 P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP) P61972 (/IMP)
(53 more)
Negative regulation of vascular endothelial growth factor production GO:1904046
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
252 P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS)
(242 more)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
252 P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS) P61970 (/ISS)
(242 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
189 P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS) P61971 (/ISS)
(179 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
126 P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA)
(116 more)
Nuclear outer membrane GO:0005640
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
63 P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA)
(53 more)
Nuclear outer membrane GO:0005640
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
63 P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA) P61970 (/IDA)
(53 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
63 P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA)
(53 more)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Nuclear pore central transport channel GO:0044613
The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.
63 P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA) P61972 (/IDA)
(53 more)
Nuclear pore central transport channel GO:0044613
The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.
63 P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO) P61971 (/ISO)
(53 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
63 P61970 (/HDA) P61970 (/HDA) P61970 (/HDA) P61970 (/HDA) P61970 (/HDA) P61970 (/HDA) P61970 (/HDA) P61970 (/HDA) P61970 (/HDA) P61970 (/HDA)
(53 more)
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