The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Ras GTPase-activating protein-binding protein 2 is...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
18 P97855 (/IPI) Q13283 (/IPI) Q13283 (/IPI) Q13283 (/IPI) Q13283 (/IPI) Q9UN86 (/IPI) Q9UN86 (/IPI) Q9UN86 (/IPI) Q9UN86 (/IPI) Q9UN86 (/IPI)
(8 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
17 Q13283 (/HDA) Q13283 (/HDA) Q13283 (/HDA) Q13283 (/HDA) Q9UN86 (/HDA) Q9UN86 (/HDA) Q9UN86 (/HDA) Q9UN86 (/HDA) Q9UN86 (/HDA) Q9UN86 (/HDA)
(7 more)
Receptor signaling complex adaptor activity GO:0030159
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
13 Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS)
(3 more)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
4 Q13283 (/TAS) Q13283 (/TAS) Q13283 (/TAS) Q13283 (/TAS)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
4 Q13283 (/TAS) Q13283 (/TAS) Q13283 (/TAS) Q13283 (/TAS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 P97855 (/IDA)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of stress granule assembly GO:0062029
Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
17 Q13283 (/IMP) Q13283 (/IMP) Q13283 (/IMP) Q13283 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP)
(7 more)
Cytoplasmic sequestering of NF-kappaB GO:0007253
The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
13 Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS)
(3 more)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
13 Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS)
(3 more)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
13 Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP)
(3 more)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
4 Q13283 (/TAS) Q13283 (/TAS) Q13283 (/TAS) Q13283 (/TAS)
Type I interferon production GO:0032606
The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
4 Q13283 (/IDA) Q13283 (/IDA) Q13283 (/IDA) Q13283 (/IDA)
Type I interferon production GO:0032606
The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
4 Q13283 (/IMP) Q13283 (/IMP) Q13283 (/IMP) Q13283 (/IMP)
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
4 Q13283 (/IMP) Q13283 (/IMP) Q13283 (/IMP) Q13283 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
4 Q13283 (/IMP) Q13283 (/IMP) Q13283 (/IMP) Q13283 (/IMP)
Positive regulation of stress granule assembly GO:0062029
Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
3 P97379 (/ISO) P97379 (/ISO) P97855 (/ISO)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
2 P97379 (/ISO) P97379 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 P97379 (/ISO) P97379 (/ISO)
Type I interferon production GO:0032606
The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P97855 (/ISO)
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
1 P97855 (/ISO)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 P97855 (/ISO)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 P97855 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
45 A0A024RDB2 (/IDA) A0A024RDB2 (/IDA) A0A024RDB2 (/IDA) A0A024RDB2 (/IDA) A0A024RDB2 (/IDA) A0A024RDB2 (/IDA) A0A024RDB2 (/IDA) A0A024RDB2 (/IDA) A0A024RDB2 (/IDA) A0A024RDB2 (/IDA)
(35 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS) Q9UN86 (/NAS)
(3 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
13 Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP) Q9UN86 (/IMP)
(3 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
5 P97855 (/IDA) Q13283 (/IDA) Q13283 (/IDA) Q13283 (/IDA) Q13283 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q13283 (/TAS) Q13283 (/TAS) Q13283 (/TAS) Q13283 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q13283 (/IDA) Q13283 (/IDA) Q13283 (/IDA) Q13283 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
4 Q13283 (/HDA) Q13283 (/HDA) Q13283 (/HDA) Q13283 (/HDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
4 Q13283 (/ISS) Q13283 (/ISS) Q13283 (/ISS) Q13283 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P97379 (/ISO) P97379 (/ISO) P97855 (/ISO)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
3 P97379 (/ISO) P97379 (/ISO) P97855 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P97855 (/ISO)
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